Heart & clinical endpoints

About

At the Bonferroni significance level (P < 6.85e-6, multiple testing adjustment for both directions) , MR suggested 138 significant genetic causal effects (27 “heart to clinical outcomes” and 111 “clinical outcomes to heart”).

Overview of Heart MR results

Heart MR results

id.exposure	id.outcome	out.category	method	nsnp	b	se	pval	MR-Egger intercept	snps
ascending aorta maximum area	Aortic aneurysm	IX Diseases of the circulatory system (I9_)	MR Egger	47	0.55	0.23	1.92E-02	0.33	rs10059884,rs1108450,rs11235460,rs11250162,rs112858262,rs12755444,rs12771055,rs1441358,rs150260620,rs1570350,rs1583081,rs1630736,rs16965180,rs178406,rs1862771,rs2255266,rs2429917,rs2509133,rs2686630,rs2871651,rs335196,rs34557926,rs34968301,rs4148674,rs4791494,rs4905134,rs55745974,rs57774511,rs60155001,rs6040055,rs62053262,rs62270945,rs627634,rs67846163,rs6809328,rs6974735,rs7009229,rs72931764,rs73136870,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs934012
ascending aorta maximum area	Aortic aneurysm	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (fixed effects)	47	0.77	0.05	1.45E-53	0.33	rs10059884,rs1108450,rs11235460,rs11250162,rs112858262,rs12755444,rs12771055,rs1441358,rs150260620,rs1570350,rs1583081,rs1630736,rs16965180,rs178406,rs1862771,rs2255266,rs2429917,rs2509133,rs2686630,rs2871651,rs335196,rs34557926,rs34968301,rs4148674,rs4791494,rs4905134,rs55745974,rs57774511,rs60155001,rs6040055,rs62053262,rs62270945,rs627634,rs67846163,rs6809328,rs6974735,rs7009229,rs72931764,rs73136870,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs934012
ascending aorta maximum area	Aortic aneurysm	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (multiplicative random effects)	47	0.77	0.08	9.71E-22	0.33	rs10059884,rs1108450,rs11235460,rs11250162,rs112858262,rs12755444,rs12771055,rs1441358,rs150260620,rs1570350,rs1583081,rs1630736,rs16965180,rs178406,rs1862771,rs2255266,rs2429917,rs2509133,rs2686630,rs2871651,rs335196,rs34557926,rs34968301,rs4148674,rs4791494,rs4905134,rs55745974,rs57774511,rs60155001,rs6040055,rs62053262,rs62270945,rs627634,rs67846163,rs6809328,rs6974735,rs7009229,rs72931764,rs73136870,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs934012
ascending aorta maximum area	Aortic aneurysm	IX Diseases of the circulatory system (I9_)	Weighted mode	47	0.71	0.17	8.68E-05	0.33	rs10059884,rs1108450,rs11235460,rs11250162,rs112858262,rs12755444,rs12771055,rs1441358,rs150260620,rs1570350,rs1583081,rs1630736,rs16965180,rs178406,rs1862771,rs2255266,rs2429917,rs2509133,rs2686630,rs2871651,rs335196,rs34557926,rs34968301,rs4148674,rs4791494,rs4905134,rs55745974,rs57774511,rs60155001,rs6040055,rs62053262,rs62270945,rs627634,rs67846163,rs6809328,rs6974735,rs7009229,rs72931764,rs73136870,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs934012
ascending aorta maximum area	Aortic aneurysm	IX Diseases of the circulatory system (I9_)	Weighted median	47	0.71	0.09	8.76E-16	0.33	rs10059884,rs1108450,rs11235460,rs11250162,rs112858262,rs12755444,rs12771055,rs1441358,rs150260620,rs1570350,rs1583081,rs1630736,rs16965180,rs178406,rs1862771,rs2255266,rs2429917,rs2509133,rs2686630,rs2871651,rs335196,rs34557926,rs34968301,rs4148674,rs4791494,rs4905134,rs55745974,rs57774511,rs60155001,rs6040055,rs62053262,rs62270945,rs627634,rs67846163,rs6809328,rs6974735,rs7009229,rs72931764,rs73136870,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs934012
ascending aorta maximum area	Aortic aneurysm	IX Diseases of the circulatory system (I9_)	DIVW	47	0.78	0.05	0.00E+00	0.33	rs10059884,rs1108450,rs11235460,rs11250162,rs112858262,rs12755444,rs12771055,rs1441358,rs150260620,rs1570350,rs1583081,rs1630736,rs16965180,rs178406,rs1862771,rs2255266,rs2429917,rs2509133,rs2686630,rs2871651,rs335196,rs34557926,rs34968301,rs4148674,rs4791494,rs4905134,rs55745974,rs57774511,rs60155001,rs6040055,rs62053262,rs62270945,rs627634,rs67846163,rs6809328,rs6974735,rs7009229,rs72931764,rs73136870,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs934012
ascending aorta maximum area	Aortic aneurysm	IX Diseases of the circulatory system (I9_)	GRAPPLE	47	0.77	0.08	6.96E-20	0.33	rs10059884,rs1108450,rs11235460,rs11250162,rs112858262,rs12755444,rs12771055,rs1441358,rs150260620,rs1570350,rs1583081,rs1630736,rs16965180,rs178406,rs1862771,rs2255266,rs2429917,rs2509133,rs2686630,rs2871651,rs335196,rs34557926,rs34968301,rs4148674,rs4791494,rs4905134,rs55745974,rs57774511,rs60155001,rs6040055,rs62053262,rs62270945,rs627634,rs67846163,rs6809328,rs6974735,rs7009229,rs72931764,rs73136870,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs934012
ascending aorta maximum area	Aortic aneurysm	IX Diseases of the circulatory system (I9_)	mr_raps	47	0.80	0.05	0.00E+00	0.33	rs10059884,rs1108450,rs11235460,rs11250162,rs112858262,rs12755444,rs12771055,rs1441358,rs150260620,rs1570350,rs1583081,rs1630736,rs16965180,rs178406,rs1862771,rs2255266,rs2429917,rs2509133,rs2686630,rs2871651,rs335196,rs34557926,rs34968301,rs4148674,rs4791494,rs4905134,rs55745974,rs57774511,rs60155001,rs6040055,rs62053262,rs62270945,rs627634,rs67846163,rs6809328,rs6974735,rs7009229,rs72931764,rs73136870,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs934012
ascending aorta maximum area	Diseases of arteries, arterioles and capillaries	IX Diseases of the circulatory system (I9_)	MR Egger	47	0.20	0.13	1.14E-01	0.97	rs10059884,rs1108450,rs11235460,rs11250162,rs112858262,rs12755444,rs12771055,rs1441358,rs150260620,rs1570350,rs1583081,rs1630736,rs16965180,rs178406,rs1862771,rs2255266,rs2429917,rs2509133,rs2686630,rs2871651,rs335196,rs34557926,rs34968301,rs4148674,rs4791494,rs4905134,rs55745974,rs57774511,rs60155001,rs6040055,rs62053262,rs62270945,rs627634,rs67846163,rs6809328,rs6974735,rs7009229,rs72931764,rs73136870,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs934012
ascending aorta maximum area	Diseases of arteries, arterioles and capillaries	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (fixed effects)	47	0.21	0.03	2.01E-13	0.97	rs10059884,rs1108450,rs11235460,rs11250162,rs112858262,rs12755444,rs12771055,rs1441358,rs150260620,rs1570350,rs1583081,rs1630736,rs16965180,rs178406,rs1862771,rs2255266,rs2429917,rs2509133,rs2686630,rs2871651,rs335196,rs34557926,rs34968301,rs4148674,rs4791494,rs4905134,rs55745974,rs57774511,rs60155001,rs6040055,rs62053262,rs62270945,rs627634,rs67846163,rs6809328,rs6974735,rs7009229,rs72931764,rs73136870,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs934012
ascending aorta maximum area	Diseases of arteries, arterioles and capillaries	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (multiplicative random effects)	47	0.21	0.04	2.11E-06	0.97	rs10059884,rs1108450,rs11235460,rs11250162,rs112858262,rs12755444,rs12771055,rs1441358,rs150260620,rs1570350,rs1583081,rs1630736,rs16965180,rs178406,rs1862771,rs2255266,rs2429917,rs2509133,rs2686630,rs2871651,rs335196,rs34557926,rs34968301,rs4148674,rs4791494,rs4905134,rs55745974,rs57774511,rs60155001,rs6040055,rs62053262,rs62270945,rs627634,rs67846163,rs6809328,rs6974735,rs7009229,rs72931764,rs73136870,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs934012
ascending aorta maximum area	Diseases of arteries, arterioles and capillaries	IX Diseases of the circulatory system (I9_)	Weighted mode	47	0.22	0.07	3.18E-03	0.97	rs10059884,rs1108450,rs11235460,rs11250162,rs112858262,rs12755444,rs12771055,rs1441358,rs150260620,rs1570350,rs1583081,rs1630736,rs16965180,rs178406,rs1862771,rs2255266,rs2429917,rs2509133,rs2686630,rs2871651,rs335196,rs34557926,rs34968301,rs4148674,rs4791494,rs4905134,rs55745974,rs57774511,rs60155001,rs6040055,rs62053262,rs62270945,rs627634,rs67846163,rs6809328,rs6974735,rs7009229,rs72931764,rs73136870,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs934012
ascending aorta maximum area	Diseases of arteries, arterioles and capillaries	IX Diseases of the circulatory system (I9_)	Weighted median	47	0.22	0.05	2.17E-06	0.97	rs10059884,rs1108450,rs11235460,rs11250162,rs112858262,rs12755444,rs12771055,rs1441358,rs150260620,rs1570350,rs1583081,rs1630736,rs16965180,rs178406,rs1862771,rs2255266,rs2429917,rs2509133,rs2686630,rs2871651,rs335196,rs34557926,rs34968301,rs4148674,rs4791494,rs4905134,rs55745974,rs57774511,rs60155001,rs6040055,rs62053262,rs62270945,rs627634,rs67846163,rs6809328,rs6974735,rs7009229,rs72931764,rs73136870,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs934012
ascending aorta maximum area	Diseases of arteries, arterioles and capillaries	IX Diseases of the circulatory system (I9_)	DIVW	47	0.21	0.03	1.80E-13	0.97	rs10059884,rs1108450,rs11235460,rs11250162,rs112858262,rs12755444,rs12771055,rs1441358,rs150260620,rs1570350,rs1583081,rs1630736,rs16965180,rs178406,rs1862771,rs2255266,rs2429917,rs2509133,rs2686630,rs2871651,rs335196,rs34557926,rs34968301,rs4148674,rs4791494,rs4905134,rs55745974,rs57774511,rs60155001,rs6040055,rs62053262,rs62270945,rs627634,rs67846163,rs6809328,rs6974735,rs7009229,rs72931764,rs73136870,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs934012
ascending aorta maximum area	Diseases of arteries, arterioles and capillaries	IX Diseases of the circulatory system (I9_)	GRAPPLE	47	0.22	0.04	5.21E-07	0.97	rs10059884,rs1108450,rs11235460,rs11250162,rs112858262,rs12755444,rs12771055,rs1441358,rs150260620,rs1570350,rs1583081,rs1630736,rs16965180,rs178406,rs1862771,rs2255266,rs2429917,rs2509133,rs2686630,rs2871651,rs335196,rs34557926,rs34968301,rs4148674,rs4791494,rs4905134,rs55745974,rs57774511,rs60155001,rs6040055,rs62053262,rs62270945,rs627634,rs67846163,rs6809328,rs6974735,rs7009229,rs72931764,rs73136870,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs934012
ascending aorta maximum area	Diseases of arteries, arterioles and capillaries	IX Diseases of the circulatory system (I9_)	mr_raps	47	0.21	0.03	3.04E-13	0.97	rs10059884,rs1108450,rs11235460,rs11250162,rs112858262,rs12755444,rs12771055,rs1441358,rs150260620,rs1570350,rs1583081,rs1630736,rs16965180,rs178406,rs1862771,rs2255266,rs2429917,rs2509133,rs2686630,rs2871651,rs335196,rs34557926,rs34968301,rs4148674,rs4791494,rs4905134,rs55745974,rs57774511,rs60155001,rs6040055,rs62053262,rs62270945,rs627634,rs67846163,rs6809328,rs6974735,rs7009229,rs72931764,rs73136870,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs934012
ascending aorta minimum area	Aortic aneurysm	IX Diseases of the circulatory system (I9_)	MR Egger	50	0.48	0.26	7.74E-02	0.31	rs10059884,rs10089014,rs1108450,rs11207420,rs112858262,rs12771055,rs13128814,rs1441358,rs150260620,rs1561207,rs1630736,rs1689549,rs17323291,rs178406,rs1862771,rs2255266,rs2429917,rs2463475,rs2515289,rs2686630,rs2871651,rs34557926,rs34968301,rs434775,rs4724032,rs4791494,rs4840467,rs488327,rs4905134,rs55745974,rs57774511,rs62053262,rs62270945,rs67846163,rs6809328,rs6964590,rs7009229,rs7168391,rs73139037,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs861202,rs875107,rs889509,rs934012
ascending aorta minimum area	Aortic aneurysm	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (fixed effects)	50	0.73	0.05	1.85E-45	0.31	rs10059884,rs10089014,rs1108450,rs11207420,rs112858262,rs12771055,rs13128814,rs1441358,rs150260620,rs1561207,rs1630736,rs1689549,rs17323291,rs178406,rs1862771,rs2255266,rs2429917,rs2463475,rs2515289,rs2686630,rs2871651,rs34557926,rs34968301,rs434775,rs4724032,rs4791494,rs4840467,rs488327,rs4905134,rs55745974,rs57774511,rs62053262,rs62270945,rs67846163,rs6809328,rs6964590,rs7009229,rs7168391,rs73139037,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs861202,rs875107,rs889509,rs934012
ascending aorta minimum area	Aortic aneurysm	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (multiplicative random effects)	50	0.73	0.09	8.65E-18	0.31	rs10059884,rs10089014,rs1108450,rs11207420,rs112858262,rs12771055,rs13128814,rs1441358,rs150260620,rs1561207,rs1630736,rs1689549,rs17323291,rs178406,rs1862771,rs2255266,rs2429917,rs2463475,rs2515289,rs2686630,rs2871651,rs34557926,rs34968301,rs434775,rs4724032,rs4791494,rs4840467,rs488327,rs4905134,rs55745974,rs57774511,rs62053262,rs62270945,rs67846163,rs6809328,rs6964590,rs7009229,rs7168391,rs73139037,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs861202,rs875107,rs889509,rs934012
ascending aorta minimum area	Aortic aneurysm	IX Diseases of the circulatory system (I9_)	Weighted mode	50	0.46	0.21	3.10E-02	0.31	rs10059884,rs10089014,rs1108450,rs11207420,rs112858262,rs12771055,rs13128814,rs1441358,rs150260620,rs1561207,rs1630736,rs1689549,rs17323291,rs178406,rs1862771,rs2255266,rs2429917,rs2463475,rs2515289,rs2686630,rs2871651,rs34557926,rs34968301,rs434775,rs4724032,rs4791494,rs4840467,rs488327,rs4905134,rs55745974,rs57774511,rs62053262,rs62270945,rs67846163,rs6809328,rs6964590,rs7009229,rs7168391,rs73139037,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs861202,rs875107,rs889509,rs934012
ascending aorta minimum area	Aortic aneurysm	IX Diseases of the circulatory system (I9_)	Weighted median	50	0.57	0.09	4.66E-10	0.31	rs10059884,rs10089014,rs1108450,rs11207420,rs112858262,rs12771055,rs13128814,rs1441358,rs150260620,rs1561207,rs1630736,rs1689549,rs17323291,rs178406,rs1862771,rs2255266,rs2429917,rs2463475,rs2515289,rs2686630,rs2871651,rs34557926,rs34968301,rs434775,rs4724032,rs4791494,rs4840467,rs488327,rs4905134,rs55745974,rs57774511,rs62053262,rs62270945,rs67846163,rs6809328,rs6964590,rs7009229,rs7168391,rs73139037,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs861202,rs875107,rs889509,rs934012
