Skeleton & clinical endpoints
About
At the Bonferroni significance level (P < 3.39e-5, multiple testing adjustment for both directions) , MR suggested 29 significant genetic causal effects (17 skeleton to clinical endpoints and 12 clinical outcomes to skeleton).
Overview of Skeleton MR results
(A) Skeleton -> Clinical endpoints (B) Clinical endpoints -> Skeleton
Skeleton MR results
| id.exposure | id.outcome | out.category | method | nsnp | b | se | pval | MR-Egger intercept pvalue | snps |
|---|---|---|---|---|---|---|---|---|---|
| Average_Forearm | Glaucoma | VII Diseases of the eye and adnexa (H7_) | MR Egger | 21 | 28.09 | 134.18 | 8.36E-01 | 0.55 | rs11022507,rs11965043,rs12685003,rs13726,rs149299821,rs1769758,rs1966265,rs2306937,rs2395617,rs2627692,rs35675358,rs3817428,rs4622705,rs4800452,rs4842841,rs4886782,rs56363908,rs6546231,rs6949451,rs800703,rs985036 |
| Average_Forearm | Glaucoma | VII Diseases of the eye and adnexa (H7_) | Inverse variance weighted (fixed effects) | 21 | -50.46 | 10.63 | 2.07E-06 | 0.55 | rs11022507,rs11965043,rs12685003,rs13726,rs149299821,rs1769758,rs1966265,rs2306937,rs2395617,rs2627692,rs35675358,rs3817428,rs4622705,rs4800452,rs4842841,rs4886782,rs56363908,rs6546231,rs6949451,rs800703,rs985036 |
| Average_Forearm | Glaucoma | VII Diseases of the eye and adnexa (H7_) | Inverse variance weighted (multiplicative random effects) | 21 | -50.46 | 31.07 | 1.04E-01 | 0.55 | rs11022507,rs11965043,rs12685003,rs13726,rs149299821,rs1769758,rs1966265,rs2306937,rs2395617,rs2627692,rs35675358,rs3817428,rs4622705,rs4800452,rs4842841,rs4886782,rs56363908,rs6546231,rs6949451,rs800703,rs985036 |
| Average_Forearm | Glaucoma | VII Diseases of the eye and adnexa (H7_) | Weighted mode | 21 | -13.60 | 25.94 | 6.06E-01 | 0.55 | rs11022507,rs11965043,rs12685003,rs13726,rs149299821,rs1769758,rs1966265,rs2306937,rs2395617,rs2627692,rs35675358,rs3817428,rs4622705,rs4800452,rs4842841,rs4886782,rs56363908,rs6546231,rs6949451,rs800703,rs985036 |
| Average_Forearm | Glaucoma | VII Diseases of the eye and adnexa (H7_) | Weighted median | 21 | -15.33 | 17.20 | 3.73E-01 | 0.55 | rs11022507,rs11965043,rs12685003,rs13726,rs149299821,rs1769758,rs1966265,rs2306937,rs2395617,rs2627692,rs35675358,rs3817428,rs4622705,rs4800452,rs4842841,rs4886782,rs56363908,rs6546231,rs6949451,rs800703,rs985036 |
| Average_Forearm | Glaucoma | VII Diseases of the eye and adnexa (H7_) | DIVW | 21 | -51.66 | 11.03 | 1.42E-06 | 0.55 | rs11022507,rs11965043,rs12685003,rs13726,rs149299821,rs1769758,rs1966265,rs2306937,rs2395617,rs2627692,rs35675358,rs3817428,rs4622705,rs4800452,rs4842841,rs4886782,rs56363908,rs6546231,rs6949451,rs800703,rs985036 |
| Average_Forearm | Glaucoma | VII Diseases of the eye and adnexa (H7_) | GRAPPLE | 21 | -22.43 | 20.35 | 2.70E-01 | 0.55 | rs11022507,rs11965043,rs12685003,rs13726,rs149299821,rs1769758,rs1966265,rs2306937,rs2395617,rs2627692,rs35675358,rs3817428,rs4622705,rs4800452,rs4842841,rs4886782,rs56363908,rs6546231,rs6949451,rs800703,rs985036 |
| Average_Forearm | Glaucoma | VII Diseases of the eye and adnexa (H7_) | mr_raps | 21 | -26.06 | 10.14 | 1.02E-02 | 0.55 | rs11022507,rs11965043,rs12685003,rs13726,rs149299821,rs1769758,rs1966265,rs2306937,rs2395617,rs2627692,rs35675358,rs3817428,rs4622705,rs4800452,rs4842841,rs4886782,rs56363908,rs6546231,rs6949451,rs800703,rs985036 |
| Average_Forearm | Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | MR Egger | 21 | 13.42 | 43.15 | 7.59E-01 | 0.77 | rs11022507,rs11965043,rs12685003,rs13726,rs149299821,rs1769758,rs1966265,rs2306937,rs2395617,rs2627692,rs35675358,rs3817428,rs4622705,rs4800452,rs4842841,rs4886782,rs56363908,rs6546231,rs6949451,rs800703,rs985036 |
| Average_Forearm | Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | Inverse variance weighted (fixed effects) | 21 | 25.77 | 6.46 | 6.57E-05 | 0.77 | rs11022507,rs11965043,rs12685003,rs13726,rs149299821,rs1769758,rs1966265,rs2306937,rs2395617,rs2627692,rs35675358,rs3817428,rs4622705,rs4800452,rs4842841,rs4886782,rs56363908,rs6546231,rs6949451,rs800703,rs985036 |
| Average_Forearm | Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | Inverse variance weighted (multiplicative random effects) | 21 | 25.77 | 9.92 | 9.35E-03 | 0.77 | rs11022507,rs11965043,rs12685003,rs13726,rs149299821,rs1769758,rs1966265,rs2306937,rs2395617,rs2627692,rs35675358,rs3817428,rs4622705,rs4800452,rs4842841,rs4886782,rs56363908,rs6546231,rs6949451,rs800703,rs985036 |
| Average_Forearm | Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | Weighted mode | 21 | -2.35 | 21.18 | 9.13E-01 | 0.77 | rs11022507,rs11965043,rs12685003,rs13726,rs149299821,rs1769758,rs1966265,rs2306937,rs2395617,rs2627692,rs35675358,rs3817428,rs4622705,rs4800452,rs4842841,rs4886782,rs56363908,rs6546231,rs6949451,rs800703,rs985036 |
| Average_Forearm | Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | Weighted median | 21 | 18.71 | 10.66 | 7.93E-02 | 0.77 | rs11022507,rs11965043,rs12685003,rs13726,rs149299821,rs1769758,rs1966265,rs2306937,rs2395617,rs2627692,rs35675358,rs3817428,rs4622705,rs4800452,rs4842841,rs4886782,rs56363908,rs6546231,rs6949451,rs800703,rs985036 |
| Average_Forearm | Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | DIVW | 21 | 26.38 | 6.67 | 3.86E-05 | 0.77 | rs11022507,rs11965043,rs12685003,rs13726,rs149299821,rs1769758,rs1966265,rs2306937,rs2395617,rs2627692,rs35675358,rs3817428,rs4622705,rs4800452,rs4842841,rs4886782,rs56363908,rs6546231,rs6949451,rs800703,rs985036 |
| Average_Forearm | Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | GRAPPLE | 21 | 22.05 | 10.52 | 3.61E-02 | 0.77 | rs11022507,rs11965043,rs12685003,rs13726,rs149299821,rs1769758,rs1966265,rs2306937,rs2395617,rs2627692,rs35675358,rs3817428,rs4622705,rs4800452,rs4842841,rs4886782,rs56363908,rs6546231,rs6949451,rs800703,rs985036 |
| Average_Forearm | Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | mr_raps | 21 | 24.34 | 6.72 | 2.91E-04 | 0.77 | rs11022507,rs11965043,rs12685003,rs13726,rs149299821,rs1769758,rs1966265,rs2306937,rs2395617,rs2627692,rs35675358,rs3817428,rs4622705,rs4800452,rs4842841,rs4886782,rs56363908,rs6546231,rs6949451,rs800703,rs985036 |
| Average_Humerus | Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | MR Egger | 27 | 39.24 | 20.71 | 6.97E-02 | 0.26 | rs11205277,rs12450214,rs12790261,rs142106866,rs143384,rs1469069,rs16854114,rs1859163,rs1927696,rs2045839,rs2123184,rs2326844,rs2690720,rs34466731,rs3741760,rs3817428,rs3825199,rs4075733,rs42064,rs4544515,rs5029277,rs56090709,rs62541927,rs6503984,rs6816817,rs7704555,rs7720861 |
| Average_Humerus | Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | Inverse variance weighted (fixed effects) | 27 | 16.89 | 4.06 | 3.13E-05 | 0.26 | rs11205277,rs12450214,rs12790261,rs142106866,rs143384,rs1469069,rs16854114,rs1859163,rs1927696,rs2045839,rs2123184,rs2326844,rs2690720,rs34466731,rs3741760,rs3817428,rs3825199,rs4075733,rs42064,rs4544515,rs5029277,rs56090709,rs62541927,rs6503984,rs6816817,rs7704555,rs7720861 |
| Average_Humerus | Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | Inverse variance weighted (multiplicative random effects) | 27 | 16.89 | 7.13 | 1.79E-02 | 0.26 | rs11205277,rs12450214,rs12790261,rs142106866,rs143384,rs1469069,rs16854114,rs1859163,rs1927696,rs2045839,rs2123184,rs2326844,rs2690720,rs34466731,rs3741760,rs3817428,rs3825199,rs4075733,rs42064,rs4544515,rs5029277,rs56090709,rs62541927,rs6503984,rs6816817,rs7704555,rs7720861 |
| Average_Humerus | Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | Weighted mode | 27 | 15.07 | 8.46 | 8.65E-02 | 0.26 | rs11205277,rs12450214,rs12790261,rs142106866,rs143384,rs1469069,rs16854114,rs1859163,rs1927696,rs2045839,rs2123184,rs2326844,rs2690720,rs34466731,rs3741760,rs3817428,rs3825199,rs4075733,rs42064,rs4544515,rs5029277,rs56090709,rs62541927,rs6503984,rs6816817,rs7704555,rs7720861 |
| Average_Humerus | Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | Weighted median | 27 | 16.70 | 6.82 | 1.43E-02 | 0.26 | rs11205277,rs12450214,rs12790261,rs142106866,rs143384,rs1469069,rs16854114,rs1859163,rs1927696,rs2045839,rs2123184,rs2326844,rs2690720,rs34466731,rs3741760,rs3817428,rs3825199,rs4075733,rs42064,rs4544515,rs5029277,rs56090709,rs62541927,rs6503984,rs6816817,rs7704555,rs7720861 |
| Average_Humerus | Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | DIVW | 27 | 17.21 | 4.16 | 1.76E-05 | 0.26 | rs11205277,rs12450214,rs12790261,rs142106866,rs143384,rs1469069,rs16854114,rs1859163,rs1927696,rs2045839,rs2123184,rs2326844,rs2690720,rs34466731,rs3741760,rs3817428,rs3825199,rs4075733,rs42064,rs4544515,rs5029277,rs56090709,rs62541927,rs6503984,rs6816817,rs7704555,rs7720861 |
| Average_Humerus | Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | GRAPPLE | 27 | 20.15 | 7.24 | 5.41E-03 | 0.26 | rs11205277,rs12450214,rs12790261,rs142106866,rs143384,rs1469069,rs16854114,rs1859163,rs1927696,rs2045839,rs2123184,rs2326844,rs2690720,rs34466731,rs3741760,rs3817428,rs3825199,rs4075733,rs42064,rs4544515,rs5029277,rs56090709,rs62541927,rs6503984,rs6816817,rs7704555,rs7720861 |