ascending aorta minimum area	Aortic aneurysm	IX Diseases of the circulatory system (I9_)	DIVW	50	0.75	0.05	0.00E+00	0.31	rs10059884,rs10089014,rs1108450,rs11207420,rs112858262,rs12771055,rs13128814,rs1441358,rs150260620,rs1561207,rs1630736,rs1689549,rs17323291,rs178406,rs1862771,rs2255266,rs2429917,rs2463475,rs2515289,rs2686630,rs2871651,rs34557926,rs34968301,rs434775,rs4724032,rs4791494,rs4840467,rs488327,rs4905134,rs55745974,rs57774511,rs62053262,rs62270945,rs67846163,rs6809328,rs6964590,rs7009229,rs7168391,rs73139037,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs861202,rs875107,rs889509,rs934012
ascending aorta minimum area	Aortic aneurysm	IX Diseases of the circulatory system (I9_)	GRAPPLE	50	0.72	0.09	5.51E-16	0.31	rs10059884,rs10089014,rs1108450,rs11207420,rs112858262,rs12771055,rs13128814,rs1441358,rs150260620,rs1561207,rs1630736,rs1689549,rs17323291,rs178406,rs1862771,rs2255266,rs2429917,rs2463475,rs2515289,rs2686630,rs2871651,rs34557926,rs34968301,rs434775,rs4724032,rs4791494,rs4840467,rs488327,rs4905134,rs55745974,rs57774511,rs62053262,rs62270945,rs67846163,rs6809328,rs6964590,rs7009229,rs7168391,rs73139037,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs861202,rs875107,rs889509,rs934012
ascending aorta minimum area	Aortic aneurysm	IX Diseases of the circulatory system (I9_)	mr_raps	50	0.76	0.06	0.00E+00	0.31	rs10059884,rs10089014,rs1108450,rs11207420,rs112858262,rs12771055,rs13128814,rs1441358,rs150260620,rs1561207,rs1630736,rs1689549,rs17323291,rs178406,rs1862771,rs2255266,rs2429917,rs2463475,rs2515289,rs2686630,rs2871651,rs34557926,rs34968301,rs434775,rs4724032,rs4791494,rs4840467,rs488327,rs4905134,rs55745974,rs57774511,rs62053262,rs62270945,rs67846163,rs6809328,rs6964590,rs7009229,rs7168391,rs73139037,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs861202,rs875107,rs889509,rs934012
ascending aorta minimum area	Diseases of arteries, arterioles and capillaries	IX Diseases of the circulatory system (I9_)	MR Egger	50	0.15	0.15	3.05E-01	0.79	rs10059884,rs10089014,rs1108450,rs11207420,rs112858262,rs12771055,rs13128814,rs1441358,rs150260620,rs1561207,rs1630736,rs1689549,rs17323291,rs178406,rs1862771,rs2255266,rs2429917,rs2463475,rs2515289,rs2686630,rs2871651,rs34557926,rs34968301,rs434775,rs4724032,rs4791494,rs4840467,rs488327,rs4905134,rs55745974,rs57774511,rs62053262,rs62270945,rs67846163,rs6809328,rs6964590,rs7009229,rs7168391,rs73139037,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs861202,rs875107,rs889509,rs934012
ascending aorta minimum area	Diseases of arteries, arterioles and capillaries	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (fixed effects)	50	0.19	0.03	1.44E-10	0.79	rs10059884,rs10089014,rs1108450,rs11207420,rs112858262,rs12771055,rs13128814,rs1441358,rs150260620,rs1561207,rs1630736,rs1689549,rs17323291,rs178406,rs1862771,rs2255266,rs2429917,rs2463475,rs2515289,rs2686630,rs2871651,rs34557926,rs34968301,rs434775,rs4724032,rs4791494,rs4840467,rs488327,rs4905134,rs55745974,rs57774511,rs62053262,rs62270945,rs67846163,rs6809328,rs6964590,rs7009229,rs7168391,rs73139037,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs861202,rs875107,rs889509,rs934012
ascending aorta minimum area	Diseases of arteries, arterioles and capillaries	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (multiplicative random effects)	50	0.19	0.05	5.75E-05	0.79	rs10059884,rs10089014,rs1108450,rs11207420,rs112858262,rs12771055,rs13128814,rs1441358,rs150260620,rs1561207,rs1630736,rs1689549,rs17323291,rs178406,rs1862771,rs2255266,rs2429917,rs2463475,rs2515289,rs2686630,rs2871651,rs34557926,rs34968301,rs434775,rs4724032,rs4791494,rs4840467,rs488327,rs4905134,rs55745974,rs57774511,rs62053262,rs62270945,rs67846163,rs6809328,rs6964590,rs7009229,rs7168391,rs73139037,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs861202,rs875107,rs889509,rs934012
ascending aorta minimum area	Diseases of arteries, arterioles and capillaries	IX Diseases of the circulatory system (I9_)	Weighted mode	50	0.13	0.10	1.84E-01	0.79	rs10059884,rs10089014,rs1108450,rs11207420,rs112858262,rs12771055,rs13128814,rs1441358,rs150260620,rs1561207,rs1630736,rs1689549,rs17323291,rs178406,rs1862771,rs2255266,rs2429917,rs2463475,rs2515289,rs2686630,rs2871651,rs34557926,rs34968301,rs434775,rs4724032,rs4791494,rs4840467,rs488327,rs4905134,rs55745974,rs57774511,rs62053262,rs62270945,rs67846163,rs6809328,rs6964590,rs7009229,rs7168391,rs73139037,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs861202,rs875107,rs889509,rs934012
ascending aorta minimum area	Diseases of arteries, arterioles and capillaries	IX Diseases of the circulatory system (I9_)	Weighted median	50	0.14	0.05	4.16E-03	0.79	rs10059884,rs10089014,rs1108450,rs11207420,rs112858262,rs12771055,rs13128814,rs1441358,rs150260620,rs1561207,rs1630736,rs1689549,rs17323291,rs178406,rs1862771,rs2255266,rs2429917,rs2463475,rs2515289,rs2686630,rs2871651,rs34557926,rs34968301,rs434775,rs4724032,rs4791494,rs4840467,rs488327,rs4905134,rs55745974,rs57774511,rs62053262,rs62270945,rs67846163,rs6809328,rs6964590,rs7009229,rs7168391,rs73139037,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs861202,rs875107,rs889509,rs934012
ascending aorta minimum area	Diseases of arteries, arterioles and capillaries	IX Diseases of the circulatory system (I9_)	DIVW	50	0.19	0.03	1.01E-10	0.79	rs10059884,rs10089014,rs1108450,rs11207420,rs112858262,rs12771055,rs13128814,rs1441358,rs150260620,rs1561207,rs1630736,rs1689549,rs17323291,rs178406,rs1862771,rs2255266,rs2429917,rs2463475,rs2515289,rs2686630,rs2871651,rs34557926,rs34968301,rs434775,rs4724032,rs4791494,rs4840467,rs488327,rs4905134,rs55745974,rs57774511,rs62053262,rs62270945,rs67846163,rs6809328,rs6964590,rs7009229,rs7168391,rs73139037,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs861202,rs875107,rs889509,rs934012
ascending aorta minimum area	Diseases of arteries, arterioles and capillaries	IX Diseases of the circulatory system (I9_)	GRAPPLE	50	0.20	0.05	3.43E-05	0.79	rs10059884,rs10089014,rs1108450,rs11207420,rs112858262,rs12771055,rs13128814,rs1441358,rs150260620,rs1561207,rs1630736,rs1689549,rs17323291,rs178406,rs1862771,rs2255266,rs2429917,rs2463475,rs2515289,rs2686630,rs2871651,rs34557926,rs34968301,rs434775,rs4724032,rs4791494,rs4840467,rs488327,rs4905134,rs55745974,rs57774511,rs62053262,rs62270945,rs67846163,rs6809328,rs6964590,rs7009229,rs7168391,rs73139037,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs861202,rs875107,rs889509,rs934012
ascending aorta minimum area	Diseases of arteries, arterioles and capillaries	IX Diseases of the circulatory system (I9_)	mr_raps	50	0.18	0.03	1.50E-09	0.79	rs10059884,rs10089014,rs1108450,rs11207420,rs112858262,rs12771055,rs13128814,rs1441358,rs150260620,rs1561207,rs1630736,rs1689549,rs17323291,rs178406,rs1862771,rs2255266,rs2429917,rs2463475,rs2515289,rs2686630,rs2871651,rs34557926,rs34968301,rs434775,rs4724032,rs4791494,rs4840467,rs488327,rs4905134,rs55745974,rs57774511,rs62053262,rs62270945,rs67846163,rs6809328,rs6964590,rs7009229,rs7168391,rs73139037,rs7342028,rs747249,rs7500448,rs7744333,rs7748987,rs79215950,rs7994761,rs861202,rs875107,rs889509,rs934012
descending aorta minimum area	Aortic aneurysm	IX Diseases of the circulatory system (I9_)	MR Egger	27	0.38	0.69	5.87E-01	0.59	rs1048661,rs10740811,rs11640724,rs11844114,rs12139318,rs12905240,rs12956065,rs1437403,rs148873942,rs17352842,rs2077218,rs2107595,rs2177153,rs3006554,rs3128981,rs35247409,rs452036,rs4665026,rs4707174,rs55747751,rs59945167,rs650720,rs698099,rs7255,rs77870048,rs8043119,rs871606
descending aorta minimum area	Aortic aneurysm	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (fixed effects)	27	0.74	0.09	4.05E-16	0.59	rs1048661,rs10740811,rs11640724,rs11844114,rs12139318,rs12905240,rs12956065,rs1437403,rs148873942,rs17352842,rs2077218,rs2107595,rs2177153,rs3006554,rs3128981,rs35247409,rs452036,rs4665026,rs4707174,rs55747751,rs59945167,rs650720,rs698099,rs7255,rs77870048,rs8043119,rs871606
descending aorta minimum area	Aortic aneurysm	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (multiplicative random effects)	27	0.74	0.18	3.07E-05	0.59	rs1048661,rs10740811,rs11640724,rs11844114,rs12139318,rs12905240,rs12956065,rs1437403,rs148873942,rs17352842,rs2077218,rs2107595,rs2177153,rs3006554,rs3128981,rs35247409,rs452036,rs4665026,rs4707174,rs55747751,rs59945167,rs650720,rs698099,rs7255,rs77870048,rs8043119,rs871606
descending aorta minimum area	Aortic aneurysm	IX Diseases of the circulatory system (I9_)	Weighted mode	27	0.25	0.22	2.80E-01	0.59	rs1048661,rs10740811,rs11640724,rs11844114,rs12139318,rs12905240,rs12956065,rs1437403,rs148873942,rs17352842,rs2077218,rs2107595,rs2177153,rs3006554,rs3128981,rs35247409,rs452036,rs4665026,rs4707174,rs55747751,rs59945167,rs650720,rs698099,rs7255,rs77870048,rs8043119,rs871606
descending aorta minimum area	Aortic aneurysm	IX Diseases of the circulatory system (I9_)	Weighted median	27	0.48	0.17	4.15E-03	0.59	rs1048661,rs10740811,rs11640724,rs11844114,rs12139318,rs12905240,rs12956065,rs1437403,rs148873942,rs17352842,rs2077218,rs2107595,rs2177153,rs3006554,rs3128981,rs35247409,rs452036,rs4665026,rs4707174,rs55747751,rs59945167,rs650720,rs698099,rs7255,rs77870048,rs8043119,rs871606
descending aorta minimum area	Aortic aneurysm	IX Diseases of the circulatory system (I9_)	DIVW	27	0.76	0.10	1.44E-15	0.59	rs1048661,rs10740811,rs11640724,rs11844114,rs12139318,rs12905240,rs12956065,rs1437403,rs148873942,rs17352842,rs2077218,rs2107595,rs2177153,rs3006554,rs3128981,rs35247409,rs452036,rs4665026,rs4707174,rs55747751,rs59945167,rs650720,rs698099,rs7255,rs77870048,rs8043119,rs871606
descending aorta minimum area	Aortic aneurysm	IX Diseases of the circulatory system (I9_)	GRAPPLE	27	0.72	0.20	3.53E-04	0.59	rs1048661,rs10740811,rs11640724,rs11844114,rs12139318,rs12905240,rs12956065,rs1437403,rs148873942,rs17352842,rs2077218,rs2107595,rs2177153,rs3006554,rs3128981,rs35247409,rs452036,rs4665026,rs4707174,rs55747751,rs59945167,rs650720,rs698099,rs7255,rs77870048,rs8043119,rs871606
descending aorta minimum area	Aortic aneurysm	IX Diseases of the circulatory system (I9_)	mr_raps	27	0.69	0.10	4.06E-13	0.59	rs1048661,rs10740811,rs11640724,rs11844114,rs12139318,rs12905240,rs12956065,rs1437403,rs148873942,rs17352842,rs2077218,rs2107595,rs2177153,rs3006554,rs3128981,rs35247409,rs452036,rs4665026,rs4707174,rs55747751,rs59945167,rs650720,rs698099,rs7255,rs77870048,rs8043119,rs871606
global myocardial-wall thickness at end-diastole	Hypertension	IX Diseases of the circulatory system (I9_)	MR Egger	12	-1.08	0.97	2.92E-01	0.18	rs11604825,rs13198983,rs2018860,rs2070458,rs2681492,rs2696542,rs4151702,rs4820654,rs497999,rs61872561,rs621679,rs62253185
global myocardial-wall thickness at end-diastole	Hypertension	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (fixed effects)	12	0.28	0.06	5.74E-07	0.18	rs11604825,rs13198983,rs2018860,rs2070458,rs2681492,rs2696542,rs4151702,rs4820654,rs497999,rs61872561,rs621679,rs62253185
global myocardial-wall thickness at end-diastole	Hypertension	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (multiplicative random effects)	12	0.28	0.23	2.12E-01	0.18	rs11604825,rs13198983,rs2018860,rs2070458,rs2681492,rs2696542,rs4151702,rs4820654,rs497999,rs61872561,rs621679,rs62253185
global myocardial-wall thickness at end-diastole	Hypertension	IX Diseases of the circulatory system (I9_)	Weighted mode	12	0.08	0.09	3.80E-01	0.18	rs11604825,rs13198983,rs2018860,rs2070458,rs2681492,rs2696542,rs4151702,rs4820654,rs497999,rs61872561,rs621679,rs62253185
global myocardial-wall thickness at end-diastole	Hypertension	IX Diseases of the circulatory system (I9_)	Weighted median	12	0.05	0.10	5.84E-01	0.18	rs11604825,rs13198983,rs2018860,rs2070458,rs2681492,rs2696542,rs4151702,rs4820654,rs497999,rs61872561,rs621679,rs62253185
global myocardial-wall thickness at end-diastole	Hypertension	IX Diseases of the circulatory system (I9_)	DIVW	12	0.29	0.06	5.78E-07	0.18	rs11604825,rs13198983,rs2018860,rs2070458,rs2681492,rs2696542,rs4151702,rs4820654,rs497999,rs61872561,rs621679,rs62253185
global myocardial-wall thickness at end-diastole	Hypertension	IX Diseases of the circulatory system (I9_)	GRAPPLE	12	0.00	0.25	9.88E-01	0.18	rs11604825,rs13198983,rs2018860,rs2070458,rs2681492,rs2696542,rs4151702,rs4820654,rs497999,rs61872561,rs621679,rs62253185
global myocardial-wall thickness at end-diastole	Hypertension	IX Diseases of the circulatory system (I9_)	mr_raps	12	0.11	0.05	2.37E-02	0.18	rs11604825,rs13198983,rs2018860,rs2070458,rs2681492,rs2696542,rs4151702,rs4820654,rs497999,rs61872561,rs621679,rs62253185
global peak circumferential strain	Heart failure and antihypertensive medication	Cardiometabolic endpoints	MR Egger	10	0.45	0.83	5.97E-01	0.94	rs10057570,rs11715059,rs12544084,rs12988307,rs17617337,rs3176326,rs55807228,rs61775418,rs643420,rs9909004