| Average_Humerus | Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | mr_raps | 27 | 18.03 | 4.19 | 1.69E-05 | 0.26 | rs11205277,rs12450214,rs12790261,rs142106866,rs143384,rs1469069,rs16854114,rs1859163,rs1927696,rs2045839,rs2123184,rs2326844,rs2690720,rs34466731,rs3741760,rs3817428,rs3825199,rs4075733,rs42064,rs4544515,rs5029277,rs56090709,rs62541927,rs6503984,rs6816817,rs7704555,rs7720861 |
| Average_Tibia | Coxarthrosis [arthrosis of hip](FG) | Rheuma endpoints | MR Egger | 31 | 102.64 | 36.37 | 8.54E-03 | 0.06 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Coxarthrosis [arthrosis of hip](FG) | Rheuma endpoints | Inverse variance weighted (fixed effects) | 31 | 34.97 | 5.84 | 2.11E-09 | 0.06 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Coxarthrosis [arthrosis of hip](FG) | Rheuma endpoints | Inverse variance weighted (multiplicative random effects) | 31 | 34.97 | 10.07 | 5.15E-04 | 0.06 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Coxarthrosis [arthrosis of hip](FG) | Rheuma endpoints | Weighted mode | 31 | 36.36 | 16.62 | 3.66E-02 | 0.06 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Coxarthrosis [arthrosis of hip](FG) | Rheuma endpoints | Weighted median | 31 | 30.03 | 9.45 | 1.48E-03 | 0.06 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Coxarthrosis [arthrosis of hip](FG) | Rheuma endpoints | DIVW | 31 | 35.71 | 6.04 | 1.68E-09 | 0.06 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Coxarthrosis [arthrosis of hip](FG) | Rheuma endpoints | GRAPPLE | 31 | 39.71 | 11.07 | 3.36E-04 | 0.06 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Coxarthrosis [arthrosis of hip](FG) | Rheuma endpoints | mr_raps | 31 | 36.00 | 6.07 | 3.11E-09 | 0.06 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | MR Egger | 31 | 32.49 | 25.45 | 2.12E-01 | 0.48 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | Inverse variance weighted (fixed effects) | 31 | 14.91 | 3.80 | 8.60E-05 | 0.48 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | Inverse variance weighted (multiplicative random effects) | 31 | 14.91 | 6.74 | 2.70E-02 | 0.48 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | Weighted mode | 31 | 20.57 | 7.94 | 1.46E-02 | 0.48 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | Weighted median | 31 | 19.00 | 5.93 | 1.37E-03 | 0.48 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | DIVW | 31 | 15.23 | 3.90 | 4.70E-05 | 0.48 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | GRAPPLE | 31 | 15.23 | 6.67 | 2.25E-02 | 0.48 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | mr_raps | 31 | 16.61 | 3.92 | 2.29E-05 | 0.48 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Hypertension | IX Diseases of the circulatory system (I9_) | MR Egger | 31 | 21.54 | 30.45 | 4.85E-01 | 0.20 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Hypertension | IX Diseases of the circulatory system (I9_) | Inverse variance weighted (fixed effects) | 31 | -16.51 | 3.17 | 1.97E-07 | 0.20 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Hypertension | IX Diseases of the circulatory system (I9_) | Inverse variance weighted (multiplicative random effects) | 31 | -16.51 | 8.23 | 4.48E-02 | 0.20 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Hypertension | IX Diseases of the circulatory system (I9_) | Weighted mode | 31 | -6.54 | 7.20 | 3.71E-01 | 0.20 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Hypertension | IX Diseases of the circulatory system (I9_) | Weighted median | 31 | -6.46 | 5.03 | 1.99E-01 | 0.20 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Hypertension | IX Diseases of the circulatory system (I9_) | DIVW | 31 | -16.86 | 3.27 | 1.29E-07 | 0.20 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Hypertension | IX Diseases of the circulatory system (I9_) | GRAPPLE | 31 | -10.01 | 6.52 | 1.25E-01 | 0.20 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Hypertension | IX Diseases of the circulatory system (I9_) | mr_raps | 31 | -10.32 | 3.14 | 1.03E-03 | 0.20 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Gonarthrosis [arthrosis of knee](FG) | Rheuma endpoints | MR Egger | 31 | 57.14 | 29.18 | 5.99E-02 | 0.22 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Gonarthrosis [arthrosis of knee](FG) | Rheuma endpoints | Inverse variance weighted (fixed effects) | 31 | 21.67 | 4.24 | 3.18E-07 | 0.22 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Gonarthrosis [arthrosis of knee](FG) | Rheuma endpoints | Inverse variance weighted (multiplicative random effects) | 31 | 21.67 | 7.85 | 5.74E-03 | 0.22 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Gonarthrosis [arthrosis of knee](FG) | Rheuma endpoints | Weighted mode | 31 | 19.90 | 12.75 | 1.29E-01 | 0.22 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Gonarthrosis [arthrosis of knee](FG) | Rheuma endpoints | Weighted median | 31 | 19.39 | 7.17 | 6.88E-03 | 0.22 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Gonarthrosis [arthrosis of knee](FG) | Rheuma endpoints | DIVW | 31 | 22.13 | 4.37 | 2.04E-07 | 0.22 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Gonarthrosis [arthrosis of knee](FG) | Rheuma endpoints | GRAPPLE | 31 | 27.36 | 8.39 | 1.12E-03 | 0.22 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Gonarthrosis [arthrosis of knee](FG) | Rheuma endpoints | mr_raps | 31 | 26.47 | 4.41 | 1.96E-09 | 0.22 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Female genital prolapse | XIV Diseases of the genitourinary system (N14_) | MR Egger | 31 | 30.48 | 45.74 | 5.10E-01 | 0.97 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Female genital prolapse | XIV Diseases of the genitourinary system (N14_) | Inverse variance weighted (fixed effects) | 31 | 28.83 | 6.85 | 2.58E-05 | 0.97 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Female genital prolapse | XIV Diseases of the genitourinary system (N14_) | Inverse variance weighted (multiplicative random effects) | 31 | 28.83 | 12.03 | 1.65E-02 | 0.97 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Female genital prolapse | XIV Diseases of the genitourinary system (N14_) | Weighted mode | 31 | -4.72 | 22.90 | 8.38E-01 | 0.97 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Female genital prolapse | XIV Diseases of the genitourinary system (N14_) | Weighted median | 31 | 8.64 | 10.53 | 4.12E-01 | 0.97 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Female genital prolapse | XIV Diseases of the genitourinary system (N14_) | DIVW | 31 | 29.45 | 7.04 | 1.45E-05 | 0.97 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Female genital prolapse | XIV Diseases of the genitourinary system (N14_) | GRAPPLE | 31 | 19.93 | 11.55 | 8.44E-02 | 0.97 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Female genital prolapse | XIV Diseases of the genitourinary system (N14_) | mr_raps | 31 | 19.59 | 7.02 | 5.25E-03 | 0.97 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Finngen Rheumatological endpoints | Rheuma endpoints | MR Egger | 31 | 57.48 | 18.43 | 4.08E-03 | 0.02 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Finngen Rheumatological endpoints | Rheuma endpoints | Inverse variance weighted (fixed effects) | 31 | 13.13 | 3.13 | 2.74E-05 | 0.02 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Finngen Rheumatological endpoints | Rheuma endpoints | Inverse variance weighted (multiplicative random effects) | 31 | 13.13 | 5.33 | 1.37E-02 | 0.02 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Finngen Rheumatological endpoints | Rheuma endpoints | Weighted mode | 31 | 18.52 | 8.49 | 3.71E-02 | 0.02 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Finngen Rheumatological endpoints | Rheuma endpoints | Weighted median | 31 | 15.25 | 5.00 | 2.28E-03 | 0.02 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Finngen Rheumatological endpoints | Rheuma endpoints | DIVW | 31 | 13.41 | 3.22 | 1.54E-05 | 0.02 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Finngen Rheumatological endpoints | Rheuma endpoints | GRAPPLE | 31 | 17.35 | 5.58 | 1.89E-03 | 0.02 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Average_Tibia | Finngen Rheumatological endpoints | Rheuma endpoints | mr_raps | 31 | 18.15 | 3.27 | 2.84E-08 | 0.02 | rs10774625,rs11205277,rs11695471,rs11722554,rs11913403,rs12042083,rs1207718,rs12738523,rs13233149,rs1589163,rs162495,rs1966265,rs2026806,rs2270406,rs2270707,rs2281393,rs2836288,rs2853361,rs2854747,rs4245909,rs435581,rs4421120,rs4800452,rs55748710,rs59985551,rs61146205,rs62576756,rs7214743,rs7660200,rs7952436,rs979012 |
| Shoulder_Width | Asthma (mode) | Interstitial lung disease endpoints | MR Egger | 15 | -8.27 | 40.08 | 8.40E-01 | 0.49 | rs10786695,rs11049793,rs111251222,rs12149906,rs1231208,rs17684959,rs1838619,rs1949978,rs2145270,rs2526303,rs4308051,rs62449291,rs68052435,rs913835,rs9924314 |
| Shoulder_Width | Asthma (mode) | Interstitial lung disease endpoints | Inverse variance weighted (fixed effects) | 15 | 19.85 | 4.54 | 1.22E-05 | 0.49 | rs10786695,rs11049793,rs111251222,rs12149906,rs1231208,rs17684959,rs1838619,rs1949978,rs2145270,rs2526303,rs4308051,rs62449291,rs68052435,rs913835,rs9924314 |
| Shoulder_Width | Asthma (mode) | Interstitial lung disease endpoints | Inverse variance weighted (multiplicative random effects) | 15 | 19.85 | 6.68 | 2.97E-03 | 0.49 | rs10786695,rs11049793,rs111251222,rs12149906,rs1231208,rs17684959,rs1838619,rs1949978,rs2145270,rs2526303,rs4308051,rs62449291,rs68052435,rs913835,rs9924314 |
| Shoulder_Width | Asthma (mode) | Interstitial lung disease endpoints | Weighted mode | 15 | 24.29 | 11.21 | 4.80E-02 | 0.49 | rs10786695,rs11049793,rs111251222,rs12149906,rs1231208,rs17684959,rs1838619,rs1949978,rs2145270,rs2526303,rs4308051,rs62449291,rs68052435,rs913835,rs9924314 |
| Shoulder_Width | Asthma (mode) | Interstitial lung disease endpoints | Weighted median | 15 | 20.53 | 6.64 | 1.99E-03 | 0.49 | rs10786695,rs11049793,rs111251222,rs12149906,rs1231208,rs17684959,rs1838619,rs1949978,rs2145270,rs2526303,rs4308051,rs62449291,rs68052435,rs913835,rs9924314 |
| Shoulder_Width | Asthma (mode) | Interstitial lung disease endpoints | DIVW | 15 | 20.34 | 4.73 | 8.41E-06 | 0.49 | rs10786695,rs11049793,rs111251222,rs12149906,rs1231208,rs17684959,rs1838619,rs1949978,rs2145270,rs2526303,rs4308051,rs62449291,rs68052435,rs913835,rs9924314 |
| Shoulder_Width | Asthma (mode) | Interstitial lung disease endpoints | GRAPPLE | 15 | 18.11 | 6.88 | 8.45E-03 | 0.49 | rs10786695,rs11049793,rs111251222,rs12149906,rs1231208,rs17684959,rs1838619,rs1949978,rs2145270,rs2526303,rs4308051,rs62449291,rs68052435,rs913835,rs9924314 |
| Shoulder_Width | Asthma (mode) | Interstitial lung disease endpoints | mr_raps | 15 | 18.48 | 4.76 | 1.01E-04 | 0.49 | rs10786695,rs11049793,rs111251222,rs12149906,rs1231208,rs17684959,rs1838619,rs1949978,rs2145270,rs2526303,rs4308051,rs62449291,rs68052435,rs913835,rs9924314 |
| Shoulder_Width | Diseases of the eye and adnexa | VII Diseases of the eye and adnexa (H7_) | MR Egger | 15 | 4.00 | 24.19 | 8.71E-01 | 0.74 | rs10786695,rs11049793,rs111251222,rs12149906,rs1231208,rs17684959,rs1838619,rs1949978,rs2145270,rs2526303,rs4308051,rs62449291,rs68052435,rs913835,rs9924314 |
| Shoulder_Width | Diseases of the eye and adnexa | VII Diseases of the eye and adnexa (H7_) | Inverse variance weighted (fixed effects) | 15 | 12.05 | 2.89 | 3.11E-05 | 0.74 | rs10786695,rs11049793,rs111251222,rs12149906,rs1231208,rs17684959,rs1838619,rs1949978,rs2145270,rs2526303,rs4308051,rs62449291,rs68052435,rs913835,rs9924314 |
| Shoulder_Width | Diseases of the eye and adnexa | VII Diseases of the eye and adnexa (H7_) | Inverse variance weighted (multiplicative random effects) | 15 | 12.05 | 3.97 | 2.40E-03 | 0.74 | rs10786695,rs11049793,rs111251222,rs12149906,rs1231208,rs17684959,rs1838619,rs1949978,rs2145270,rs2526303,rs4308051,rs62449291,rs68052435,rs913835,rs9924314 |
| Shoulder_Width | Diseases of the eye and adnexa | VII Diseases of the eye and adnexa (H7_) | Weighted mode | 15 | -0.65 | 8.64 | 9.41E-01 | 0.74 | rs10786695,rs11049793,rs111251222,rs12149906,rs1231208,rs17684959,rs1838619,rs1949978,rs2145270,rs2526303,rs4308051,rs62449291,rs68052435,rs913835,rs9924314 |
| Shoulder_Width | Diseases of the eye and adnexa | VII Diseases of the eye and adnexa (H7_) | Weighted median | 15 | 5.29 | 4.75 | 2.66E-01 | 0.74 | rs10786695,rs11049793,rs111251222,rs12149906,rs1231208,rs17684959,rs1838619,rs1949978,rs2145270,rs2526303,rs4308051,rs62449291,rs68052435,rs913835,rs9924314 |
| Shoulder_Width | Diseases of the eye and adnexa | VII Diseases of the eye and adnexa (H7_) | DIVW | 15 | 12.36 | 3.01 | 2.03E-05 | 0.74 | rs10786695,rs11049793,rs111251222,rs12149906,rs1231208,rs17684959,rs1838619,rs1949978,rs2145270,rs2526303,rs4308051,rs62449291,rs68052435,rs913835,rs9924314 |
| Shoulder_Width | Diseases of the eye and adnexa | VII Diseases of the eye and adnexa (H7_) | GRAPPLE | 15 | 11.60 | 4.20 | 5.75E-03 | 0.74 | rs10786695,rs11049793,rs111251222,rs12149906,rs1231208,rs17684959,rs1838619,rs1949978,rs2145270,rs2526303,rs4308051,rs62449291,rs68052435,rs913835,rs9924314 |
| Shoulder_Width | Diseases of the eye and adnexa | VII Diseases of the eye and adnexa (H7_) | mr_raps | 15 | 12.71 | 3.07 | 3.39E-05 | 0.74 | rs10786695,rs11049793,rs111251222,rs12149906,rs1231208,rs17684959,rs1838619,rs1949978,rs2145270,rs2526303,rs4308051,rs62449291,rs68052435,rs913835,rs9924314 |
| Torso_Length | Coronary angiopasty | IX Diseases of the circulatory system (I9_) | MR Egger | 9 | 42.10 | 56.31 | 4.79E-01 | 0.96 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Coronary angiopasty | IX Diseases of the circulatory system (I9_) | Inverse variance weighted (fixed effects) | 9 | 38.85 | 8.27 | 2.65E-06 | 0.96 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Coronary angiopasty | IX Diseases of the circulatory system (I9_) | Inverse variance weighted (multiplicative random effects) | 9 | 38.85 | 6.86 | 1.51E-08 | 0.96 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Coronary angiopasty | IX Diseases of the circulatory system (I9_) | Weighted mode | 9 | 48.87 | 18.05 | 2.68E-02 | 0.96 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Coronary angiopasty | IX Diseases of the circulatory system (I9_) | Weighted median | 9 | 42.83 | 10.97 | 9.45E-05 | 0.96 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Coronary angiopasty | IX Diseases of the circulatory system (I9_) | DIVW | 9 | 39.88 | 8.78 | 2.78E-06 | 0.96 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Coronary angiopasty | IX Diseases of the circulatory system (I9_) | GRAPPLE | 9 | 39.81 | 8.92 | 8.13E-06 | 0.96 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Coronary angiopasty | IX Diseases of the circulatory system (I9_) | mr_raps | 9 | 39.44 | 9.04 | 1.27E-05 | 0.96 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Major coronary heart disease event | IX Diseases of the circulatory system (I9_) | MR Egger | 9 | 21.23 | 36.03 | 5.74E-01 | 0.86 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Major coronary heart disease event | IX Diseases of the circulatory system (I9_) | Inverse variance weighted (fixed effects) | 9 | 27.90 | 5.29 | 1.35E-07 | 0.86 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Major coronary heart disease event | IX Diseases of the circulatory system (I9_) | Inverse variance weighted (multiplicative random effects) | 9 | 27.90 | 4.86 | 9.57E-09 | 0.86 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Major coronary heart disease event | IX Diseases of the circulatory system (I9_) | Weighted mode | 9 | 23.32 | 10.63 | 5.95E-02 | 0.86 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Major coronary heart disease event | IX Diseases of the circulatory system (I9_) | Weighted median | 9 | 22.80 | 7.11 | 1.34E-03 | 0.86 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Major coronary heart disease event | IX Diseases of the circulatory system (I9_) | DIVW | 9 | 28.64 | 5.66 | 2.13E-07 | 0.86 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Major coronary heart disease event | IX Diseases of the circulatory system (I9_) | GRAPPLE | 9 | 28.28 | 5.77 | 9.38E-07 | 0.86 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Major coronary heart disease event | IX Diseases of the circulatory system (I9_) | mr_raps | 9 | 28.55 | 5.81 | 9.05E-07 | 0.86 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Coronary atherosclerosis | IX Diseases of the circulatory system (I9_) | MR Egger | 9 | 1.07 | 35.70 | 9.77E-01 | 0.56 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Coronary atherosclerosis | IX Diseases of the circulatory system (I9_) | Inverse variance weighted (fixed effects) | 9 | 22.94 | 5.25 | 1.22E-05 | 0.56 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Coronary atherosclerosis | IX Diseases of the circulatory system (I9_) | Inverse variance weighted (multiplicative random effects) | 9 | 22.94 | 4.82 | 1.94E-06 | 0.56 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Coronary atherosclerosis | IX Diseases of the circulatory system (I9_) | Weighted mode | 9 | 32.15 | 11.32 | 2.18E-02 | 0.56 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Coronary atherosclerosis | IX Diseases of the circulatory system (I9_) | Weighted median | 9 | 24.82 | 7.05 | 4.33E-04 | 0.56 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Coronary atherosclerosis | IX Diseases of the circulatory system (I9_) | DIVW | 9 | 23.56 | 5.54 | 1.07E-05 | 0.56 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Coronary atherosclerosis | IX Diseases of the circulatory system (I9_) | GRAPPLE | 9 | 23.69 | 5.67 | 2.89E-05 | 0.56 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Coronary atherosclerosis | IX Diseases of the circulatory system (I9_) | mr_raps | 9 | 23.57 | 5.70 | 3.56E-05 | 0.56 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Hard cardiovascular diseases | Cardiometabolic endpoints | MR Egger | 9 | 24.91 | 32.27 | 4.65E-01 | 0.89 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Hard cardiovascular diseases | Cardiometabolic endpoints | Inverse variance weighted (fixed effects) | 9 | 20.24 | 4.64 | 1.30E-05 | 0.89 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Hard cardiovascular diseases | Cardiometabolic endpoints | Inverse variance weighted (multiplicative random effects) | 9 | 20.24 | 4.44 | 5.22E-06 | 0.89 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Hard