global peak circumferential strain	Heart failure and antihypertensive medication	Cardiometabolic endpoints	Inverse variance weighted (fixed effects)	10	0.51	0.09	5.96E-08	0.94	rs10057570,rs11715059,rs12544084,rs12988307,rs17617337,rs3176326,rs55807228,rs61775418,rs643420,rs9909004
global peak circumferential strain	Heart failure and antihypertensive medication	Cardiometabolic endpoints	Inverse variance weighted (multiplicative random effects)	10	0.51	0.17	2.73E-03	0.94	rs10057570,rs11715059,rs12544084,rs12988307,rs17617337,rs3176326,rs55807228,rs61775418,rs643420,rs9909004
global peak circumferential strain	Heart failure and antihypertensive medication	Cardiometabolic endpoints	Weighted mode	10	0.55	0.28	8.61E-02	0.94	rs10057570,rs11715059,rs12544084,rs12988307,rs17617337,rs3176326,rs55807228,rs61775418,rs643420,rs9909004
global peak circumferential strain	Heart failure and antihypertensive medication	Cardiometabolic endpoints	Weighted median	10	0.59	0.16	1.41E-04	0.94	rs10057570,rs11715059,rs12544084,rs12988307,rs17617337,rs3176326,rs55807228,rs61775418,rs643420,rs9909004
global peak circumferential strain	Heart failure and antihypertensive medication	Cardiometabolic endpoints	DIVW	10	0.52	0.10	8.49E-08	0.94	rs10057570,rs11715059,rs12544084,rs12988307,rs17617337,rs3176326,rs55807228,rs61775418,rs643420,rs9909004
global peak circumferential strain	Heart failure and antihypertensive medication	Cardiometabolic endpoints	GRAPPLE	10	0.52	0.19	5.40E-03	0.94	rs10057570,rs11715059,rs12544084,rs12988307,rs17617337,rs3176326,rs55807228,rs61775418,rs643420,rs9909004
global peak circumferential strain	Heart failure and antihypertensive medication	Cardiometabolic endpoints	mr_raps	10	0.57	0.10	2.26E-08	0.94	rs10057570,rs11715059,rs12544084,rs12988307,rs17617337,rs3176326,rs55807228,rs61775418,rs643420,rs9909004
global peak circumferential strain	Heart failure,strict	IX Diseases of the circulatory system (I9_)	MR Egger	10	0.02	0.72	9.73E-01	0.62	rs10057570,rs11715059,rs12544084,rs12988307,rs17617337,rs3176326,rs55807228,rs61775418,rs643420,rs9909004
global peak circumferential strain	Heart failure,strict	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (fixed effects)	10	0.39	0.08	6.87E-07	0.62	rs10057570,rs11715059,rs12544084,rs12988307,rs17617337,rs3176326,rs55807228,rs61775418,rs643420,rs9909004
global peak circumferential strain	Heart failure,strict	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (multiplicative random effects)	10	0.39	0.15	1.07E-02	0.62	rs10057570,rs11715059,rs12544084,rs12988307,rs17617337,rs3176326,rs55807228,rs61775418,rs643420,rs9909004
global peak circumferential strain	Heart failure,strict	IX Diseases of the circulatory system (I9_)	Weighted mode	10	0.35	0.14	3.45E-02	0.62	rs10057570,rs11715059,rs12544084,rs12988307,rs17617337,rs3176326,rs55807228,rs61775418,rs643420,rs9909004
global peak circumferential strain	Heart failure,strict	IX Diseases of the circulatory system (I9_)	Weighted median	10	0.37	0.11	1.27E-03	0.62	rs10057570,rs11715059,rs12544084,rs12988307,rs17617337,rs3176326,rs55807228,rs61775418,rs643420,rs9909004
global peak circumferential strain	Heart failure,strict	IX Diseases of the circulatory system (I9_)	DIVW	10	0.40	0.08	7.27E-07	0.62	rs10057570,rs11715059,rs12544084,rs12988307,rs17617337,rs3176326,rs55807228,rs61775418,rs643420,rs9909004
global peak circumferential strain	Heart failure,strict	IX Diseases of the circulatory system (I9_)	GRAPPLE	10	0.35	0.17	3.56E-02	0.62	rs10057570,rs11715059,rs12544084,rs12988307,rs17617337,rs3176326,rs55807228,rs61775418,rs643420,rs9909004
global peak circumferential strain	Heart failure,strict	IX Diseases of the circulatory system (I9_)	mr_raps	10	0.39	0.08	2.48E-06	0.62	rs10057570,rs11715059,rs12544084,rs12988307,rs17617337,rs3176326,rs55807228,rs61775418,rs643420,rs9909004
left ventricular ejection fraction	Heart failure and antihypertensive medication	Cardiometabolic endpoints	MR Egger	6	-0.66	0.57	3.09E-01	0.86	rs17165121,rs17617337,rs2562845,rs2848917,rs34866937,rs9442217
left ventricular ejection fraction	Heart failure and antihypertensive medication	Cardiometabolic endpoints	Inverse variance weighted (fixed effects)	6	-0.55	0.10	8.11E-09	0.86	rs17165121,rs17617337,rs2562845,rs2848917,rs34866937,rs9442217
left ventricular ejection fraction	Heart failure and antihypertensive medication	Cardiometabolic endpoints	Inverse variance weighted (multiplicative random effects)	6	-0.55	0.10	9.98E-08	0.86	rs17165121,rs17617337,rs2562845,rs2848917,rs34866937,rs9442217
left ventricular ejection fraction	Heart failure and antihypertensive medication	Cardiometabolic endpoints	Weighted mode	6	-0.69	0.17	9.29E-03	0.86	rs17165121,rs17617337,rs2562845,rs2848917,rs34866937,rs9442217
left ventricular ejection fraction	Heart failure and antihypertensive medication	Cardiometabolic endpoints	Weighted median	6	-0.69	0.13	4.62E-08	0.86	rs17165121,rs17617337,rs2562845,rs2848917,rs34866937,rs9442217
left ventricular ejection fraction	Heart failure and antihypertensive medication	Cardiometabolic endpoints	DIVW	6	-0.56	0.10	1.93E-08	0.86	rs17165121,rs17617337,rs2562845,rs2848917,rs34866937,rs9442217
left ventricular ejection fraction	Heart failure and antihypertensive medication	Cardiometabolic endpoints	GRAPPLE	6	-0.58	0.11	1.12E-07	0.86	rs17165121,rs17617337,rs2562845,rs2848917,rs34866937,rs9442217
left ventricular ejection fraction	Heart failure and antihypertensive medication	Cardiometabolic endpoints	mr_raps	6	-0.59	0.11	2.53E-08	0.86	rs17165121,rs17617337,rs2562845,rs2848917,rs34866937,rs9442217
left ventricular end-diastolic volume	Autoimmune diseases	Diseases marked as autimmune origin	MR Egger	8	0.39	2.81	8.95E-01	0.78	rs117550412,rs12988307,rs2267038,rs381999,rs4980389,rs653178,rs7502466,rs7573293
left ventricular end-diastolic volume	Autoimmune diseases	Diseases marked as autimmune origin	Inverse variance weighted (fixed effects)	8	-0.42	0.06	6.02E-13	0.78	rs117550412,rs12988307,rs2267038,rs381999,rs4980389,rs653178,rs7502466,rs7573293
left ventricular end-diastolic volume	Autoimmune diseases	Diseases marked as autimmune origin	Inverse variance weighted (multiplicative random effects)	8	-0.42	0.41	3.02E-01	0.78	rs117550412,rs12988307,rs2267038,rs381999,rs4980389,rs653178,rs7502466,rs7573293
left ventricular end-diastolic volume	Autoimmune diseases	Diseases marked as autimmune origin	Weighted mode	8	-0.04	0.09	6.74E-01	0.78	rs117550412,rs12988307,rs2267038,rs381999,rs4980389,rs653178,rs7502466,rs7573293
left ventricular end-diastolic volume	Autoimmune diseases	Diseases marked as autimmune origin	Weighted median	8	-0.01	0.08	8.87E-01	0.78	rs117550412,rs12988307,rs2267038,rs381999,rs4980389,rs653178,rs7502466,rs7573293
left ventricular end-diastolic volume	Autoimmune diseases	Diseases marked as autimmune origin	DIVW	8	-0.43	0.06	1.44E-11	0.78	rs117550412,rs12988307,rs2267038,rs381999,rs4980389,rs653178,rs7502466,rs7573293
left ventricular end-diastolic volume	Autoimmune diseases	Diseases marked as autimmune origin	GRAPPLE	8	-0.16	0.33	6.25E-01	0.78	rs117550412,rs12988307,rs2267038,rs381999,rs4980389,rs653178,rs7502466,rs7573293
left ventricular end-diastolic volume	Autoimmune diseases	Diseases marked as autimmune origin	mr_raps	8	-0.06	0.04	1.54E-01	0.78	rs117550412,rs12988307,rs2267038,rs381999,rs4980389,rs653178,rs7502466,rs7573293
left ventricular end-diastolic volume	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	MR Egger	8	-4.45	1.96	6.35E-02	0.10	rs117550412,rs12988307,rs2267038,rs381999,rs4980389,rs653178,rs7502466,rs7573293
left ventricular end-diastolic volume	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (fixed effects)	8	-0.64	0.11	1.99E-09	0.10	rs117550412,rs12988307,rs2267038,rs381999,rs4980389,rs653178,rs7502466,rs7573293
left ventricular end-diastolic volume	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (multiplicative random effects)	8	-0.64	0.36	7.84E-02	0.10	rs117550412,rs12988307,rs2267038,rs381999,rs4980389,rs653178,rs7502466,rs7573293
left ventricular end-diastolic volume	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	Weighted mode	8	-0.44	0.26	1.35E-01	0.10	rs117550412,rs12988307,rs2267038,rs381999,rs4980389,rs653178,rs7502466,rs7573293
left ventricular end-diastolic volume	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	Weighted median	8	-0.44	0.19	2.28E-02	0.10	rs117550412,rs12988307,rs2267038,rs381999,rs4980389,rs653178,rs7502466,rs7573293
left ventricular end-diastolic volume	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	DIVW	8	-0.65	0.12	7.13E-09	0.10	rs117550412,rs12988307,rs2267038,rs381999,rs4980389,rs653178,rs7502466,rs7573293
left ventricular end-diastolic volume	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	GRAPPLE	8	-0.51	0.40	2.05E-01	0.10	rs117550412,rs12988307,rs2267038,rs381999,rs4980389,rs653178,rs7502466,rs7573293
left ventricular end-diastolic volume	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	mr_raps	8	-0.63	0.11	2.90E-09	0.10	rs117550412,rs12988307,rs2267038,rs381999,rs4980389,rs653178,rs7502466,rs7573293
left ventricular myocardial mass	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	MR Egger	6	-3.51	2.39	2.17E-01	0.29	rs12988307,rs13198983,rs2871974,rs621679,rs7102372,rs931992
left ventricular myocardial mass	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (fixed effects)	6	-0.66	0.14	4.07E-06	0.29	rs12988307,rs13198983,rs2871974,rs621679,rs7102372,rs931992
left ventricular myocardial mass	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (multiplicative random effects)	6	-0.66	0.59	2.62E-01	0.29	rs12988307,rs13198983,rs2871974,rs621679,rs7102372,rs931992
left ventricular myocardial mass	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	Weighted mode	6	-1.49	0.41	1.46E-02	0.29	rs12988307,rs13198983,rs2871974,rs621679,rs7102372,rs931992
left ventricular myocardial mass	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	Weighted median	6	-0.85	0.29	3.53E-03	0.29	rs12988307,rs13198983,rs2871974,rs621679,rs7102372,rs931992
left ventricular myocardial mass	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	DIVW	6	-0.68	0.15	4.97E-06	0.29	rs12988307,rs13198983,rs2871974,rs621679,rs7102372,rs931992
left ventricular myocardial mass	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	GRAPPLE	6	-0.80	0.61	1.89E-01	0.29	rs12988307,rs13198983,rs2871974,rs621679,rs7102372,rs931992
left ventricular myocardial mass	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	mr_raps	6	-1.22	0.16	6.31E-14	0.29	rs12988307,rs13198983,rs2871974,rs621679,rs7102372,rs931992
left ventricular myocardial mass	Hypertension	IX Diseases of the circulatory system (I9_)	MR Egger	6	-0.76	1.92	7.14E-01	0.56	rs12988307,rs13198983,rs2871974,rs621679,rs7102372,rs931992
left ventricular myocardial mass	Hypertension	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (fixed effects)	6	0.43	0.08	3.42E-07	0.56	rs12988307,rs13198983,rs2871974,rs621679,rs7102372,rs931992
left ventricular myocardial mass	Hypertension	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (multiplicative random effects)	6	0.43	0.42	3.09E-01	0.56	rs12988307,rs13198983,rs2871974,rs621679,rs7102372,rs931992
left ventricular myocardial mass	Hypertension	IX Diseases of the circulatory system (I9_)	Weighted mode	6	-0.09	0.13	5.25E-01	0.56	rs12988307,rs13198983,rs2871974,rs621679,rs7102372,rs931992
left ventricular myocardial mass	Hypertension	IX Diseases of the circulatory system (I9_)	Weighted median	6	-0.01	0.14	9.32E-01	0.56	rs12988307,rs13198983,rs2871974,rs621679,rs7102372,rs931992
left ventricular myocardial mass	Hypertension	IX Diseases of the circulatory system (I9_)	DIVW	6	0.44	0.09	6.30E-07	0.56	rs12988307,rs13198983,rs2871974,rs621679,rs7102372,rs931992
left ventricular myocardial mass	Hypertension	IX Diseases of the circulatory system (I9_)	GRAPPLE	6	0.30	0.42	4.75E-01	0.56	rs12988307,rs13198983,rs2871974,rs621679,rs7102372,rs931992
left ventricular myocardial mass	Hypertension	IX Diseases of the circulatory system (I9_)	mr_raps	6	1.38	0.14	0.00E+00	0.56	rs12988307,rs13198983,rs2871974,rs621679,rs7102372,rs931992
regional myocardial-wall thickness at end-diastole 10	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	MR Egger	8	0.31	1.70	8.60E-01	0.62	rs13198983,rs143800963,rs2018860,rs2532330,rs3803405,rs61870180,rs6723399,rs9462207
regional myocardial-wall thickness at end-diastole 10	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (fixed effects)	8	-0.54	0.11	2.53E-06	0.62	rs13198983,rs143800963,rs2018860,rs2532330,rs3803405,rs61870180,rs6723399,rs9462207
regional myocardial-wall thickness at end-diastole 10	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (multiplicative random effects)	8	-0.54	0.44	2.25E-01	0.62	rs13198983,rs143800963,rs2018860,rs2532330,rs3803405,rs61870180,rs6723399,rs9462207
regional myocardial-wall thickness at end-diastole 10	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	Weighted mode	8	-0.04	0.27	8.83E-01	0.62	rs13198983,rs143800963,rs2018860,rs2532330,rs3803405,rs61870180,rs6723399,rs9462207
regional myocardial-wall thickness at end-diastole 10	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	Weighted median	8	-0.13	0.24	5.90E-01	0.62	rs13198983,rs143800963,rs2018860,rs2532330,rs3803405,rs61870180,rs6723399,rs9462207