cardiovascular diseases | Cardiometabolic endpoints | Weighted mode | 9 | 18.12 | 9.58 | 9.53E-02 | 0.89 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Hard cardiovascular diseases | Cardiometabolic endpoints | Weighted median | 9 | 18.79 | 6.16 | 2.30E-03 | 0.89 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Hard cardiovascular diseases | Cardiometabolic endpoints | DIVW | 9 | 20.78 | 4.90 | 1.14E-05 | 0.89 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Hard cardiovascular diseases | Cardiometabolic endpoints | GRAPPLE | 9 | 20.23 | 5.00 | 5.15E-05 | 0.89 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Hard cardiovascular diseases | Cardiometabolic endpoints | mr_raps | 9 | 20.08 | 5.02 | 6.39E-05 | 0.89 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Ischemic heart diseases | IX Diseases of the circulatory system (I9_) | MR Egger | 9 | -15.06 | 31.23 | 6.44E-01 | 0.32 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Ischemic heart diseases | IX Diseases of the circulatory system (I9_) | Inverse variance weighted (fixed effects) | 9 | 18.30 | 4.59 | 6.64E-05 | 0.32 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Ischemic heart diseases | IX Diseases of the circulatory system (I9_) | Inverse variance weighted (multiplicative random effects) | 9 | 18.30 | 4.35 | 2.54E-05 | 0.32 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Ischemic heart diseases | IX Diseases of the circulatory system (I9_) | Weighted mode | 9 | 10.40 | 9.56 | 3.08E-01 | 0.32 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Ischemic heart diseases | IX Diseases of the circulatory system (I9_) | Weighted median | 9 | 13.96 | 6.37 | 2.85E-02 | 0.32 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Ischemic heart diseases | IX Diseases of the circulatory system (I9_) | DIVW | 9 | 18.79 | 4.83 | 4.94E-05 | 0.32 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Ischemic heart diseases | IX Diseases of the circulatory system (I9_) | GRAPPLE | 9 | 18.17 | 4.92 | 2.20E-04 | 0.32 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Ischemic heart diseases | IX Diseases of the circulatory system (I9_) | mr_raps | 9 | 18.17 | 4.95 | 2.38E-04 | 0.32 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Myocardial infarction | IX Diseases of the circulatory system (I9_) | MR Egger | 9 | 55.65 | 45.61 | 2.62E-01 | 0.60 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Myocardial infarction | IX Diseases of the circulatory system (I9_) | Inverse variance weighted (fixed effects) | 9 | 31.00 | 6.71 | 3.80E-06 | 0.60 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Myocardial infarction | IX Diseases of the circulatory system (I9_) | Inverse variance weighted (multiplicative random effects) | 9 | 31.00 | 6.25 | 7.08E-07 | 0.60 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Myocardial infarction | IX Diseases of the circulatory system (I9_) | Weighted mode | 9 | 31.07 | 13.07 | 4.48E-02 | 0.60 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Myocardial infarction | IX Diseases of the circulatory system (I9_) | Weighted median | 9 | 31.70 | 9.07 | 4.75E-04 | 0.60 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Myocardial infarction | IX Diseases of the circulatory system (I9_) | DIVW | 9 | 31.82 | 7.11 | 3.81E-06 | 0.60 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Myocardial infarction | IX Diseases of the circulatory system (I9_) | GRAPPLE | 9 | 31.54 | 7.24 | 1.33E-05 | 0.60 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| Torso_Length | Myocardial infarction | IX Diseases of the circulatory system (I9_) | mr_raps | 9 | 31.39 | 7.30 | 1.73E-05 | 0.60 | rs1173734,rs1891308,rs2854747,rs4241406,rs4800452,rs61146205,rs6663322,rs7214743,rs979012 |
| id.exposure | exp.category | id.outcome | method | nsnp | b | se | pval | MR-Egger intercept Pvalue | snps |
|---|---|---|---|---|---|---|---|---|---|
| Carpal tunnel syndrome | VI Diseases of the nervous system (G6_) | Average_Forearm | MR Egger | 18 | 3.42E-05 | 9.87E-04 | 9.73E-01 | 0.45 | rs1121980,rs11241524,rs11577617,rs11588850,rs1720021,rs17568616,rs2090492,rs2113825,rs28929474,rs4531365,rs502360,rs58210908,rs6543373,rs6963178,rs72786750,rs73165545,rs7562101,rs9273367 |
| Carpal tunnel syndrome | VI Diseases of the nervous system (G6_) | Average_Forearm | Inverse variance weighted (fixed effects) | 18 | 7.78E-04 | 1.44E-04 | 6.18E-08 | 0.45 | rs1121980,rs11241524,rs11577617,rs11588850,rs1720021,rs17568616,rs2090492,rs2113825,rs28929474,rs4531365,rs502360,rs58210908,rs6543373,rs6963178,rs72786750,rs73165545,rs7562101,rs9273367 |
| Carpal tunnel syndrome | VI Diseases of the nervous system (G6_) | Average_Forearm | Inverse variance weighted (multiplicative random effects) | 18 | 7.78E-04 | 2.14E-04 | 2.83E-04 | 0.45 | rs1121980,rs11241524,rs11577617,rs11588850,rs1720021,rs17568616,rs2090492,rs2113825,rs28929474,rs4531365,rs502360,rs58210908,rs6543373,rs6963178,rs72786750,rs73165545,rs7562101,rs9273367 |
| Carpal tunnel syndrome | VI Diseases of the nervous system (G6_) | Average_Forearm | Weighted mode | 18 | 1.48E-04 | 4.66E-04 | 7.54E-01 | 0.45 | rs1121980,rs11241524,rs11577617,rs11588850,rs1720021,rs17568616,rs2090492,rs2113825,rs28929474,rs4531365,rs502360,rs58210908,rs6543373,rs6963178,rs72786750,rs73165545,rs7562101,rs9273367 |
| Carpal tunnel syndrome | VI Diseases of the nervous system (G6_) | Average_Forearm | Weighted median | 18 | 7.09E-04 | 2.37E-04 | 2.78E-03 | 0.45 | rs1121980,rs11241524,rs11577617,rs11588850,rs1720021,rs17568616,rs2090492,rs2113825,rs28929474,rs4531365,rs502360,rs58210908,rs6543373,rs6963178,rs72786750,rs73165545,rs7562101,rs9273367 |
| Carpal tunnel syndrome | VI Diseases of the nervous system (G6_) | Average_Forearm | DIVW | 18 | 8.00E-04 | 1.51E-04 | 6.25E-08 | 0.45 | rs1121980,rs11241524,rs11577617,rs11588850,rs1720021,rs17568616,rs2090492,rs2113825,rs28929474,rs4531365,rs502360,rs58210908,rs6543373,rs6963178,rs72786750,rs73165545,rs7562101,rs9273367 |
| Carpal tunnel syndrome | VI Diseases of the nervous system (G6_) | Average_Forearm | GRAPPLE | 18 | 7.60E-04 | 2.26E-04 | 7.86E-04 | 0.45 | rs1121980,rs11241524,rs11577617,rs11588850,rs1720021,rs17568616,rs2090492,rs2113825,rs28929474,rs4531365,rs502360,rs58210908,rs6543373,rs6963178,rs72786750,rs73165545,rs7562101,rs9273367 |
| Carpal tunnel syndrome | VI Diseases of the nervous system (G6_) | Average_Forearm | mr_raps | 18 | 8.37E-04 | 1.53E-04 | 4.92E-08 | 0.45 | rs1121980,rs11241524,rs11577617,rs11588850,rs1720021,rs17568616,rs2090492,rs2113825,rs28929474,rs4531365,rs502360,rs58210908,rs6543373,rs6963178,rs72786750,rs73165545,rs7562101,rs9273367 |
| Nerve, nerve root and plexus disorders | VI Diseases of the nervous system (G6_) | Average_Tibia | MR Egger | 7 | -3.24E-03 | 3.06E-03 | 3.37E-01 | 0.15 | rs1121980,rs1383258,rs1720021,rs4959105,rs72836480,rs73082331,rs9273367 |
| Nerve, nerve root and plexus disorders | VI Diseases of the nervous system (G6_) | Average_Tibia | Inverse variance weighted (fixed effects) | 7 | 1.78E-03 | 4.25E-04 | 2.78E-05 | 0.15 | rs1121980,rs1383258,rs1720021,rs4959105,rs72836480,rs73082331,rs9273367 |
| Nerve, nerve root and plexus disorders | VI Diseases of the nervous system (G6_) | Average_Tibia | Inverse variance weighted (multiplicative random effects) | 7 | 1.78E-03 | 8.19E-04 | 2.97E-02 | 0.15 | rs1121980,rs1383258,rs1720021,rs4959105,rs72836480,rs73082331,rs9273367 |
| Nerve, nerve root and plexus disorders | VI Diseases of the nervous system (G6_) | Average_Tibia | Weighted mode | 7 | 4.82E-04 | 7.32E-04 | 5.34E-01 | 0.15 | rs1121980,rs1383258,rs1720021,rs4959105,rs72836480,rs73082331,rs9273367 |
| Nerve, nerve root and plexus disorders | VI Diseases of the nervous system (G6_) | Average_Tibia | Weighted median | 7 | 1.25E-03 | 6.87E-04 | 6.92E-02 | 0.15 | rs1121980,rs1383258,rs1720021,rs4959105,rs72836480,rs73082331,rs9273367 |
| Nerve, nerve root and plexus disorders | VI Diseases of the nervous system (G6_) | Average_Tibia | DIVW | 7 | 1.83E-03 | 4.52E-04 | 2.62E-05 | 0.15 | rs1121980,rs1383258,rs1720021,rs4959105,rs72836480,rs73082331,rs9273367 |
| Nerve, nerve root and plexus disorders | VI Diseases of the nervous system (G6_) | Average_Tibia | GRAPPLE | 7 | 1.63E-03 | 7.92E-04 | 3.99E-02 | 0.15 | rs1121980,rs1383258,rs1720021,rs4959105,rs72836480,rs73082331,rs9273367 |
| Nerve, nerve root and plexus disorders | VI Diseases of the nervous system (G6_) | Average_Tibia | mr_raps | 7 | 1.72E-03 | 4.44E-04 | 1.06E-04 | 0.15 | rs1121980,rs1383258,rs1720021,rs4959105,rs72836480,rs73082331,rs9273367 |
| Sleep apnoea | VI Diseases of the nervous system (G6_) | Average_Forearm | MR Egger | 8 | 3.07E-03 | 1.24E-03 | 4.75E-02 | 0.22 | rs10125995,rs10507084,rs12511115,rs142006783,rs6791437,rs742760,rs76229479,rs9937053 |
| Sleep apnoea | VI Diseases of the nervous system (G6_) | Average_Forearm | Inverse variance weighted (fixed effects) | 8 | 1.43E-03 | 2.55E-04 | 2.01E-08 | 0.22 | rs10125995,rs10507084,rs12511115,rs142006783,rs6791437,rs742760,rs76229479,rs9937053 |
| Sleep apnoea | VI Diseases of the nervous system (G6_) | Average_Forearm | Inverse variance weighted (multiplicative random effects) | 8 | 1.43E-03 | 3.06E-04 | 2.98E-06 | 0.22 | rs10125995,rs10507084,rs12511115,rs142006783,rs6791437,rs742760,rs76229479,rs9937053 |
| Sleep apnoea | VI Diseases of the nervous system (G6_) | Average_Forearm | Weighted mode | 8 | 1.78E-03 | 4.74E-04 | 7.22E-03 | 0.22 | rs10125995,rs10507084,rs12511115,rs142006783,rs6791437,rs742760,rs76229479,rs9937053 |
| Sleep apnoea | VI Diseases of the nervous system (G6_) | Average_Forearm | Weighted median | 8 | 1.60E-03 | 3.54E-04 | 6.35E-06 | 0.22 | rs10125995,rs10507084,rs12511115,rs142006783,rs6791437,rs742760,rs76229479,rs9937053 |
| Sleep apnoea | VI Diseases of the nervous system (G6_) | Average_Forearm | DIVW | 8 | 1.46E-03 | 2.75E-04 | 5.06E-08 | 0.22 | rs10125995,rs10507084,rs12511115,rs142006783,rs6791437,rs742760,rs76229479,rs9937053 |
| Sleep apnoea | VI Diseases of the nervous system (G6_) | Average_Forearm | GRAPPLE | 8 | 1.53E-03 | 3.36E-04 | 5.50E-06 | 0.22 | rs10125995,rs10507084,rs12511115,rs142006783,rs6791437,rs742760,rs76229479,rs9937053 |
| Sleep apnoea | VI Diseases of the nervous system (G6_) | Average_Forearm | mr_raps | 8 | 1.52E-03 | 2.85E-04 | 8.60E-08 | 0.22 | rs10125995,rs10507084,rs12511115,rs142006783,rs6791437,rs742760,rs76229479,rs9937053 |
| Sleep apnoea, including avohilmo | VI Diseases of the nervous system (G6_) | Average_Forearm | MR Egger | 12 | 2.58E-03 | 1.09E-03 | 3.94E-02 | 0.18 | rs10125995,rs1023230,rs10507084,rs12511115,rs12698822,rs142006783,rs2137605,rs28838737,rs4809902,rs76229479,rs7824549,rs9937053 |
| Sleep apnoea, including avohilmo | VI Diseases of the nervous system (G6_) | Average_Forearm | Inverse variance weighted (fixed effects) | 12 | 1.04E-03 | 2.20E-04 | 2.34E-06 | 0.18 | rs10125995,rs1023230,rs10507084,rs12511115,rs12698822,rs142006783,rs2137605,rs28838737,rs4809902,rs76229479,rs7824549,rs9937053 |
| Sleep apnoea, including avohilmo | VI Diseases of the nervous system (G6_) | Average_Forearm | Inverse variance weighted (multiplicative random effects) | 12 | 1.04E-03 | 2.74E-04 | 1.49E-04 | 0.18 | rs10125995,rs1023230,rs10507084,rs12511115,rs12698822,rs142006783,rs2137605,rs28838737,rs4809902,rs76229479,rs7824549,rs9937053 |
| Sleep apnoea, including avohilmo | VI Diseases of the nervous system (G6_) | Average_Forearm | Weighted mode | 12 | 3.02E-04 | 6.73E-04 | 6.62E-01 | 0.18 | rs10125995,rs1023230,rs10507084,rs12511115,rs12698822,rs142006783,rs2137605,rs28838737,rs4809902,rs76229479,rs7824549,rs9937053 |
| Sleep apnoea, including avohilmo | VI Diseases of the nervous system (G6_) | Average_Forearm | Weighted median | 12 | 8.71E-04 | 3.44E-04 | 1.13E-02 | 0.18 | rs10125995,rs1023230,rs10507084,rs12511115,rs12698822,rs142006783,rs2137605,rs28838737,rs4809902,rs76229479,rs7824549,rs9937053 |
| Sleep apnoea, including avohilmo | VI Diseases of the nervous system (G6_) | Average_Forearm | DIVW | 12 | 1.07E-03 | 2.33E-04 | 2.24E-06 | 0.18 | rs10125995,rs1023230,rs10507084,rs12511115,rs12698822,rs142006783,rs2137605,rs28838737,rs4809902,rs76229479,rs7824549,rs9937053 |
| Sleep apnoea, including avohilmo | VI Diseases of the nervous system (G6_) | Average_Forearm | GRAPPLE | 12 | 1.05E-03 | 3.09E-04 | 6.96E-04 | 0.18 | rs10125995,rs1023230,rs10507084,rs12511115,rs12698822,rs142006783,rs2137605,rs28838737,rs4809902,rs76229479,rs7824549,rs9937053 |
| Sleep apnoea, including avohilmo | VI Diseases of the nervous system (G6_) | Average_Forearm | mr_raps | 12 | 9.84E-04 | 2.37E-04 | 3.26E-05 | 0.18 | rs10125995,rs1023230,rs10507084,rs12511115,rs12698822,rs142006783,rs2137605,rs28838737,rs4809902,rs76229479,rs7824549,rs9937053 |
| Major coronary heart disease event | IX Diseases of the circulatory system (I9_) | Average_Tibia | MR Egger | 45 | -2.67E-04 | 4.18E-04 | 5.26E-01 | 0.57 | rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs11591147,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs7036656,rs72749233,rs7412,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184 |
| Major coronary heart disease event | IX Diseases of the circulatory system (I9_) | Average_Tibia | Inverse variance weighted (fixed effects) | 45 | -4.83E-04 | 1.15E-04 | 2.50E-05 | 0.57 | rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs11591147,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs7036656,rs72749233,rs7412,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184 |
| Major coronary heart disease event | IX Diseases of the circulatory system (I9_) | Average_Tibia | Inverse variance weighted (multiplicative random effects) | 45 | -4.83E-04 | 1.79E-04 | 6.84E-03 | 0.57 | rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs11591147,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs7036656,rs72749233,rs7412,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184 |
| Major coronary heart disease event | IX Diseases of the circulatory system (I9_) | Average_Tibia | Weighted mode | 45 | -2.73E-04 | 2.35E-04 | 2.51E-01 | 0.57 | rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs11591147,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs7036656,rs72749233,rs7412,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184 |
| Major coronary heart disease event | IX Diseases of the circulatory system (I9_) | Average_Tibia | Weighted median | 45 | -3.59E-04 | 1.67E-04 | 3.15E-02 | 0.57 | rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs11591147,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs7036656,rs72749233,rs7412,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184 |
| Major coronary heart disease event | IX Diseases of the circulatory system (I9_) | Average_Tibia | DIVW | 45 | -4.92E-04 | 1.17E-04 | 1.35E-05 | 0.57 | rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs11591147,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs7036656,rs72749233,rs7412,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184 |
| Major coronary heart disease event | IX Diseases of the circulatory system (I9_) | Average_Tibia | GRAPPLE | 45 | -4.62E-04 | 1.60E-04 | 4.03E-03 | 0.57 | rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs11591147,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs7036656,rs72749233,rs7412,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184 |
| Major coronary heart disease event | IX Diseases of the circulatory system (I9_) | Average_Tibia | mr_raps | 45 | -4.70E-04 | 1.19E-04 | 7.54E-05 | 0.57 | rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs11591147,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs7036656,rs72749233,rs7412,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184 |
| Major coronary heart disease event | IX Diseases of the circulatory system (I9_) | Hip_Width | MR Egger | 45 | 1.56E-04 | 2.92E-04 | 5.95E-01 | 0.10 | rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs11591147,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs7036656,rs72749233,rs7412,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184 |
| Major coronary heart disease event | IX Diseases of the circulatory system (I9_) | Hip_Width | Inverse variance weighted (fixed effects) | 45 | 6.03E-04 | 1.26E-04 | 1.69E-06 | 0.10 | rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs11591147,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs7036656,rs72749233,rs7412,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184 |
| Major coronary heart disease event | IX Diseases of the circulatory system (I9_) | Hip_Width | Inverse variance weighted (multiplicative random effects) | 45 | 6.03E-04 | 1.25E-04 | 1.42E-06 | 0.10 | rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs11591147,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs7036656,rs72749233,rs7412,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184 |
| Major coronary heart disease event | IX Diseases of the circulatory system (I9_) | Hip_Width | Weighted mode | 45 | 4.11E-04 | 3.03E-04 | 1.83E-01 | 0.10 | rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs11591147,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs7036656,rs72749233,rs7412,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184 |
| Major coronary heart disease event | IX Diseases of the circulatory system (I9_) | Hip_Width | Weighted median | 45 | 4.50E-04 | 1.83E-04 | 1.39E-02 | 0.10 | rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs11591147,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs7036656,rs72749233,rs7412,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184 |
| Major coronary heart disease event | IX Diseases of the circulatory system (I9_) | Hip_Width | DIVW | 45 | 6.14E-04 | 1.29E-04 | 9.61E-07 | 0.10 | rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs11591147,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs7036656,rs72749233,rs7412,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184 |
| Major coronary heart disease event | IX Diseases of the circulatory system (I9_) | Hip_Width | GRAPPLE | 45 | 5.68E-04 | 1.32E-04 | 1.68E-05 | 0.10 | rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs11591147,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs7036656,rs72749233,rs7412,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184 |