regional myocardial-wall thickness at end-diastole 10	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	DIVW	8	-0.55	0.12	3.24E-06	0.62	rs13198983,rs143800963,rs2018860,rs2532330,rs3803405,rs61870180,rs6723399,rs9462207
regional myocardial-wall thickness at end-diastole 10	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	GRAPPLE	8	-0.29	0.40	4.62E-01	0.62	rs13198983,rs143800963,rs2018860,rs2532330,rs3803405,rs61870180,rs6723399,rs9462207
regional myocardial-wall thickness at end-diastole 10	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	mr_raps	8	-0.80	0.12	1.83E-11	0.62	rs13198983,rs143800963,rs2018860,rs2532330,rs3803405,rs61870180,rs6723399,rs9462207
regional myocardial-wall thickness at end-diastole 10	Other heart diseases	IX Diseases of the circulatory system (I9_)	MR Egger	8	0.16	0.60	7.93E-01	0.46	rs13198983,rs143800963,rs2018860,rs2532330,rs3803405,rs61870180,rs6723399,rs9462207
regional myocardial-wall thickness at end-diastole 10	Other heart diseases	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (fixed effects)	8	-0.29	0.06	5.06E-06	0.46	rs13198983,rs143800963,rs2018860,rs2532330,rs3803405,rs61870180,rs6723399,rs9462207
regional myocardial-wall thickness at end-diastole 10	Other heart diseases	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (multiplicative random effects)	8	-0.29	0.16	6.80E-02	0.46	rs13198983,rs143800963,rs2018860,rs2532330,rs3803405,rs61870180,rs6723399,rs9462207
regional myocardial-wall thickness at end-diastole 10	Other heart diseases	IX Diseases of the circulatory system (I9_)	Weighted mode	8	0.08	0.23	7.34E-01	0.46	rs13198983,rs143800963,rs2018860,rs2532330,rs3803405,rs61870180,rs6723399,rs9462207
regional myocardial-wall thickness at end-diastole 10	Other heart diseases	IX Diseases of the circulatory system (I9_)	Weighted median	8	-0.24	0.13	6.87E-02	0.46	rs13198983,rs143800963,rs2018860,rs2532330,rs3803405,rs61870180,rs6723399,rs9462207
regional myocardial-wall thickness at end-diastole 10	Other heart diseases	IX Diseases of the circulatory system (I9_)	DIVW	8	-0.30	0.07	5.84E-06	0.46	rs13198983,rs143800963,rs2018860,rs2532330,rs3803405,rs61870180,rs6723399,rs9462207
regional myocardial-wall thickness at end-diastole 10	Other heart diseases	IX Diseases of the circulatory system (I9_)	GRAPPLE	8	-0.24	0.16	1.29E-01	0.46	rs13198983,rs143800963,rs2018860,rs2532330,rs3803405,rs61870180,rs6723399,rs9462207
regional myocardial-wall thickness at end-diastole 10	Other heart diseases	IX Diseases of the circulatory system (I9_)	mr_raps	8	-0.49	0.07	3.44E-11	0.46	rs13198983,rs143800963,rs2018860,rs2532330,rs3803405,rs61870180,rs6723399,rs9462207
regional myocardial-wall thickness at end-diastole 11	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	MR Egger	9	0.89	1.32	5.21E-01	0.33	rs12453217,rs2070458,rs2696524,rs3803405,rs4965428,rs57610221,rs61775418,rs62253182,rs730506
regional myocardial-wall thickness at end-diastole 11	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (fixed effects)	9	-0.47	0.10	1.21E-06	0.33	rs12453217,rs2070458,rs2696524,rs3803405,rs4965428,rs57610221,rs61775418,rs62253182,rs730506
regional myocardial-wall thickness at end-diastole 11	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (multiplicative random effects)	9	-0.47	0.28	8.94E-02	0.33	rs12453217,rs2070458,rs2696524,rs3803405,rs4965428,rs57610221,rs61775418,rs62253182,rs730506
regional myocardial-wall thickness at end-diastole 11	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	Weighted mode	9	-0.60	0.16	6.29E-03	0.33	rs12453217,rs2070458,rs2696524,rs3803405,rs4965428,rs57610221,rs61775418,rs62253182,rs730506
regional myocardial-wall thickness at end-diastole 11	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	Weighted median	9	-0.51	0.16	1.14E-03	0.33	rs12453217,rs2070458,rs2696524,rs3803405,rs4965428,rs57610221,rs61775418,rs62253182,rs730506
regional myocardial-wall thickness at end-diastole 11	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	DIVW	9	-0.48	0.10	1.22E-06	0.33	rs12453217,rs2070458,rs2696524,rs3803405,rs4965428,rs57610221,rs61775418,rs62253182,rs730506
regional myocardial-wall thickness at end-diastole 11	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	GRAPPLE	9	-0.40	0.33	2.16E-01	0.33	rs12453217,rs2070458,rs2696524,rs3803405,rs4965428,rs57610221,rs61775418,rs62253182,rs730506
regional myocardial-wall thickness at end-diastole 11	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	mr_raps	9	-0.65	0.10	3.65E-10	0.33	rs12453217,rs2070458,rs2696524,rs3803405,rs4965428,rs57610221,rs61775418,rs62253182,rs730506
regional myocardial-wall thickness at end-diastole 11	Other heart diseases	IX Diseases of the circulatory system (I9_)	MR Egger	9	0.01	0.47	9.85E-01	0.59	rs12453217,rs2070458,rs2696524,rs3803405,rs4965428,rs57610221,rs61775418,rs62253182,rs730506
regional myocardial-wall thickness at end-diastole 11	Other heart diseases	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (fixed effects)	9	-0.25	0.05	2.42E-06	0.59	rs12453217,rs2070458,rs2696524,rs3803405,rs4965428,rs57610221,rs61775418,rs62253182,rs730506
regional myocardial-wall thickness at end-diastole 11	Other heart diseases	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (multiplicative random effects)	9	-0.25	0.09	7.55E-03	0.59	rs12453217,rs2070458,rs2696524,rs3803405,rs4965428,rs57610221,rs61775418,rs62253182,rs730506
regional myocardial-wall thickness at end-diastole 11	Other heart diseases	IX Diseases of the circulatory system (I9_)	Weighted mode	9	-0.29	0.10	2.14E-02	0.59	rs12453217,rs2070458,rs2696524,rs3803405,rs4965428,rs57610221,rs61775418,rs62253182,rs730506
regional myocardial-wall thickness at end-diastole 11	Other heart diseases	IX Diseases of the circulatory system (I9_)	Weighted median	9	-0.26	0.08	5.24E-04	0.59	rs12453217,rs2070458,rs2696524,rs3803405,rs4965428,rs57610221,rs61775418,rs62253182,rs730506
regional myocardial-wall thickness at end-diastole 11	Other heart diseases	IX Diseases of the circulatory system (I9_)	DIVW	9	-0.26	0.06	2.27E-06	0.59	rs12453217,rs2070458,rs2696524,rs3803405,rs4965428,rs57610221,rs61775418,rs62253182,rs730506
regional myocardial-wall thickness at end-diastole 11	Other heart diseases	IX Diseases of the circulatory system (I9_)	GRAPPLE	9	-0.24	0.11	2.46E-02	0.59	rs12453217,rs2070458,rs2696524,rs3803405,rs4965428,rs57610221,rs61775418,rs62253182,rs730506
regional myocardial-wall thickness at end-diastole 11	Other heart diseases	IX Diseases of the circulatory system (I9_)	mr_raps	9	-0.30	0.06	1.35E-07	0.59	rs12453217,rs2070458,rs2696524,rs3803405,rs4965428,rs57610221,rs61775418,rs62253182,rs730506
regional myocardial-wall thickness at end-diastole 12	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	MR Egger	9	-0.19	0.87	8.31E-01	0.70	rs1004243,rs2732685,rs2952152,rs3803405,rs61775418,rs62253179,rs7112154,rs7166287,rs730506
regional myocardial-wall thickness at end-diastole 12	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (fixed effects)	9	-0.53	0.09	1.17E-08	0.70	rs1004243,rs2732685,rs2952152,rs3803405,rs61775418,rs62253179,rs7112154,rs7166287,rs730506
regional myocardial-wall thickness at end-diastole 12	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (multiplicative random effects)	9	-0.53	0.22	1.45E-02	0.70	rs1004243,rs2732685,rs2952152,rs3803405,rs61775418,rs62253179,rs7112154,rs7166287,rs730506
regional myocardial-wall thickness at end-diastole 12	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	Weighted mode	9	-0.40	0.14	2.14E-02	0.70	rs1004243,rs2732685,rs2952152,rs3803405,rs61775418,rs62253179,rs7112154,rs7166287,rs730506
regional myocardial-wall thickness at end-diastole 12	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	Weighted median	9	-0.41	0.14	3.02E-03	0.70	rs1004243,rs2732685,rs2952152,rs3803405,rs61775418,rs62253179,rs7112154,rs7166287,rs730506
regional myocardial-wall thickness at end-diastole 12	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	DIVW	9	-0.54	0.10	1.95E-08	0.70	rs1004243,rs2732685,rs2952152,rs3803405,rs61775418,rs62253179,rs7112154,rs7166287,rs730506
regional myocardial-wall thickness at end-diastole 12	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	GRAPPLE	9	-0.49	0.26	5.63E-02	0.70	rs1004243,rs2732685,rs2952152,rs3803405,rs61775418,rs62253179,rs7112154,rs7166287,rs730506
regional myocardial-wall thickness at end-diastole 12	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	mr_raps	9	-0.55	0.10	1.98E-08	0.70	rs1004243,rs2732685,rs2952152,rs3803405,rs61775418,rs62253179,rs7112154,rs7166287,rs730506
regional myocardial-wall thickness at end-diastole 12	Other heart diseases	IX Diseases of the circulatory system (I9_)	MR Egger	9	-0.36	0.35	3.43E-01	0.75	rs1004243,rs2732685,rs2952152,rs3803405,rs61775418,rs62253179,rs7112154,rs7166287,rs730506
regional myocardial-wall thickness at end-diastole 12	Other heart diseases	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (fixed effects)	9	-0.24	0.05	1.55E-06	0.75	rs1004243,rs2732685,rs2952152,rs3803405,rs61775418,rs62253179,rs7112154,rs7166287,rs730506
regional myocardial-wall thickness at end-diastole 12	Other heart diseases	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (multiplicative random effects)	9	-0.24	0.09	5.12E-03	0.75	rs1004243,rs2732685,rs2952152,rs3803405,rs61775418,rs62253179,rs7112154,rs7166287,rs730506
regional myocardial-wall thickness at end-diastole 12	Other heart diseases	IX Diseases of the circulatory system (I9_)	Weighted mode	9	-0.27	0.09	1.40E-02	0.75	rs1004243,rs2732685,rs2952152,rs3803405,rs61775418,rs62253179,rs7112154,rs7166287,rs730506
regional myocardial-wall thickness at end-diastole 12	Other heart diseases	IX Diseases of the circulatory system (I9_)	Weighted median	9	-0.25	0.07	3.97E-04	0.75	rs1004243,rs2732685,rs2952152,rs3803405,rs61775418,rs62253179,rs7112154,rs7166287,rs730506
regional myocardial-wall thickness at end-diastole 12	Other heart diseases	IX Diseases of the circulatory system (I9_)	DIVW	9	-0.25	0.05	1.46E-06	0.75	rs1004243,rs2732685,rs2952152,rs3803405,rs61775418,rs62253179,rs7112154,rs7166287,rs730506
regional myocardial-wall thickness at end-diastole 12	Other heart diseases	IX Diseases of the circulatory system (I9_)	GRAPPLE	9	-0.23	0.10	2.16E-02	0.75	rs1004243,rs2732685,rs2952152,rs3803405,rs61775418,rs62253179,rs7112154,rs7166287,rs730506
regional myocardial-wall thickness at end-diastole 12	Other heart diseases	IX Diseases of the circulatory system (I9_)	mr_raps	9	-0.26	0.05	1.47E-06	0.75	rs1004243,rs2732685,rs2952152,rs3803405,rs61775418,rs62253179,rs7112154,rs7166287,rs730506
regional myocardial-wall thickness at end-diastole 16	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	MR Egger	6	1.06	2.68	7.14E-01	0.52	rs2255167,rs2798321,rs35808647,rs4965430,rs62062271,rs7354918
regional myocardial-wall thickness at end-diastole 16	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (fixed effects)	6	-0.80	0.12	5.04E-12	0.52	rs2255167,rs2798321,rs35808647,rs4965430,rs62062271,rs7354918
regional myocardial-wall thickness at end-diastole 16	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (multiplicative random effects)	6	-0.80	0.36	2.73E-02	0.52	rs2255167,rs2798321,rs35808647,rs4965430,rs62062271,rs7354918
regional myocardial-wall thickness at end-diastole 16	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	Weighted mode	6	-0.71	0.19	1.24E-02	0.52	rs2255167,rs2798321,rs35808647,rs4965430,rs62062271,rs7354918
regional myocardial-wall thickness at end-diastole 16	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	Weighted median	6	-0.70	0.18	9.70E-05	0.52	rs2255167,rs2798321,rs35808647,rs4965430,rs62062271,rs7354918
regional myocardial-wall thickness at end-diastole 16	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	DIVW	6	-0.82	0.13	1.48E-10	0.52	rs2255167,rs2798321,rs35808647,rs4965430,rs62062271,rs7354918
regional myocardial-wall thickness at end-diastole 16	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	GRAPPLE	6	-0.73	0.45	1.04E-01	0.52	rs2255167,rs2798321,rs35808647,rs4965430,rs62062271,rs7354918
regional myocardial-wall thickness at end-diastole 16	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	mr_raps	6	-0.85	0.13	9.72E-12	0.52	rs2255167,rs2798321,rs35808647,rs4965430,rs62062271,rs7354918
regional myocardial-wall thickness at end-diastole 16	Hypertension	IX Diseases of the circulatory system (I9_)	MR Egger	6	-0.37	0.72	6.31E-01	0.99	rs2255167,rs2798321,rs35808647,rs4965430,rs62062271,rs7354918
regional myocardial-wall thickness at end-diastole 16	Hypertension	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (fixed effects)	6	-0.38	0.07	1.85E-08	0.99	rs2255167,rs2798321,rs35808647,rs4965430,rs62062271,rs7354918
regional myocardial-wall thickness at end-diastole 16	Hypertension	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (multiplicative random effects)	6	-0.38	0.09	3.52E-05	0.99	rs2255167,rs2798321,rs35808647,rs4965430,rs62062271,rs7354918
regional myocardial-wall thickness at end-diastole 16	Hypertension	IX Diseases of the circulatory system (I9_)	Weighted mode	6	-0.23	0.12	1.22E-01	0.99	rs2255167,rs2798321,rs35808647,rs4965430,rs62062271,rs7354918
regional myocardial-wall thickness at end-diastole 16	Hypertension	IX Diseases of the circulatory system (I9_)	Weighted median	6	-0.25	0.10	9.66E-03	0.99	rs2255167,rs2798321,rs35808647,rs4965430,rs62062271,rs7354918