| Major coronary heart disease event | IX Diseases of the circulatory system (I9_) | Hip_Width | mr_raps | 45 | 5.78E-04 | 1.32E-04 | 1.22E-05 | 0.10 | rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs11591147,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs7036656,rs72749233,rs7412,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184 |
| Hard cardiovascular diseases | Cardiometabolic endpoints | Average_Tibia | MR Egger | 28 | -6.82E-04 | 6.06E-04 | 2.71E-01 | 0.88 | rs10402946,rs11238794,rs112732186,rs11591147,rs11632102,rs118039278,rs1208256,rs12705390,rs13260,rs137943060,rs147750986,rs1537371,rs17163301,rs2027939,rs2107595,rs35166119,rs3918226,rs4835377,rs629301,rs653178,rs6855875,rs6871143,rs6904438,rs7412,rs896655,rs9295128,rs9349379,rs9515203 |
| Hard cardiovascular diseases | Cardiometabolic endpoints | Average_Tibia | Inverse variance weighted (fixed effects) | 28 | -7.66E-04 | 1.60E-04 | 1.81E-06 | 0.88 | rs10402946,rs11238794,rs112732186,rs11591147,rs11632102,rs118039278,rs1208256,rs12705390,rs13260,rs137943060,rs147750986,rs1537371,rs17163301,rs2027939,rs2107595,rs35166119,rs3918226,rs4835377,rs629301,rs653178,rs6855875,rs6871143,rs6904438,rs7412,rs896655,rs9295128,rs9349379,rs9515203 |
| Hard cardiovascular diseases | Cardiometabolic endpoints | Average_Tibia | Inverse variance weighted (multiplicative random effects) | 28 | -7.66E-04 | 2.70E-04 | 4.58E-03 | 0.88 | rs10402946,rs11238794,rs112732186,rs11591147,rs11632102,rs118039278,rs1208256,rs12705390,rs13260,rs137943060,rs147750986,rs1537371,rs17163301,rs2027939,rs2107595,rs35166119,rs3918226,rs4835377,rs629301,rs653178,rs6855875,rs6871143,rs6904438,rs7412,rs896655,rs9295128,rs9349379,rs9515203 |
| Hard cardiovascular diseases | Cardiometabolic endpoints | Average_Tibia | Weighted mode | 28 | -4.58E-04 | 2.83E-04 | 1.17E-01 | 0.88 | rs10402946,rs11238794,rs112732186,rs11591147,rs11632102,rs118039278,rs1208256,rs12705390,rs13260,rs137943060,rs147750986,rs1537371,rs17163301,rs2027939,rs2107595,rs35166119,rs3918226,rs4835377,rs629301,rs653178,rs6855875,rs6871143,rs6904438,rs7412,rs896655,rs9295128,rs9349379,rs9515203 |
| Hard cardiovascular diseases | Cardiometabolic endpoints | Average_Tibia | Weighted median | 28 | -4.65E-04 | 2.46E-04 | 5.87E-02 | 0.88 | rs10402946,rs11238794,rs112732186,rs11591147,rs11632102,rs118039278,rs1208256,rs12705390,rs13260,rs137943060,rs147750986,rs1537371,rs17163301,rs2027939,rs2107595,rs35166119,rs3918226,rs4835377,rs629301,rs653178,rs6855875,rs6871143,rs6904438,rs7412,rs896655,rs9295128,rs9349379,rs9515203 |
| Hard cardiovascular diseases | Cardiometabolic endpoints | Average_Tibia | DIVW | 28 | -7.80E-04 | 1.65E-04 | 1.09E-06 | 0.88 | rs10402946,rs11238794,rs112732186,rs11591147,rs11632102,rs118039278,rs1208256,rs12705390,rs13260,rs137943060,rs147750986,rs1537371,rs17163301,rs2027939,rs2107595,rs35166119,rs3918226,rs4835377,rs629301,rs653178,rs6855875,rs6871143,rs6904438,rs7412,rs896655,rs9295128,rs9349379,rs9515203 |
| Hard cardiovascular diseases | Cardiometabolic endpoints | Average_Tibia | GRAPPLE | 28 | -8.23E-04 | 2.38E-04 | 5.39E-04 | 0.88 | rs10402946,rs11238794,rs112732186,rs11591147,rs11632102,rs118039278,rs1208256,rs12705390,rs13260,rs137943060,rs147750986,rs1537371,rs17163301,rs2027939,rs2107595,rs35166119,rs3918226,rs4835377,rs629301,rs653178,rs6855875,rs6871143,rs6904438,rs7412,rs896655,rs9295128,rs9349379,rs9515203 |
| Hard cardiovascular diseases | Cardiometabolic endpoints | Average_Tibia | mr_raps | 28 | -7.65E-04 | 1.66E-04 | 4.09E-06 | 0.88 | rs10402946,rs11238794,rs112732186,rs11591147,rs11632102,rs118039278,rs1208256,rs12705390,rs13260,rs137943060,rs147750986,rs1537371,rs17163301,rs2027939,rs2107595,rs35166119,rs3918226,rs4835377,rs629301,rs653178,rs6855875,rs6871143,rs6904438,rs7412,rs896655,rs9295128,rs9349379,rs9515203 |
| Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | Average_Tibia | MR Egger | 57 | 3.23E-04 | 4.62E-04 | 4.88E-01 | 0.44 | rs10006547,rs10429966,rs1075375,rs10779358,rs11121615,rs113280450,rs11583606,rs11589479,rs11644827,rs11680377,rs117028403,rs11766273,rs12076549,rs12203876,rs17296358,rs17451107,rs17488036,rs2066865,rs2072734,rs2074613,rs2241269,rs2250127,rs236548,rs2576381,rs3740357,rs4253417,rs4296409,rs4561320,rs4816333,rs4845948,rs56273304,rs56372651,rs6025,rs61859999,rs62164905,rs62353355,rs635634,rs6556898,rs6596004,rs6678287,rs6757275,rs6872533,rs72699119,rs72805611,rs72825107,rs72882697,rs7308872,rs7547686,rs7550758,rs7551003,rs76610873,rs76907016,rs7754245,rs7910776,rs7915861,rs79934624,rs9532432 |
| Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | Average_Tibia | Inverse variance weighted (fixed effects) | 57 | 6.45E-04 | 1.29E-04 | 6.28E-07 | 0.44 | rs10006547,rs10429966,rs1075375,rs10779358,rs11121615,rs113280450,rs11583606,rs11589479,rs11644827,rs11680377,rs117028403,rs11766273,rs12076549,rs12203876,rs17296358,rs17451107,rs17488036,rs2066865,rs2072734,rs2074613,rs2241269,rs2250127,rs236548,rs2576381,rs3740357,rs4253417,rs4296409,rs4561320,rs4816333,rs4845948,rs56273304,rs56372651,rs6025,rs61859999,rs62164905,rs62353355,rs635634,rs6556898,rs6596004,rs6678287,rs6757275,rs6872533,rs72699119,rs72805611,rs72825107,rs72882697,rs7308872,rs7547686,rs7550758,rs7551003,rs76610873,rs76907016,rs7754245,rs7910776,rs7915861,rs79934624,rs9532432 |
| Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | Average_Tibia | Inverse variance weighted (multiplicative random effects) | 57 | 6.45E-04 | 1.99E-04 | 1.19E-03 | 0.44 | rs10006547,rs10429966,rs1075375,rs10779358,rs11121615,rs113280450,rs11583606,rs11589479,rs11644827,rs11680377,rs117028403,rs11766273,rs12076549,rs12203876,rs17296358,rs17451107,rs17488036,rs2066865,rs2072734,rs2074613,rs2241269,rs2250127,rs236548,rs2576381,rs3740357,rs4253417,rs4296409,rs4561320,rs4816333,rs4845948,rs56273304,rs56372651,rs6025,rs61859999,rs62164905,rs62353355,rs635634,rs6556898,rs6596004,rs6678287,rs6757275,rs6872533,rs72699119,rs72805611,rs72825107,rs72882697,rs7308872,rs7547686,rs7550758,rs7551003,rs76610873,rs76907016,rs7754245,rs7910776,rs7915861,rs79934624,rs9532432 |
| Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | Average_Tibia | Weighted mode | 57 | 3.78E-04 | 3.36E-04 | 2.65E-01 | 0.44 | rs10006547,rs10429966,rs1075375,rs10779358,rs11121615,rs113280450,rs11583606,rs11589479,rs11644827,rs11680377,rs117028403,rs11766273,rs12076549,rs12203876,rs17296358,rs17451107,rs17488036,rs2066865,rs2072734,rs2074613,rs2241269,rs2250127,rs236548,rs2576381,rs3740357,rs4253417,rs4296409,rs4561320,rs4816333,rs4845948,rs56273304,rs56372651,rs6025,rs61859999,rs62164905,rs62353355,rs635634,rs6556898,rs6596004,rs6678287,rs6757275,rs6872533,rs72699119,rs72805611,rs72825107,rs72882697,rs7308872,rs7547686,rs7550758,rs7551003,rs76610873,rs76907016,rs7754245,rs7910776,rs7915861,rs79934624,rs9532432 |
| Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | Average_Tibia | Weighted median | 57 | 6.65E-04 | 2.29E-04 | 3.66E-03 | 0.44 | rs10006547,rs10429966,rs1075375,rs10779358,rs11121615,rs113280450,rs11583606,rs11589479,rs11644827,rs11680377,rs117028403,rs11766273,rs12076549,rs12203876,rs17296358,rs17451107,rs17488036,rs2066865,rs2072734,rs2074613,rs2241269,rs2250127,rs236548,rs2576381,rs3740357,rs4253417,rs4296409,rs4561320,rs4816333,rs4845948,rs56273304,rs56372651,rs6025,rs61859999,rs62164905,rs62353355,rs635634,rs6556898,rs6596004,rs6678287,rs6757275,rs6872533,rs72699119,rs72805611,rs72825107,rs72882697,rs7308872,rs7547686,rs7550758,rs7551003,rs76610873,rs76907016,rs7754245,rs7910776,rs7915861,rs79934624,rs9532432 |
| Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | Average_Tibia | DIVW | 57 | 6.58E-04 | 1.33E-04 | 3.54E-07 | 0.44 | rs10006547,rs10429966,rs1075375,rs10779358,rs11121615,rs113280450,rs11583606,rs11589479,rs11644827,rs11680377,rs117028403,rs11766273,rs12076549,rs12203876,rs17296358,rs17451107,rs17488036,rs2066865,rs2072734,rs2074613,rs2241269,rs2250127,rs236548,rs2576381,rs3740357,rs4253417,rs4296409,rs4561320,rs4816333,rs4845948,rs56273304,rs56372651,rs6025,rs61859999,rs62164905,rs62353355,rs635634,rs6556898,rs6596004,rs6678287,rs6757275,rs6872533,rs72699119,rs72805611,rs72825107,rs72882697,rs7308872,rs7547686,rs7550758,rs7551003,rs76610873,rs76907016,rs7754245,rs7910776,rs7915861,rs79934624,rs9532432 |
| Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | Average_Tibia | GRAPPLE | 57 | 5.86E-04 | 1.97E-04 | 2.93E-03 | 0.44 | rs10006547,rs10429966,rs1075375,rs10779358,rs11121615,rs113280450,rs11583606,rs11589479,rs11644827,rs11680377,rs117028403,rs11766273,rs12076549,rs12203876,rs17296358,rs17451107,rs17488036,rs2066865,rs2072734,rs2074613,rs2241269,rs2250127,rs236548,rs2576381,rs3740357,rs4253417,rs4296409,rs4561320,rs4816333,rs4845948,rs56273304,rs56372651,rs6025,rs61859999,rs62164905,rs62353355,rs635634,rs6556898,rs6596004,rs6678287,rs6757275,rs6872533,rs72699119,rs72805611,rs72825107,rs72882697,rs7308872,rs7547686,rs7550758,rs7551003,rs76610873,rs76907016,rs7754245,rs7910776,rs7915861,rs79934624,rs9532432 |
| Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | IX Diseases of the circulatory system (I9_) | Average_Tibia | mr_raps | 57 | 6.74E-04 | 1.34E-04 | 5.03E-07 | 0.44 | rs10006547,rs10429966,rs1075375,rs10779358,rs11121615,rs113280450,rs11583606,rs11589479,rs11644827,rs11680377,rs117028403,rs11766273,rs12076549,rs12203876,rs17296358,rs17451107,rs17488036,rs2066865,rs2072734,rs2074613,rs2241269,rs2250127,rs236548,rs2576381,rs3740357,rs4253417,rs4296409,rs4561320,rs4816333,rs4845948,rs56273304,rs56372651,rs6025,rs61859999,rs62164905,rs62353355,rs635634,rs6556898,rs6596004,rs6678287,rs6757275,rs6872533,rs72699119,rs72805611,rs72825107,rs72882697,rs7308872,rs7547686,rs7550758,rs7551003,rs76610873,rs76907016,rs7754245,rs7910776,rs7915861,rs79934624,rs9532432 |
| Ischemic heart diseases | IX Diseases of the circulatory system (I9_) | Average_Tibia | MR Egger | 48 | -3.36E-04 | 3.66E-04 | 3.64E-01 | 0.40 | rs10431974,rs1044506,rs10455872,rs10793514,rs10811665,rs10945646,rs10965106,rs11591147,rs11619038,rs11698996,rs117733303,rs1199337,rs12438645,rs12945851,rs13134800,rs137943060,rs1537371,rs16942194,rs17489268,rs1763943,rs1835346,rs2000660,rs207180,rs2107595,rs2128739,rs2188127,rs2392929,rs28533705,rs28673728,rs3741298,rs3918226,rs4350997,rs553741,rs59877521,rs629301,rs653178,rs6892439,rs72664324,rs72794188,rs72938315,rs73181271,rs73855809,rs7412,rs7668383,rs78536205,rs8034587,rs9349379,rs9515203 |
| Ischemic heart diseases | IX Diseases of the circulatory system (I9_) | Average_Tibia | Inverse variance weighted (fixed effects) | 48 | -6.13E-04 | 1.24E-04 | 7.68E-07 | 0.40 | rs10431974,rs1044506,rs10455872,rs10793514,rs10811665,rs10945646,rs10965106,rs11591147,rs11619038,rs11698996,rs117733303,rs1199337,rs12438645,rs12945851,rs13134800,rs137943060,rs1537371,rs16942194,rs17489268,rs1763943,rs1835346,rs2000660,rs207180,rs2107595,rs2128739,rs2188127,rs2392929,rs28533705,rs28673728,rs3741298,rs3918226,rs4350997,rs553741,rs59877521,rs629301,rs653178,rs6892439,rs72664324,rs72794188,rs72938315,rs73181271,rs73855809,rs7412,rs7668383,rs78536205,rs8034587,rs9349379,rs9515203 |
| Ischemic heart diseases | IX Diseases of the circulatory system (I9_) | Average_Tibia | Inverse variance weighted (multiplicative random effects) | 48 | -6.13E-04 | 1.64E-04 | 1.92E-04 | 0.40 | rs10431974,rs1044506,rs10455872,rs10793514,rs10811665,rs10945646,rs10965106,rs11591147,rs11619038,rs11698996,rs117733303,rs1199337,rs12438645,rs12945851,rs13134800,rs137943060,rs1537371,rs16942194,rs17489268,rs1763943,rs1835346,rs2000660,rs207180,rs2107595,rs2128739,rs2188127,rs2392929,rs28533705,rs28673728,rs3741298,rs3918226,rs4350997,rs553741,rs59877521,rs629301,rs653178,rs6892439,rs72664324,rs72794188,rs72938315,rs73181271,rs73855809,rs7412,rs7668383,rs78536205,rs8034587,rs9349379,rs9515203 |
| Ischemic heart diseases | IX Diseases of the circulatory system (I9_) | Average_Tibia | Weighted mode | 48 | -3.66E-04 | 2.32E-04 | 1.22E-01 | 0.40 | rs10431974,rs1044506,rs10455872,rs10793514,rs10811665,rs10945646,rs10965106,rs11591147,rs11619038,rs11698996,rs117733303,rs1199337,rs12438645,rs12945851,rs13134800,rs137943060,rs1537371,rs16942194,rs17489268,rs1763943,rs1835346,rs2000660,rs207180,rs2107595,rs2128739,rs2188127,rs2392929,rs28533705,rs28673728,rs3741298,rs3918226,rs4350997,rs553741,rs59877521,rs629301,rs653178,rs6892439,rs72664324,rs72794188,rs72938315,rs73181271,rs73855809,rs7412,rs7668383,rs78536205,rs8034587,rs9349379,rs9515203 |
| Ischemic heart diseases | IX Diseases of the circulatory system (I9_) | Average_Tibia | Weighted median | 48 | -4.37E-04 | 1.99E-04 | 2.84E-02 | 0.40 | rs10431974,rs1044506,rs10455872,rs10793514,rs10811665,rs10945646,rs10965106,rs11591147,rs11619038,rs11698996,rs117733303,rs1199337,rs12438645,rs12945851,rs13134800,rs137943060,rs1537371,rs16942194,rs17489268,rs1763943,rs1835346,rs2000660,rs207180,rs2107595,rs2128739,rs2188127,rs2392929,rs28533705,rs28673728,rs3741298,rs3918226,rs4350997,rs553741,rs59877521,rs629301,rs653178,rs6892439,rs72664324,rs72794188,rs72938315,rs73181271,rs73855809,rs7412,rs7668383,rs78536205,rs8034587,rs9349379,rs9515203 |
| Ischemic heart diseases | IX Diseases of the circulatory system (I9_) | Average_Tibia | DIVW | 48 | -6.24E-04 | 1.27E-04 | 4.36E-07 | 0.40 | rs10431974,rs1044506,rs10455872,rs10793514,rs10811665,rs10945646,rs10965106,rs11591147,rs11619038,rs11698996,rs117733303,rs1199337,rs12438645,rs12945851,rs13134800,rs137943060,rs1537371,rs16942194,rs17489268,rs1763943,rs1835346,rs2000660,rs207180,rs2107595,rs2128739,rs2188127,rs2392929,rs28533705,rs28673728,rs3741298,rs3918226,rs4350997,rs553741,rs59877521,rs629301,rs653178,rs6892439,rs72664324,rs72794188,rs72938315,rs73181271,rs73855809,rs7412,rs7668383,rs78536205,rs8034587,rs9349379,rs9515203 |
| Ischemic heart diseases | IX Diseases of the circulatory system (I9_) | Average_Tibia | GRAPPLE | 48 | -5.51E-04 | 1.54E-04 | 3.35E-04 | 0.40 | rs10431974,rs1044506,rs10455872,rs10793514,rs10811665,rs10945646,rs10965106,rs11591147,rs11619038,rs11698996,rs117733303,rs1199337,rs12438645,rs12945851,rs13134800,rs137943060,rs1537371,rs16942194,rs17489268,rs1763943,rs1835346,rs2000660,rs207180,rs2107595,rs2128739,rs2188127,rs2392929,rs28533705,rs28673728,rs3741298,rs3918226,rs4350997,rs553741,rs59877521,rs629301,rs653178,rs6892439,rs72664324,rs72794188,rs72938315,rs73181271,rs73855809,rs7412,rs7668383,rs78536205,rs8034587,rs9349379,rs9515203 |
| Ischemic heart diseases | IX Diseases of the circulatory system (I9_) | Average_Tibia | mr_raps | 48 | -5.66E-04 | 1.29E-04 | 1.15E-05 | 0.40 | rs10431974,rs1044506,rs10455872,rs10793514,rs10811665,rs10945646,rs10965106,rs11591147,rs11619038,rs11698996,rs117733303,rs1199337,rs12438645,rs12945851,rs13134800,rs137943060,rs1537371,rs16942194,rs17489268,rs1763943,rs1835346,rs2000660,rs207180,rs2107595,rs2128739,rs2188127,rs2392929,rs28533705,rs28673728,rs3741298,rs3918226,rs4350997,rs553741,rs59877521,rs629301,rs653178,rs6892439,rs72664324,rs72794188,rs72938315,rs73181271,rs73855809,rs7412,rs7668383,rs78536205,rs8034587,rs9349379,rs9515203 |
| Ischemic heart diseases | IX Diseases of the circulatory system (I9_) | Torso_Length | MR Egger | 48 | 3.95E-04 | 5.03E-04 | 4.36E-01 | 0.20 | rs10431974,rs1044506,rs10455872,rs10793514,rs10811665,rs10945646,rs10965106,rs11591147,rs11619038,rs11698996,rs117733303,rs1199337,rs12438645,rs12945851,rs13134800,rs137943060,rs1537371,rs16942194,rs17489268,rs1763943,rs1835346,rs2000660,rs207180,rs2107595,rs2128739,rs2188127,rs2392929,rs28533705,rs28673728,rs3741298,rs3918226,rs4350997,rs553741,rs59877521,rs629301,rs653178,rs6892439,rs72664324,rs72794188,rs72938315,rs73181271,rs73855809,rs7412,rs7668383,rs78536205,rs8034587,rs9349379,rs9515203 |
| Ischemic heart diseases | IX Diseases of the circulatory system (I9_) | Torso_Length | Inverse variance weighted (fixed effects) | 48 | 9.84E-04 | 2.27E-04 | 1.41E-05 | 0.20 | rs10431974,rs1044506,rs10455872,rs10793514,rs10811665,rs10945646,rs10965106,rs11591147,rs11619038,rs11698996,rs117733303,rs1199337,rs12438645,rs12945851,rs13134800,rs137943060,rs1537371,rs16942194,rs17489268,rs1763943,rs1835346,rs2000660,rs207180,rs2107595,rs2128739,rs2188127,rs2392929,rs28533705,rs28673728,rs3741298,rs3918226,rs4350997,rs553741,rs59877521,rs629301,rs653178,rs6892439,rs72664324,rs72794188,rs72938315,rs73181271,rs73855809,rs7412,rs7668383,rs78536205,rs8034587,rs9349379,rs9515203 |
| Ischemic heart diseases | IX Diseases of the circulatory system (I9_) | Torso_Length | Inverse variance weighted (multiplicative random effects) | 48 | 9.84E-04 | 1.97E-04 | 5.91E-07 | 0.20 | rs10431974,rs1044506,rs10455872,rs10793514,rs10811665,rs10945646,rs10965106,rs11591147,rs11619038,rs11698996,rs117733303,rs1199337,rs12438645,rs12945851,rs13134800,rs137943060,rs1537371,rs16942194,rs17489268,rs1763943,rs1835346,rs2000660,rs207180,rs2107595,rs2128739,rs2188127,rs2392929,rs28533705,rs28673728,rs3741298,rs3918226,rs4350997,rs553741,rs59877521,rs629301,rs653178,rs6892439,rs72664324,rs72794188,rs72938315,rs73181271,rs73855809,rs7412,rs7668383,rs78536205,rs8034587,rs9349379,rs9515203 |
| Ischemic heart diseases | IX Diseases of the circulatory system (I9_) | Torso_Length | Weighted mode | 48 | 5.59E-04 | 4.69E-04 | 2.39E-01 | 0.20 | rs10431974,rs1044506,rs10455872,rs10793514,rs10811665,rs10945646,rs10965106,rs11591147,rs11619038,rs11698996,rs117733303,rs1199337,rs12438645,rs12945851,rs13134800,rs137943060,rs1537371,rs16942194,rs17489268,rs1763943,rs1835346,rs2000660,rs207180,rs2107595,rs2128739,rs2188127,rs2392929,rs28533705,rs28673728,rs3741298,rs3918226,rs4350997,rs553741,rs59877521,rs629301,rs653178,rs6892439,rs72664324,rs72794188,rs72938315,rs73181271,rs73855809,rs7412,rs7668383,rs78536205,rs8034587,rs9349379,rs9515203 |
| Ischemic heart diseases | IX Diseases of the circulatory system (I9_) | Torso_Length | Weighted median | 48 | 6.89E-04 | 3.38E-04 | 4.16E-02 | 0.20 | rs10431974,rs1044506,rs10455872,rs10793514,rs10811665,rs10945646,rs10965106,rs11591147,rs11619038,rs11698996,rs117733303,rs1199337,rs12438645,rs12945851,rs13134800,rs137943060,rs1537371,rs16942194,rs17489268,rs1763943,rs1835346,rs2000660,rs207180,rs2107595,rs2128739,rs2188127,rs2392929,rs28533705,rs28673728,rs3741298,rs3918226,rs4350997,rs553741,rs59877521,rs629301,rs653178,rs6892439,rs72664324,rs72794188,rs72938315,rs73181271,rs73855809,rs7412,rs7668383,rs78536205,rs8034587,rs9349379,rs9515203 |