regional myocardial-wall thickness at end-diastole 16	Hypertension	IX Diseases of the circulatory system (I9_)	DIVW	6	-0.39	0.07	6.32E-08	0.99	rs2255167,rs2798321,rs35808647,rs4965430,rs62062271,rs7354918
regional myocardial-wall thickness at end-diastole 16	Hypertension	IX Diseases of the circulatory system (I9_)	GRAPPLE	6	-0.38	0.10	1.22E-04	0.99	rs2255167,rs2798321,rs35808647,rs4965430,rs62062271,rs7354918
regional myocardial-wall thickness at end-diastole 16	Hypertension	IX Diseases of the circulatory system (I9_)	mr_raps	6	-0.37	0.07	5.34E-07	0.99	rs2255167,rs2798321,rs35808647,rs4965430,rs62062271,rs7354918
regional myocardial-wall thickness at end-diastole 16	Other heart diseases	IX Diseases of the circulatory system (I9_)	MR Egger	6	0.33	1.01	7.61E-01	0.56	rs2255167,rs2798321,rs35808647,rs4965430,rs62062271,rs7354918
regional myocardial-wall thickness at end-diastole 16	Other heart diseases	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (fixed effects)	6	-0.31	0.06	1.18E-06	0.56	rs2255167,rs2798321,rs35808647,rs4965430,rs62062271,rs7354918
regional myocardial-wall thickness at end-diastole 16	Other heart diseases	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (multiplicative random effects)	6	-0.31	0.14	2.28E-02	0.56	rs2255167,rs2798321,rs35808647,rs4965430,rs62062271,rs7354918
regional myocardial-wall thickness at end-diastole 16	Other heart diseases	IX Diseases of the circulatory system (I9_)	Weighted mode	6	-0.34	0.14	6.02E-02	0.56	rs2255167,rs2798321,rs35808647,rs4965430,rs62062271,rs7354918
regional myocardial-wall thickness at end-diastole 16	Other heart diseases	IX Diseases of the circulatory system (I9_)	Weighted median	6	-0.31	0.10	1.85E-03	0.56	rs2255167,rs2798321,rs35808647,rs4965430,rs62062271,rs7354918
regional myocardial-wall thickness at end-diastole 16	Other heart diseases	IX Diseases of the circulatory system (I9_)	DIVW	6	-0.32	0.07	1.79E-06	0.56	rs2255167,rs2798321,rs35808647,rs4965430,rs62062271,rs7354918
regional myocardial-wall thickness at end-diastole 16	Other heart diseases	IX Diseases of the circulatory system (I9_)	GRAPPLE	6	-0.30	0.16	6.51E-02	0.56	rs2255167,rs2798321,rs35808647,rs4965430,rs62062271,rs7354918
regional myocardial-wall thickness at end-diastole 16	Other heart diseases	IX Diseases of the circulatory system (I9_)	mr_raps	6	-0.37	0.07	1.24E-07	0.56	rs2255167,rs2798321,rs35808647,rs4965430,rs62062271,rs7354918
right ventricular ejection fraction	Other heart diseases	Cardiometabolic endpoints	MR Egger	12	0.25	0.18	2.01E-01	0.03	rs11786896,rs17617337,rs1915986,rs2009371,rs2137537,rs2789750,rs2848901,rs3738685,rs3813243,rs422068,rs7613814,rs7650482
right ventricular ejection fraction	Other heart diseases	Cardiometabolic endpoints	Inverse variance weighted (fixed effects)	12	-0.21	0.05	6.18E-06	0.03	rs11786896,rs17617337,rs1915986,rs2009371,rs2137537,rs2789750,rs2848901,rs3738685,rs3813243,rs422068,rs7613814,rs7650482
right ventricular ejection fraction	Other heart diseases	Cardiometabolic endpoints	Inverse variance weighted (multiplicative random effects)	12	-0.21	0.06	6.87E-04	0.03	rs11786896,rs17617337,rs1915986,rs2009371,rs2137537,rs2789750,rs2848901,rs3738685,rs3813243,rs422068,rs7613814,rs7650482
right ventricular ejection fraction	Other heart diseases	Cardiometabolic endpoints	Weighted mode	12	-0.08	0.10	3.95E-01	0.03	rs11786896,rs17617337,rs1915986,rs2009371,rs2137537,rs2789750,rs2848901,rs3738685,rs3813243,rs422068,rs7613814,rs7650482
right ventricular ejection fraction	Other heart diseases	Cardiometabolic endpoints	Weighted median	12	-0.09	0.07	1.70E-01	0.03	rs11786896,rs17617337,rs1915986,rs2009371,rs2137537,rs2789750,rs2848901,rs3738685,rs3813243,rs422068,rs7613814,rs7650482
right ventricular ejection fraction	Other heart diseases	Cardiometabolic endpoints	DIVW	12	-0.21	0.05	5.08E-06	0.03	rs11786896,rs17617337,rs1915986,rs2009371,rs2137537,rs2789750,rs2848901,rs3738685,rs3813243,rs422068,rs7613814,rs7650482
right ventricular ejection fraction	Other heart diseases	Cardiometabolic endpoints	GRAPPLE	12	-0.18	0.07	5.85E-03	0.03	rs11786896,rs17617337,rs1915986,rs2009371,rs2137537,rs2789750,rs2848901,rs3738685,rs3813243,rs422068,rs7613814,rs7650482
right ventricular ejection fraction	Other heart diseases	Cardiometabolic endpoints	mr_raps	12	-0.19	0.05	6.98E-05	0.03	rs11786896,rs17617337,rs1915986,rs2009371,rs2137537,rs2789750,rs2848901,rs3738685,rs3813243,rs422068,rs7613814,rs7650482
right ventricular ejection fraction	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	MR Egger	12	1.08	0.55	7.85E-02	0.02	rs11786896,rs17617337,rs1915986,rs2009371,rs2137537,rs2789750,rs2848901,rs3738685,rs3813243,rs422068,rs7613814,rs7650482
right ventricular ejection fraction	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (fixed effects)	12	-0.44	0.07	7.99E-10	0.02	rs11786896,rs17617337,rs1915986,rs2009371,rs2137537,rs2789750,rs2848901,rs3738685,rs3813243,rs422068,rs7613814,rs7650482
right ventricular ejection fraction	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	Inverse variance weighted (multiplicative random effects)	12	-0.44	0.19	2.21E-02	0.02	rs11786896,rs17617337,rs1915986,rs2009371,rs2137537,rs2789750,rs2848901,rs3738685,rs3813243,rs422068,rs7613814,rs7650482
right ventricular ejection fraction	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	Weighted mode	12	-0.13	0.13	3.39E-01	0.02	rs11786896,rs17617337,rs1915986,rs2009371,rs2137537,rs2789750,rs2848901,rs3738685,rs3813243,rs422068,rs7613814,rs7650482
right ventricular ejection fraction	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	Weighted median	12	-0.24	0.12	4.50E-02	0.02	rs11786896,rs17617337,rs1915986,rs2009371,rs2137537,rs2789750,rs2848901,rs3738685,rs3813243,rs422068,rs7613814,rs7650482
right ventricular ejection fraction	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	DIVW	12	-0.45	0.08	1.99E-09	0.02	rs11786896,rs17617337,rs1915986,rs2009371,rs2137537,rs2789750,rs2848901,rs3738685,rs3813243,rs422068,rs7613814,rs7650482
right ventricular ejection fraction	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	GRAPPLE	12	-0.15	0.20	4.39E-01	0.02	rs11786896,rs17617337,rs1915986,rs2009371,rs2137537,rs2789750,rs2848901,rs3738685,rs3813243,rs422068,rs7613814,rs7650482
right ventricular ejection fraction	Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	mr_raps	12	-0.37	0.07	2.25E-07	0.02	rs11786896,rs17617337,rs1915986,rs2009371,rs2137537,rs2789750,rs2848901,rs3738685,rs3813243,rs422068,rs7613814,rs7650482
right ventricular ejection fraction	Heart failure and antihypertensive medication	Cardiometabolic endpoints	MR Egger	12	-0.21	0.57	7.19E-01	0.66	rs11786896,rs17617337,rs1915986,rs2009371,rs2137537,rs2789750,rs2848901,rs3738685,rs3813243,rs422068,rs7613814,rs7650482
right ventricular ejection fraction	Heart failure and antihypertensive medication	Cardiometabolic endpoints	Inverse variance weighted (fixed effects)	12	-0.46	0.09	2.26E-07	0.66	rs11786896,rs17617337,rs1915986,rs2009371,rs2137537,rs2789750,rs2848901,rs3738685,rs3813243,rs422068,rs7613814,rs7650482
right ventricular ejection fraction	Heart failure and antihypertensive medication	Cardiometabolic endpoints	Inverse variance weighted (multiplicative random effects)	12	-0.46	0.15	1.68E-03	0.66	rs11786896,rs17617337,rs1915986,rs2009371,rs2137537,rs2789750,rs2848901,rs3738685,rs3813243,rs422068,rs7613814,rs7650482
right ventricular ejection fraction	Heart failure and antihypertensive medication	Cardiometabolic endpoints	Weighted mode	12	-0.17	0.30	5.88E-01	0.66	rs11786896,rs17617337,rs1915986,rs2009371,rs2137537,rs2789750,rs2848901,rs3738685,rs3813243,rs422068,rs7613814,rs7650482
right ventricular ejection fraction	Heart failure and antihypertensive medication	Cardiometabolic endpoints	Weighted median	12	-0.34	0.15	2.25E-02	0.66	rs11786896,rs17617337,rs1915986,rs2009371,rs2137537,rs2789750,rs2848901,rs3738685,rs3813243,rs422068,rs7613814,rs7650482
right ventricular ejection fraction	Heart failure and antihypertensive medication	Cardiometabolic endpoints	DIVW	12	-0.47	0.09	2.61E-07	0.66	rs11786896,rs17617337,rs1915986,rs2009371,rs2137537,rs2789750,rs2848901,rs3738685,rs3813243,rs422068,rs7613814,rs7650482
right ventricular ejection fraction	Heart failure and antihypertensive medication	Cardiometabolic endpoints	GRAPPLE	12	-0.41	0.16	1.05E-02	0.66	rs11786896,rs17617337,rs1915986,rs2009371,rs2137537,rs2789750,rs2848901,rs3738685,rs3813243,rs422068,rs7613814,rs7650482
right ventricular ejection fraction	Heart failure and antihypertensive medication	Cardiometabolic endpoints	mr_raps	12	-0.45	0.09	1.78E-06	0.66	rs11786896,rs17617337,rs1915986,rs2009371,rs2137537,rs2789750,rs2848901,rs3738685,rs3813243,rs422068,rs7613814,rs7650482
right ventricular end-systolic volume	Autoimmune diseases	Diseases marked as autimmune origin	MR Egger	17	-0.32	0.88	7.20E-01	0.88	rs10167919,rs11786896,rs12996582,rs17608766,rs17617337,rs2042995,rs2066333,rs2848918,rs3738685,rs379824,rs55834511,rs653178,rs7799311,rs80197559,rs8132085,rs9442217,rs9844502
right ventricular end-systolic volume	Autoimmune diseases	Diseases marked as autimmune origin	Inverse variance weighted (fixed effects)	17	-0.18	0.04	3.10E-06	0.88	rs10167919,rs11786896,rs12996582,rs17608766,rs17617337,rs2042995,rs2066333,rs2848918,rs3738685,rs379824,rs55834511,rs653178,rs7799311,rs80197559,rs8132085,rs9442217,rs9844502
right ventricular end-systolic volume	Autoimmune diseases	Diseases marked as autimmune origin	Inverse variance weighted (multiplicative random effects)	17	-0.18	0.19	3.40E-01	0.88	rs10167919,rs11786896,rs12996582,rs17608766,rs17617337,rs2042995,rs2066333,rs2848918,rs3738685,rs379824,rs55834511,rs653178,rs7799311,rs80197559,rs8132085,rs9442217,rs9844502
right ventricular end-systolic volume	Autoimmune diseases	Diseases marked as autimmune origin	Weighted mode	17	0.14	0.10	2.00E-01	0.88	rs10167919,rs11786896,rs12996582,rs17608766,rs17617337,rs2042995,rs2066333,rs2848918,rs3738685,rs379824,rs55834511,rs653178,rs7799311,rs80197559,rs8132085,rs9442217,rs9844502
right ventricular end-systolic volume	Autoimmune diseases	Diseases marked as autimmune origin	Weighted median	17	0.09	0.06	1.43E-01	0.88	rs10167919,rs11786896,rs12996582,rs17608766,rs17617337,rs2042995,rs2066333,rs2848918,rs3738685,rs379824,rs55834511,rs653178,rs7799311,rs80197559,rs8132085,rs9442217,rs9844502
right ventricular end-systolic volume	Autoimmune diseases	Diseases marked as autimmune origin	DIVW	17	-0.19	0.04	2.22E-06	0.88	rs10167919,rs11786896,rs12996582,rs17608766,rs17617337,rs2042995,rs2066333,rs2848918,rs3738685,rs379824,rs55834511,rs653178,rs7799311,rs80197559,rs8132085,rs9442217,rs9844502
right ventricular end-systolic volume	Autoimmune diseases	Diseases marked as autimmune origin	GRAPPLE	17	0.07	0.07	3.52E-01	0.88	rs10167919,rs11786896,rs12996582,rs17608766,rs17617337,rs2042995,rs2066333,rs2848918,rs3738685,rs379824,rs55834511,rs653178,rs7799311,rs80197559,rs8132085,rs9442217,rs9844502
right ventricular end-systolic volume	Autoimmune diseases	Diseases marked as autimmune origin	mr_raps	17	0.04	0.03	1.94E-01	0.88	rs10167919,rs11786896,rs12996582,rs17608766,rs17617337,rs2042995,rs2066333,rs2848918,rs3738685,rs379824,rs55834511,rs653178,rs7799311,rs80197559,rs8132085,rs9442217,rs9844502
right ventricular end-systolic volume	Heart failure and antihypertensive medication	Cardiometabolic endpoints	MR Egger	17	0.80	1.09	4.72E-01	0.77	rs10167919,rs11786896,rs12996582,rs17608766,rs17617337,rs2042995,rs2066333,rs2848918,rs3738685,rs379824,rs55834511,rs653178,rs7799311,rs80197559,rs8132085,rs9442217,rs9844502
right ventricular end-systolic volume	Heart failure and antihypertensive medication	Cardiometabolic endpoints	Inverse variance weighted (fixed effects)	17	0.49	0.09	5.32E-08	0.77	rs10167919,rs11786896,rs12996582,rs17608766,rs17617337,rs2042995,rs2066333,rs2848918,rs3738685,rs379824,rs55834511,rs653178,rs7799311,rs80197559,rs8132085,rs9442217,rs9844502
right ventricular end-systolic volume	Heart failure and antihypertensive medication	Cardiometabolic endpoints	Inverse variance weighted (multiplicative random effects)	17	0.49	0.24	4.07E-02	0.77	rs10167919,rs11786896,rs12996582,rs17608766,rs17617337,rs2042995,rs2066333,rs2848918,rs3738685,rs379824,rs55834511,rs653178,rs7799311,rs80197559,rs8132085,rs9442217,rs9844502
right ventricular end-systolic volume	Heart failure and antihypertensive medication	Cardiometabolic endpoints	Weighted mode	17	0.53	0.27	6.58E-02	0.77	rs10167919,rs11786896,rs12996582,rs17608766,rs17617337,rs2042995,rs2066333,rs2848918,rs3738685,rs379824,rs55834511,rs653178,rs7799311,rs80197559,rs8132085,rs9442217,rs9844502
right ventricular end-systolic volume	Heart failure and antihypertensive medication	Cardiometabolic endpoints	Weighted median	17	0.55	0.15	3.31E-04	0.77	rs10167919,rs11786896,rs12996582,rs17608766,rs17617337,rs2042995,rs2066333,rs2848918,rs3738685,rs379824,rs55834511,rs653178,rs7799311,rs80197559,rs8132085,rs9442217,rs9844502
right ventricular end-systolic volume	Heart failure and antihypertensive medication	Cardiometabolic endpoints	DIVW	17	0.50	0.09	5.12E-08	0.77	rs10167919,rs11786896,rs12996582,rs17608766,rs17617337,rs2042995,rs2066333,rs2848918,rs3738685,rs379824,rs55834511,rs653178,rs7799311,rs80197559,rs8132085,rs9442217,rs9844502