| Ischemic heart diseases | IX Diseases of the circulatory system (I9_) | Torso_Length | DIVW | 48 | 1.00E-03 | 2.31E-04 | 7.60E-06 | 0.20 | rs10431974,rs1044506,rs10455872,rs10793514,rs10811665,rs10945646,rs10965106,rs11591147,rs11619038,rs11698996,rs117733303,rs1199337,rs12438645,rs12945851,rs13134800,rs137943060,rs1537371,rs16942194,rs17489268,rs1763943,rs1835346,rs2000660,rs207180,rs2107595,rs2128739,rs2188127,rs2392929,rs28533705,rs28673728,rs3741298,rs3918226,rs4350997,rs553741,rs59877521,rs629301,rs653178,rs6892439,rs72664324,rs72794188,rs72938315,rs73181271,rs73855809,rs7412,rs7668383,rs78536205,rs8034587,rs9349379,rs9515203 |
| Ischemic heart diseases | IX Diseases of the circulatory system (I9_) | Torso_Length | GRAPPLE | 48 | 1.04E-03 | 2.37E-04 | 1.12E-05 | 0.20 | rs10431974,rs1044506,rs10455872,rs10793514,rs10811665,rs10945646,rs10965106,rs11591147,rs11619038,rs11698996,rs117733303,rs1199337,rs12438645,rs12945851,rs13134800,rs137943060,rs1537371,rs16942194,rs17489268,rs1763943,rs1835346,rs2000660,rs207180,rs2107595,rs2128739,rs2188127,rs2392929,rs28533705,rs28673728,rs3741298,rs3918226,rs4350997,rs553741,rs59877521,rs629301,rs653178,rs6892439,rs72664324,rs72794188,rs72938315,rs73181271,rs73855809,rs7412,rs7668383,rs78536205,rs8034587,rs9349379,rs9515203 |
| Ischemic heart diseases | IX Diseases of the circulatory system (I9_) | Torso_Length | mr_raps | 48 | 1.05E-03 | 2.38E-04 | 1.02E-05 | 0.20 | rs10431974,rs1044506,rs10455872,rs10793514,rs10811665,rs10945646,rs10965106,rs11591147,rs11619038,rs11698996,rs117733303,rs1199337,rs12438645,rs12945851,rs13134800,rs137943060,rs1537371,rs16942194,rs17489268,rs1763943,rs1835346,rs2000660,rs207180,rs2107595,rs2128739,rs2188127,rs2392929,rs28533705,rs28673728,rs3741298,rs3918226,rs4350997,rs553741,rs59877521,rs629301,rs653178,rs6892439,rs72664324,rs72794188,rs72938315,rs73181271,rs73855809,rs7412,rs7668383,rs78536205,rs8034587,rs9349379,rs9515203 |
| Gonarthrosis [arthrosis of knee](FG) | Rheuma endpoints | Average_Tibia | MR Egger | 28 | -1.53E-03 | 2.28E-03 | 5.08E-01 | 0.29 | rs10131337,rs10408721,rs10817111,rs12684080,rs12706012,rs12985258,rs143383,rs1480474,rs1558902,rs1707304,rs1887508,rs2075650,rs2247341,rs2716214,rs28514678,rs2902345,rs374892365,rs4606747,rs4759409,rs6066105,rs62070648,rs6945340,rs7091815,rs7174015,rs7240629,rs727479,rs7279363,rs7977132 |
| Gonarthrosis [arthrosis of knee](FG) | Rheuma endpoints | Average_Tibia | Inverse variance weighted (fixed effects) | 28 | 8.98E-04 | 1.88E-04 | 1.69E-06 | 0.29 | rs10131337,rs10408721,rs10817111,rs12684080,rs12706012,rs12985258,rs143383,rs1480474,rs1558902,rs1707304,rs1887508,rs2075650,rs2247341,rs2716214,rs28514678,rs2902345,rs374892365,rs4606747,rs4759409,rs6066105,rs62070648,rs6945340,rs7091815,rs7174015,rs7240629,rs727479,rs7279363,rs7977132 |
| Gonarthrosis [arthrosis of knee](FG) | Rheuma endpoints | Average_Tibia | Inverse variance weighted (multiplicative random effects) | 28 | 8.98E-04 | 3.68E-04 | 1.47E-02 | 0.29 | rs10131337,rs10408721,rs10817111,rs12684080,rs12706012,rs12985258,rs143383,rs1480474,rs1558902,rs1707304,rs1887508,rs2075650,rs2247341,rs2716214,rs28514678,rs2902345,rs374892365,rs4606747,rs4759409,rs6066105,rs62070648,rs6945340,rs7091815,rs7174015,rs7240629,rs727479,rs7279363,rs7977132 |
| Gonarthrosis [arthrosis of knee](FG) | Rheuma endpoints | Average_Tibia | Weighted mode | 28 | 5.27E-04 | 5.82E-04 | 3.72E-01 | 0.29 | rs10131337,rs10408721,rs10817111,rs12684080,rs12706012,rs12985258,rs143383,rs1480474,rs1558902,rs1707304,rs1887508,rs2075650,rs2247341,rs2716214,rs28514678,rs2902345,rs374892365,rs4606747,rs4759409,rs6066105,rs62070648,rs6945340,rs7091815,rs7174015,rs7240629,rs727479,rs7279363,rs7977132 |
| Gonarthrosis [arthrosis of knee](FG) | Rheuma endpoints | Average_Tibia | Weighted median | 28 | 5.95E-04 | 3.19E-04 | 6.17E-02 | 0.29 | rs10131337,rs10408721,rs10817111,rs12684080,rs12706012,rs12985258,rs143383,rs1480474,rs1558902,rs1707304,rs1887508,rs2075650,rs2247341,rs2716214,rs28514678,rs2902345,rs374892365,rs4606747,rs4759409,rs6066105,rs62070648,rs6945340,rs7091815,rs7174015,rs7240629,rs727479,rs7279363,rs7977132 |
| Gonarthrosis [arthrosis of knee](FG) | Rheuma endpoints | Average_Tibia | DIVW | 28 | 9.21E-04 | 1.95E-04 | 1.10E-06 | 0.29 | rs10131337,rs10408721,rs10817111,rs12684080,rs12706012,rs12985258,rs143383,rs1480474,rs1558902,rs1707304,rs1887508,rs2075650,rs2247341,rs2716214,rs28514678,rs2902345,rs374892365,rs4606747,rs4759409,rs6066105,rs62070648,rs6945340,rs7091815,rs7174015,rs7240629,rs727479,rs7279363,rs7977132 |
| Gonarthrosis [arthrosis of knee](FG) | Rheuma endpoints | Average_Tibia | GRAPPLE | 28 | 8.31E-04 | 3.76E-04 | 2.68E-02 | 0.29 | rs10131337,rs10408721,rs10817111,rs12684080,rs12706012,rs12985258,rs143383,rs1480474,rs1558902,rs1707304,rs1887508,rs2075650,rs2247341,rs2716214,rs28514678,rs2902345,rs374892365,rs4606747,rs4759409,rs6066105,rs62070648,rs6945340,rs7091815,rs7174015,rs7240629,rs727479,rs7279363,rs7977132 |
| Gonarthrosis [arthrosis of knee](FG) | Rheuma endpoints | Average_Tibia | mr_raps | 28 | 8.73E-04 | 1.92E-04 | 5.62E-06 | 0.29 | rs10131337,rs10408721,rs10817111,rs12684080,rs12706012,rs12985258,rs143383,rs1480474,rs1558902,rs1707304,rs1887508,rs2075650,rs2247341,rs2716214,rs28514678,rs2902345,rs374892365,rs4606747,rs4759409,rs6066105,rs62070648,rs6945340,rs7091815,rs7174015,rs7240629,rs727479,rs7279363,rs7977132 |
| Hyperplasia of prostate | XIV Diseases of the genitourinary system (N14_) | Average_Humerus | MR Egger | 27 | -9.11E-06 | 5.57E-04 | 9.87E-01 | 0.21 | rs10068678,rs10478061,rs10788167,rs13276836,rs145464945,rs147647111,rs17101982,rs17632542,rs1991643,rs255261,rs2853677,rs2871960,rs3130623,rs3213180,rs35908689,rs366991,rs370348,rs4869246,rs61185428,rs671044,rs6983267,rs73223878,rs73686991,rs7905955,rs8097576,rs987086,rs9901746 |
| Hyperplasia of prostate | XIV Diseases of the genitourinary system (N14_) | Average_Humerus | Inverse variance weighted (fixed effects) | 27 | 6.86E-04 | 1.27E-04 | 7.00E-08 | 0.21 | rs10068678,rs10478061,rs10788167,rs13276836,rs145464945,rs147647111,rs17101982,rs17632542,rs1991643,rs255261,rs2853677,rs2871960,rs3130623,rs3213180,rs35908689,rs366991,rs370348,rs4869246,rs61185428,rs671044,rs6983267,rs73223878,rs73686991,rs7905955,rs8097576,rs987086,rs9901746 |
| Hyperplasia of prostate | XIV Diseases of the genitourinary system (N14_) | Average_Humerus | Inverse variance weighted (multiplicative random effects) | 27 | 6.86E-04 | 1.60E-04 | 1.93E-05 | 0.21 | rs10068678,rs10478061,rs10788167,rs13276836,rs145464945,rs147647111,rs17101982,rs17632542,rs1991643,rs255261,rs2853677,rs2871960,rs3130623,rs3213180,rs35908689,rs366991,rs370348,rs4869246,rs61185428,rs671044,rs6983267,rs73223878,rs73686991,rs7905955,rs8097576,rs987086,rs9901746 |
| Hyperplasia of prostate | XIV Diseases of the genitourinary system (N14_) | Average_Humerus | Weighted mode | 27 | 1.55E-04 | 3.41E-04 | 6.54E-01 | 0.21 | rs10068678,rs10478061,rs10788167,rs13276836,rs145464945,rs147647111,rs17101982,rs17632542,rs1991643,rs255261,rs2853677,rs2871960,rs3130623,rs3213180,rs35908689,rs366991,rs370348,rs4869246,rs61185428,rs671044,rs6983267,rs73223878,rs73686991,rs7905955,rs8097576,rs987086,rs9901746 |
| Hyperplasia of prostate | XIV Diseases of the genitourinary system (N14_) | Average_Humerus | Weighted median | 27 | 6.63E-04 | 1.86E-04 | 3.63E-04 | 0.21 | rs10068678,rs10478061,rs10788167,rs13276836,rs145464945,rs147647111,rs17101982,rs17632542,rs1991643,rs255261,rs2853677,rs2871960,rs3130623,rs3213180,rs35908689,rs366991,rs370348,rs4869246,rs61185428,rs671044,rs6983267,rs73223878,rs73686991,rs7905955,rs8097576,rs987086,rs9901746 |
| Hyperplasia of prostate | XIV Diseases of the genitourinary system (N14_) | Average_Humerus | DIVW | 27 | 7.02E-04 | 1.32E-04 | 5.29E-08 | 0.21 | rs10068678,rs10478061,rs10788167,rs13276836,rs145464945,rs147647111,rs17101982,rs17632542,rs1991643,rs255261,rs2853677,rs2871960,rs3130623,rs3213180,rs35908689,rs366991,rs370348,rs4869246,rs61185428,rs671044,rs6983267,rs73223878,rs73686991,rs7905955,rs8097576,rs987086,rs9901746 |
| Hyperplasia of prostate | XIV Diseases of the genitourinary system (N14_) | Average_Humerus | GRAPPLE | 27 | 6.32E-04 | 1.70E-04 | 2.01E-04 | 0.21 | rs10068678,rs10478061,rs10788167,rs13276836,rs145464945,rs147647111,rs17101982,rs17632542,rs1991643,rs255261,rs2853677,rs2871960,rs3130623,rs3213180,rs35908689,rs366991,rs370348,rs4869246,rs61185428,rs671044,rs6983267,rs73223878,rs73686991,rs7905955,rs8097576,rs987086,rs9901746 |
| Hyperplasia of prostate | XIV Diseases of the genitourinary system (N14_) | Average_Humerus | mr_raps | 27 | 6.10E-04 | 1.33E-04 | 4.70E-06 | 0.21 | rs10068678,rs10478061,rs10788167,rs13276836,rs145464945,rs147647111,rs17101982,rs17632542,rs1991643,rs255261,rs2853677,rs2871960,rs3130623,rs3213180,rs35908689,rs366991,rs370348,rs4869246,rs61185428,rs671044,rs6983267,rs73223878,rs73686991,rs7905955,rs8097576,rs987086,rs9901746 |