right ventricular end-systolic volume	Heart failure and antihypertensive medication	Cardiometabolic endpoints	GRAPPLE	17	0.62	0.22	5.21E-03	0.77	rs10167919,rs11786896,rs12996582,rs17608766,rs17617337,rs2042995,rs2066333,rs2848918,rs3738685,rs379824,rs55834511,rs653178,rs7799311,rs80197559,rs8132085,rs9442217,rs9844502
right ventricular end-systolic volume	Heart failure and antihypertensive medication	Cardiometabolic endpoints	mr_raps	17	0.71	0.09	6.13E-14	0.77	rs10167919,rs11786896,rs12996582,rs17608766,rs17617337,rs2042995,rs2066333,rs2848918,rs3738685,rs379824,rs55834511,rs653178,rs7799311,rs80197559,rs8132085,rs9442217,rs9844502

id.exposure	exp.category	id.outcome	method	nsnp	b	se	pval	MR-Egger intercept Pvalue	snps
COPD, hospital admissions	COPD and related endpoints	descending aorta maximum area	MR Egger	7	0.10	0.07	2.08E-01	0.94	rs11083581,rs113623975,rs2273500,rs28929474,rs2921096,rs3129967,rs8040868
COPD, hospital admissions	COPD and related endpoints	descending aorta maximum area	Inverse variance weighted (fixed effects)	7	0.10	0.02	5.29E-06	0.94	rs11083581,rs113623975,rs2273500,rs28929474,rs2921096,rs3129967,rs8040868
COPD, hospital admissions	COPD and related endpoints	descending aorta maximum area	Inverse variance weighted (multiplicative random effects)	7	0.10	0.03	1.25E-04	0.94	rs11083581,rs113623975,rs2273500,rs28929474,rs2921096,rs3129967,rs8040868
COPD, hospital admissions	COPD and related endpoints	descending aorta maximum area	Weighted mode	7	0.09	0.03	2.34E-02	0.94	rs11083581,rs113623975,rs2273500,rs28929474,rs2921096,rs3129967,rs8040868
COPD, hospital admissions	COPD and related endpoints	descending aorta maximum area	Weighted median	7	0.10	0.03	4.00E-04	0.94	rs11083581,rs113623975,rs2273500,rs28929474,rs2921096,rs3129967,rs8040868
COPD, hospital admissions	COPD and related endpoints	descending aorta maximum area	DIVW	7	0.10	0.02	4.45E-06	0.94	rs11083581,rs113623975,rs2273500,rs28929474,rs2921096,rs3129967,rs8040868
COPD, hospital admissions	COPD and related endpoints	descending aorta maximum area	GRAPPLE	7	0.10	0.03	2.89E-04	0.94	rs11083581,rs113623975,rs2273500,rs28929474,rs2921096,rs3129967,rs8040868
COPD, hospital admissions	COPD and related endpoints	descending aorta maximum area	mr_raps	7	0.10	0.02	1.26E-05	0.94	rs11083581,rs113623975,rs2273500,rs28929474,rs2921096,rs3129967,rs8040868
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	ascending aorta distensibility	MR Egger	111	-0.13	0.06	3.20E-02	0.83	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	ascending aorta distensibility	Inverse variance weighted (fixed effects)	111	-0.11	0.01	1.44E-17	0.83	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	ascending aorta distensibility	Inverse variance weighted (multiplicative random effects)	111	-0.11	0.02	9.29E-13	0.83	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	ascending aorta distensibility	Weighted mode	111	-0.15	0.05	5.90E-03	0.83	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	ascending aorta distensibility	Weighted median	111	-0.12	0.02	1.98E-09	0.83	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	ascending aorta distensibility	DIVW	111	-0.12	0.01	0.00E+00	0.83	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	ascending aorta distensibility	GRAPPLE	111	-0.11	0.02	5.13E-12	0.83	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	ascending aorta distensibility	mr_raps	111	-0.12	0.01	2.22E-16	0.83	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	ascending aorta maximum area	MR Egger	111	0.10	0.08	2.01E-01	0.94	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	ascending aorta maximum area	Inverse variance weighted (fixed effects)	111	0.10	0.01	5.02E-13	0.94	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	ascending aorta maximum area	Inverse variance weighted (multiplicative random effects)	111	0.10	0.02	1.07E-05	0.94	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	ascending aorta maximum area	Weighted mode	111	-0.01	0.11	9.56E-01	0.94	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	ascending aorta maximum area	Weighted median	111	0.08	0.02	1.14E-03	0.94	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	ascending aorta maximum area	DIVW	111	0.10	0.01	3.34E-13	0.94	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	ascending aorta maximum area	GRAPPLE	111	0.09	0.02	5.47E-05	0.94	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	ascending aorta maximum area	mr_raps	111	0.09	0.01	1.27E-11	0.94	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	ascending aorta minimum area	MR Egger	111	0.12	0.08	1.40E-01	0.82	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	ascending aorta minimum area	Inverse variance weighted (fixed effects)	111	0.10	0.01	2.06E-14	0.82	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	ascending aorta minimum area	Inverse variance weighted (multiplicative random effects)	111	0.10	0.02	3.87E-06	0.82	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	ascending aorta minimum area	Weighted mode	111	-0.01	0.11	9.21E-01	0.82	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	ascending aorta minimum area	Weighted median	111	0.09	0.02	3.03E-04	0.82	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	ascending aorta minimum area	DIVW	111	0.10	0.01	1.48E-14	0.82	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	ascending aorta minimum area	GRAPPLE	111	0.09	0.02	2.18E-05	0.82	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	ascending aorta minimum area	mr_raps	111	0.10	0.01	1.85E-12	0.82	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	descending aorta distensibility	MR Egger	111	-0.12	0.06	4.18E-02	0.93	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	descending aorta distensibility	Inverse variance weighted (fixed effects)	111	-0.12	0.01	1.69E-17	0.93	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	descending aorta distensibility	Inverse variance weighted (multiplicative random effects)	111	-0.12	0.02	6.74E-13	0.93	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	descending aorta distensibility	Weighted mode	111	-0.12	0.05	1.77E-02	0.93	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	descending aorta distensibility	Weighted median	111	-0.11	0.02	1.26E-07	0.93	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	descending aorta distensibility	DIVW	111	-0.12	0.01	0.00E+00	0.93	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	descending aorta distensibility	GRAPPLE	111	-0.11	0.02	1.55E-11	0.93	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	descending aorta distensibility	mr_raps	111	-0.11	0.01	2.00E-15	0.93	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	descending aorta maximum area	MR Egger	111	0.06	0.07	4.17E-01	0.94	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	descending aorta maximum area	Inverse variance weighted (fixed effects)	111	0.06	0.01	2.16E-07	0.94	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	descending aorta maximum area	Inverse variance weighted (multiplicative random effects)	111	0.06	0.02	1.32E-03	0.94	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	descending aorta maximum area	Weighted mode	111	-0.01	0.07	9.22E-01	0.94	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	descending aorta maximum area	Weighted median	111	0.03	0.02	9.46E-02	0.94	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	descending aorta maximum area	DIVW	111	0.06	0.01	1.17E-07	0.94	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	descending aorta maximum area	GRAPPLE	111	0.05	0.02	8.46E-03	0.94	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	descending aorta maximum area	mr_raps	111	0.05	0.01	1.25E-05	0.94	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	descending aorta minimum area	MR Egger	111	0.06	0.07	3.75E-01	0.97	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	descending aorta minimum area	Inverse variance weighted (fixed effects)	111	0.06	0.01	3.73E-08	0.97	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	descending aorta minimum area	Inverse variance weighted (multiplicative random effects)	111	0.06	0.02	7.68E-04	0.97	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	descending aorta minimum area	Weighted mode	111	0.01	0.07	8.62E-01	0.97	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	descending aorta minimum area	Weighted median	111	0.05	0.02	9.10E-03	0.97	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	descending aorta minimum area	DIVW	111	0.06	0.01	2.06E-08	0.97	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	descending aorta minimum area	GRAPPLE	111	0.06	0.02	2.54E-03	0.97	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	descending aorta minimum area	mr_raps	111	0.06	0.01	1.97E-07	0.97	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	global myocardial-wall thickness at end-diastole	MR Egger	111	0.24	0.05	2.21E-05	0.06	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	global myocardial-wall thickness at end-diastole	Inverse variance weighted (fixed effects)	111	0.14	0.01	8.21E-43	0.06	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	global myocardial-wall thickness at end-diastole	Inverse variance weighted (multiplicative random effects)	111	0.14	0.02	9.51E-21	0.06	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	global myocardial-wall thickness at end-diastole	Weighted mode	111	0.16	0.07	1.75E-02	0.06	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	global myocardial-wall thickness at end-diastole	Weighted median	111	0.15	0.02	4.76E-18	0.06	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	global myocardial-wall thickness at end-diastole	DIVW	111	0.14	0.01	0.00E+00	0.06	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	global myocardial-wall thickness at end-diastole	GRAPPLE	111	0.15	0.02	1.84E-21	0.06	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	global myocardial-wall thickness at end-diastole	mr_raps	111	0.15	0.01	0.00E+00	0.06	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	global radial strain	MR Egger	111	0.11	0.06	5.57E-02	0.82	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	global radial strain	Inverse variance weighted (fixed effects)	111	0.10	0.01	1.95E-13	0.82	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	global radial strain	Inverse variance weighted (multiplicative random effects)	111	0.10	0.02	4.86E-10	0.82	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	global radial strain	Weighted mode	111	0.06	0.05	2.39E-01	0.82	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	global radial strain	Weighted median	111	0.09	0.02	2.42E-05	0.82	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	global radial strain	DIVW	111	0.10	0.01	1.32E-13	0.82	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	global radial strain	GRAPPLE	111	0.10	0.02	4.47E-09	0.82	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	global radial strain	mr_raps	111	0.10	0.01	5.44E-12	0.82	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left atrium maximum volume	MR Egger	111	0.02	0.06	8.07E-01	0.21	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left atrium maximum volume	Inverse variance weighted (fixed effects)	111	0.09	0.01	8.06E-11	0.21	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left atrium maximum volume	Inverse variance weighted (multiplicative random effects)	111	0.09	0.02	1.34E-07	0.21	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left atrium maximum volume	Weighted mode	111	0.09	0.05	5.27E-02	0.21	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left atrium maximum volume	Weighted median	111	0.09	0.02	4.90E-05	0.21	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left atrium maximum volume	DIVW	111	0.09	0.01	4.86E-11	0.21	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left atrium maximum volume	GRAPPLE	111	0.09	0.02	8.56E-07	0.21	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left atrium maximum volume	mr_raps	111	0.09	0.01	9.87E-11	0.21	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left atrium minimum volume	MR Egger	111	0.04	0.06	4.89E-01	0.32	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left atrium minimum volume	Inverse variance weighted (fixed effects)	111	0.09	0.01	8.90E-11	0.32	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left atrium minimum volume	Inverse variance weighted (multiplicative random effects)	111	0.09	0.02	2.35E-09	0.32	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left atrium minimum volume	Weighted mode	111	0.07	0.05	1.40E-01	0.32	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left atrium minimum volume	Weighted median	111	0.09	0.02	1.64E-04	0.32	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left atrium minimum volume	DIVW	111	0.10	0.01	5.36E-11	0.32	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left atrium minimum volume	GRAPPLE	111	0.09	0.02	2.08E-08	0.32	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left atrium minimum volume	mr_raps	111	0.09	0.02	1.08E-09	0.32	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left atrium stroke volume	MR Egger	111	0.02	0.07	7.66E-01	0.37	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left atrium stroke volume	Inverse variance weighted (fixed effects)	111	0.08	0.01	3.04E-08	0.37	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left atrium stroke volume	Inverse variance weighted (multiplicative random effects)	111	0.08	0.02	2.64E-05	0.37	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left atrium stroke volume	Weighted mode	111	0.10	0.05	4.78E-02	0.37	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left atrium stroke volume	Weighted median	111	0.08	0.02	1.88E-04	0.37	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left atrium stroke volume	DIVW	111	0.08	0.01	1.68E-08	0.37	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left atrium stroke volume	GRAPPLE	111	0.08	0.02	2.42E-05	0.37	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left atrium stroke volume	mr_raps	111	0.09	0.01	1.76E-09	0.37	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular cardiac output	MR Egger	111	-0.03	0.06	6.20E-01	0.14	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular cardiac output	Inverse variance weighted (fixed effects)	111	0.06	0.01	9.68E-06	0.14	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular cardiac output	Inverse variance weighted (multiplicative random effects)	111	0.06	0.02	7.59E-04	0.14	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular cardiac output	Weighted mode	111	0.01	0.05	7.83E-01	0.14	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular cardiac output	Weighted median	111	0.05	0.02	3.02E-02	0.14	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular cardiac output	DIVW	111	0.06	0.01	5.04E-06	0.14	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular cardiac output	GRAPPLE	111	0.06	0.02	3.78E-04	0.14	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular cardiac output	mr_raps	111	0.06	0.01	3.16E-06	0.14	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular end-diastolic volume	MR Egger	111	-0.04	0.05	4.77E-01	0.09	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular end-diastolic volume	Inverse variance weighted (fixed effects)	111	0.05	0.01	1.11E-06	0.09	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular end-diastolic volume	Inverse variance weighted (multiplicative random effects)	111	0.05	0.02	6.32E-04	0.09	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular end-diastolic volume	Weighted mode	111	0.04	0.04	3.34E-01	0.09	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular end-diastolic volume	Weighted median	111	0.04	0.02	9.71E-03	0.09	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular end-diastolic volume	DIVW	111	0.05	0.01	5.88E-07	0.09	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular end-diastolic volume	GRAPPLE	111	0.05	0.02	6.57E-04	0.09	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular end-diastolic volume	mr_raps	111	0.05	0.01	2.79E-06	0.09	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular end-systolic volume	MR Egger	111	0.02	0.05	7.69E-01	0.47	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular end-systolic volume	Inverse variance weighted (fixed effects)	111	0.05	0.01	5.54E-06	0.47	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular end-systolic volume	Inverse variance weighted (multiplicative random effects)	111	0.05	0.01	3.50E-04	0.47	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular end-systolic volume	Weighted mode	111	0.07	0.05	1.34E-01	0.47	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular end-systolic volume	Weighted median	111	0.06	0.02	2.00E-03	0.47	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular end-systolic volume	DIVW	111	0.05	0.01	2.90E-06	0.47	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular end-systolic volume	GRAPPLE	111	0.06	0.02	2.51E-04	0.47	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular end-systolic volume	mr_raps	111	0.06	0.01	5.86E-07	0.47	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular myocardial mass	MR Egger	111	0.13	0.05	1.15E-02	0.80	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular myocardial mass	Inverse variance weighted (fixed effects)	111	0.11	0.01	2.40E-39	0.80	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular myocardial mass	Inverse variance weighted (multiplicative random effects)	111	0.11	0.01	3.06E-17	0.80	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular myocardial mass	Weighted mode	111	0.15	0.04	1.01E-03	0.80	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular myocardial mass	Weighted median	111	0.11	0.01	3.04E-15	0.80	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular myocardial mass	DIVW	111	0.12	0.01	0.00E+00	0.80	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular myocardial mass	GRAPPLE	111	0.12	0.01	8.62E-17	0.80	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	left ventricular myocardial mass	mr_raps	111	0.12	0.01	0.00E+00	0.80	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 1	MR Egger	111	0.23	0.06	2.41E-04	0.12	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 1	Inverse variance weighted (fixed effects)	111	0.14	0.01	4.82E-28	0.12	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 1	Inverse variance weighted (multiplicative random effects)	111	0.14	0.02	2.80E-16	0.12	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 1	Weighted mode	111	0.15	0.06	2.40E-02	0.12	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 1	Weighted median	111	0.14	0.02	2.05E-12	0.12	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 1	DIVW	111	0.14	0.01	0.00E+00	0.12	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 1	GRAPPLE	111	0.15	0.02	1.18E-16	0.12	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 1	mr_raps	111	0.15	0.01	0.00E+00	0.12	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 10	MR Egger	111	0.17	0.06	2.83E-03	0.42	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 10	Inverse variance weighted (fixed effects)	111	0.13	0.01	1.56E-33	0.42	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 10	Inverse variance weighted (multiplicative random effects)	111	0.13	0.02	1.38E-16	0.42	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 10	Weighted mode	111	0.07	0.05	1.61E-01	0.42	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 10	Weighted median	111	0.09	0.02	9.86E-09	0.42	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 10	DIVW	111	0.13	0.01	0.00E+00	0.42	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 10	GRAPPLE	111	0.12	0.02	8.45E-15	0.42	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 10	mr_raps	111	0.12	0.01	0.00E+00	0.42	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 11	MR Egger	111	0.19	0.05	2.33E-04	0.10	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 11	Inverse variance weighted (fixed effects)	111	0.11	0.01	4.20E-25	0.10	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 11	Inverse variance weighted (multiplicative random effects)	111	0.11	0.01	2.54E-15	0.10	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 11	Weighted mode	111	0.17	0.05	1.65E-03	0.10	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 11	Weighted median	111	0.12	0.02	1.43E-12	0.10	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 11	DIVW	111	0.11	0.01	0.00E+00	0.10	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 11	GRAPPLE	111	0.12	0.01	1.46E-15	0.10	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 11	mr_raps	111	0.12	0.01	0.00E+00	0.10	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 12	MR Egger	111	0.24	0.05	6.58E-06	0.01	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 12	Inverse variance weighted (fixed effects)	111	0.11	0.01	3.40E-24	0.01	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 12	Inverse variance weighted (multiplicative random effects)	111	0.11	0.01	4.16E-15	0.01	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 12	Weighted mode	111	0.07	0.06	2.89E-01	0.01	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 12	Weighted median	111	0.10	0.02	1.03E-08	0.01	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 12	DIVW	111	0.11	0.01	0.00E+00	0.01	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 12	GRAPPLE	111	0.11	0.01	1.30E-14	0.01	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 12	mr_raps	111	0.11	0.01	0.00E+00	0.01	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 13	MR Egger	111	0.17	0.05	1.92E-03	0.09	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 13	Inverse variance weighted (fixed effects)	111	0.08	0.01	1.37E-12	0.09	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 13	Inverse variance weighted (multiplicative random effects)	111	0.08	0.01	2.89E-08	0.09	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 13	Weighted mode	111	0.07	0.04	9.57E-02	0.09	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 13	Weighted median	111	0.07	0.02	6.80E-05	0.09	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 13	DIVW	111	0.08	0.01	8.93E-13	0.09	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 13	GRAPPLE	111	0.08	0.02	2.34E-07	0.09	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 13	mr_raps	111	0.08	0.01	1.47E-11	0.09	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 14	MR Egger	111	0.19	0.05	5.75E-04	0.04	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 14	Inverse variance weighted (fixed effects)	111	0.08	0.01	1.98E-13	0.04	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 14	Inverse variance weighted (multiplicative random effects)	111	0.08	0.01	2.55E-08	0.04	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 14	Weighted mode	111	0.09	0.04	3.15E-02	0.04	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 14	Weighted median	111	0.08	0.02	8.13E-06	0.04	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 14	DIVW	111	0.08	0.01	1.35E-13	0.04	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 14	GRAPPLE	111	0.09	0.01	9.76E-09	0.04	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 14	mr_raps	111	0.08	0.01	2.99E-13	0.04	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 15	MR Egger	111	0.16	0.05	2.99E-03	0.18	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 15	Inverse variance weighted (fixed effects)	111	0.09	0.01	2.81E-15	0.18	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 15	Inverse variance weighted (multiplicative random effects)	111	0.09	0.01	5.02E-10	0.18	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 15	Weighted mode	111	0.10	0.04	8.59E-03	0.18	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 15	Weighted median	111	0.09	0.02	5.14E-08	0.18	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 15	DIVW	111	0.09	0.01	2.11E-15	0.18	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 15	GRAPPLE	111	0.10	0.02	2.42E-10	0.18	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 15	mr_raps	111	0.10	0.01	0.00E+00	0.18	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 16	MR Egger	111	0.23	0.05	1.92E-05	0.00	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 16	Inverse variance weighted (fixed effects)	111	0.07	0.01	3.85E-09	0.00	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 16	Inverse variance weighted (multiplicative random effects)	111	0.07	0.02	6.58E-06	0.00	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 16	Weighted mode	111	0.09	0.05	4.66E-02	0.00	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 16	Weighted median	111	0.07	0.02	2.77E-05	0.00	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 16	DIVW	111	0.07	0.01	2.19E-09	0.00	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 16	GRAPPLE	111	0.07	0.02	4.76E-06	0.00	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 16	mr_raps	111	0.07	0.01	1.43E-08	0.00	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 2	MR Egger	111	0.11	0.07	1.03E-01	0.76	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 2	Inverse variance weighted (fixed effects)	111	0.09	0.01	8.69E-11	0.76	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 2	Inverse variance weighted (multiplicative random effects)	111	0.09	0.02	9.14E-07	0.76	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 2	Weighted mode	111	0.05	0.06	3.81E-01	0.76	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 2	Weighted median	111	0.07	0.02	3.89E-03	0.76	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 2	DIVW	111	0.09	0.01	5.23E-11	0.76	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 2	GRAPPLE	111	0.09	0.02	3.43E-06	0.76	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 2	mr_raps	111	0.09	0.01	1.44E-09	0.76	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 3	MR Egger	111	0.23	0.06	3.65E-04	0.06	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 3	Inverse variance weighted (fixed effects)	111	0.11	0.01	1.99E-16	0.06	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 3	Inverse variance weighted (multiplicative random effects)	111	0.11	0.02	5.34E-11	0.06	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 3	Weighted mode	111	0.04	0.06	5.08E-01	0.06	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 3	Weighted median	111	0.10	0.02	4.63E-06	0.06	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 3	DIVW	111	0.12	0.01	1.11E-16	0.06	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 3	GRAPPLE	111	0.12	0.02	3.04E-11	0.06	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 3	mr_raps	111	0.12	0.01	2.22E-16	0.06	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 4	MR Egger	111	0.18	0.06	3.13E-03	0.31	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 4	Inverse variance weighted (fixed effects)	111	0.12	0.01	8.29E-24	0.31	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 4	Inverse variance weighted (multiplicative random effects)	111	0.12	0.02	1.34E-13	0.31	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 4	Weighted mode	111	0.14	0.05	9.46E-03	0.31	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 4	Weighted median	111	0.11	0.02	5.41E-09	0.31	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 4	DIVW	111	0.13	0.01	0.00E+00	0.31	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 4	GRAPPLE	111	0.13	0.02	3.06E-13	0.31	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 4	mr_raps	111	0.12	0.01	0.00E+00	0.31	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 5	MR Egger	111	0.18	0.06	3.79E-03	0.35	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 5	Inverse variance weighted (fixed effects)	111	0.12	0.01	7.27E-25	0.35	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 5	Inverse variance weighted (multiplicative random effects)	111	0.12	0.02	8.69E-14	0.35	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 5	Weighted mode	111	0.16	0.05	2.46E-03	0.35	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 5	Weighted median	111	0.13	0.02	9.49E-11	0.35	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 5	DIVW	111	0.12	0.01	0.00E+00	0.35	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 5	GRAPPLE	111	0.13	0.02	1.99E-14	0.35	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 5	mr_raps	111	0.13	0.01	0.00E+00	0.35	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 6	MR Egger	111	0.22	0.06	6.16E-04	0.21	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 6	Inverse variance weighted (fixed effects)	111	0.14	0.01	3.87E-32	0.21	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 6	Inverse variance weighted (multiplicative random effects)	111	0.14	0.02	6.85E-17	0.21	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 6	Weighted mode	111	0.20	0.06	8.35E-04	0.21	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 6	Weighted median	111	0.15	0.02	5.12E-15	0.21	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 6	DIVW	111	0.14	0.01	0.00E+00	0.21	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 6	GRAPPLE	111	0.15	0.02	1.89E-17	0.21	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 6	mr_raps	111	0.15	0.01	0.00E+00	0.21	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 7	MR Egger	111	0.25	0.05	2.51E-06	0.02	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 7	Inverse variance weighted (fixed effects)	111	0.14	0.01	4.16E-35	0.02	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 7	Inverse variance weighted (multiplicative random effects)	111	0.14	0.01	1.63E-21	0.02	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 7	Weighted mode	111	0.09	0.06	1.23E-01	0.02	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 7	Weighted median	111	0.12	0.02	2.32E-11	0.02	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 7	DIVW	111	0.14	0.01	0.00E+00	0.02	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 7	GRAPPLE	111	0.14	0.02	4.68E-20	0.02	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 7	mr_raps	111	0.14	0.01	0.00E+00	0.02	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 8	MR Egger	111	0.20	0.06	5.66E-04	0.17	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 8	Inverse variance weighted (fixed effects)	111	0.13	0.01	7.57E-28	0.17	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 8	Inverse variance weighted (multiplicative random effects)	111	0.13	0.02	1.17E-15	0.17	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 8	Weighted mode	111	0.12	0.05	2.40E-02	0.17	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 8	Weighted median	111	0.11	0.02	3.34E-08	0.17	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 8	DIVW	111	0.13	0.01	0.00E+00	0.17	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 8	GRAPPLE	111	0.12	0.02	8.71E-14	0.17	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 8	mr_raps	111	0.12	0.01	0.00E+00	0.17	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 9	MR Egger	111	0.20	0.06	6.67E-04	0.19	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 9	Inverse variance weighted (fixed effects)	111	0.13	0.01	5.52E-32	0.19	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 9	Inverse variance weighted (multiplicative random effects)	111	0.13	0.02	6.44E-16	0.19	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 9	Weighted mode	111	0.09	0.05	6.67E-02	0.19	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 9	Weighted median	111	0.10	0.02	3.57E-08	0.19	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 9	DIVW	111	0.13	0.01	0.00E+00	0.19	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 9	GRAPPLE	111	0.12	0.02	6.10E-14	0.19	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional myocardial-wall thickness at end-diastole 9	mr_raps	111	0.12	0.01	0.00E+00	0.19	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 12	MR Egger	111	0.17	0.06	8.13E-03	0.13	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 12	Inverse variance weighted (fixed effects)	111	0.08	0.01	4.18E-08	0.13	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 12	Inverse variance weighted (multiplicative random effects)	111	0.08	0.02	8.04E-06	0.13	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 12	Weighted mode	111	0.16	0.05	7.92E-04	0.13	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 12	Weighted median	111	0.09	0.02	8.09E-05	0.13	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 12	DIVW	111	0.08	0.01	2.30E-08	0.13	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 12	GRAPPLE	111	0.08	0.02	1.42E-05	0.13	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 12	mr_raps	111	0.08	0.01	1.40E-08	0.13	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 13	MR Egger	111	0.13	0.06	2.50E-02	0.44	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 13	Inverse variance weighted (fixed effects)	111	0.09	0.01	1.09E-09	0.44	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 13	Inverse variance weighted (multiplicative random effects)	111	0.09	0.02	3.05E-08	0.44	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 13	Weighted mode	111	0.09	0.06	1.39E-01	0.44	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 13	Weighted median	111	0.10	0.02	1.91E-05	0.44	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 13	DIVW	111	0.09	0.01	6.30E-10	0.44	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 13	GRAPPLE	111	0.09	0.02	7.61E-08	0.44	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 13	mr_raps	111	0.09	0.02	1.85E-09	0.44	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 14	MR Egger	111	0.13	0.06	4.16E-02	0.82	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 14	Inverse variance weighted (fixed effects)	111	0.11	0.01	2.50E-14	0.82	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 14	Inverse variance weighted (multiplicative random effects)	111	0.11	0.02	2.31E-11	0.82	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 14	Weighted mode	111	0.11	0.06	5.13E-02	0.82	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 14	Weighted median	111	0.10	0.02	7.41E-06	0.82	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 14	DIVW	111	0.12	0.02	1.78E-14	0.82	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 14	GRAPPLE	111	0.11	0.02	2.30E-09	0.82	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 14	mr_raps	111	0.11	0.02	5.45E-12	0.82	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 15	MR Egger	111	0.08	0.07	2.40E-01	0.92	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 15	Inverse variance weighted (fixed effects)	111	0.08	0.01	9.48E-09	0.92	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 15	Inverse variance weighted (multiplicative random effects)	111	0.08	0.02	3.46E-06	0.92	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 15	Weighted mode	111	0.00	0.06	9.55E-01	0.92	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 15	Weighted median	111	0.06	0.02	3.91E-03	0.92	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 15	DIVW	111	0.09	0.02	5.32E-09	0.92	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 15	GRAPPLE	111	0.08	0.02	1.33E-05	0.92	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 15	mr_raps	111	0.08	0.02	2.62E-07	0.92	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 16	MR Egger	111	0.12	0.07	6.82E-02	0.48	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 16	Inverse variance weighted (fixed effects)	111	0.08	0.01	1.52E-07	0.48	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 16	Inverse variance weighted (multiplicative random effects)	111	0.08	0.02	2.77E-05	0.48	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 16	Weighted mode	111	0.08	0.06	2.08E-01	0.48	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 16	Weighted median	111	0.07	0.02	4.49E-03	0.48	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 16	DIVW	111	0.08	0.01	8.25E-08	0.48	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 16	GRAPPLE	111	0.08	0.02	3.63E-05	0.48	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 16	mr_raps	111	0.08	0.02	1.58E-07	0.48	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 8	MR Egger	111	0.12	0.06	4.84E-02	0.93	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 8	Inverse variance weighted (fixed effects)	111	0.13	0.01	2.59E-17	0.93	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 8	Inverse variance weighted (multiplicative random effects)	111	0.13	0.02	3.64E-14	0.93	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 8	Weighted mode	111	0.17	0.06	7.32E-03	0.93	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 8	Weighted median	111	0.13	0.02	2.25E-08	0.93	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 8	DIVW	111	0.13	0.02	0.00E+00	0.93	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 8	GRAPPLE	111	0.13	0.02	3.34E-13	0.93	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 8	mr_raps	111	0.13	0.02	0.00E+00	0.93	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 9	MR Egger	111	0.11	0.06	5.98E-02	0.83	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 9	Inverse variance weighted (fixed effects)	111	0.10	0.01	2.24E-12	0.83	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 9	Inverse variance weighted (multiplicative random effects)	111	0.10	0.02	6.66E-10	0.83	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 9	Weighted mode	111	0.10	0.05	3.54E-02	0.83	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 9	Weighted median	111	0.10	0.02	3.08E-05	0.83	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 9	DIVW	111	0.10	0.01	1.45E-12	0.83	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 9	GRAPPLE	111	0.11	0.02	1.65E-09	0.83	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Hypertensive diseases (excluding secondary)	Cardiometabolic endpoints	regional radial strain 9	mr_raps	111	0.11	0.02	9.76E-13	0.83	rs10059884,rs10170836,rs10206833,rs10217559,rs1021956,rs10409174,rs10776752,rs10876531,rs10993820,rs1106270,rs11211570,rs1121980,rs113163918,rs113318709,rs11672460,rs117185762,rs11763813,rs11867639,rs11892,rs1214759,rs12258967,rs12509595,rs1275984,rs12942340,rs13112725,rs13121583,rs13126083,rs1317181,rs13306561,rs1383258,rs143465073,rs144413645,rs1446468,rs1515114,rs1555959,rs1590008,rs167479,rs16853076,rs17612845,rs17695879,rs1879053,rs1888693,rs1951631,rs2023843,rs2063123,rs2114754,rs2158375,rs2286526,rs2301250,rs2304616,rs2383206,rs2392929,rs2643826,rs2704368,rs27527,rs2773469,rs34155841,rs35198836,rs35429,rs35783704,rs3796585,rs3820982,rs3918226,rs4233796,rs4371736,rs4409766,rs4638151,rs4649041,rs4685218,rs4685222,rs4721479,rs4804592,rs4932373,rs557011,rs56197924,rs56388234,rs5762879,rs5772,rs59415853,rs604723,rs60595656,rs62434119,rs62436817,rs6560949,rs6714780,rs6771917,rs6841382,rs6860901,rs7101502,rs7123454,rs7125196,rs7196548,rs7246342,rs7246865,rs72779268,rs72831851,rs72877309,rs7302030,rs74661587,rs7552539,rs77309872,rs7809934,rs78302204,rs79780963,rs805262,rs880315,rs9293558,rs9395725,rs9804478,rs9899012,rs9907781
Other heart diseases	Cardiometabolic endpoints	left atrium maximum volume	MR Egger	19	0.26	0.13	6.90E-02	0.60	rs10455872,rs1106270,rs12509595,rs1537373,rs17042121,rs2001255,rs2723321,rs34071855,rs3918226,rs4642230,rs474534,rs56382016,rs624988,rs62531530,rs635634,rs6823438,rs6838973,rs78412528,rs879324
Other heart diseases	Cardiometabolic endpoints	left atrium maximum volume	Inverse variance weighted (fixed effects)	19	0.19	0.04	6.87E-08	0.60	rs10455872,rs1106270,rs12509595,rs1537373,rs17042121,rs2001255,rs2723321,rs34071855,rs3918226,rs4642230,rs474534,rs56382016,rs624988,rs62531530,rs635634,rs6823438,rs6838973,rs78412528,rs879324
Other heart diseases	Cardiometabolic endpoints	left atrium maximum volume	Inverse variance weighted (multiplicative random effects)	19	0.19	0.05	5.22E-05	0.60	rs10455872,rs1106270,rs12509595,rs1537373,rs17042121,rs2001255,rs2723321,rs34071855,rs3918226,rs4642230,rs474534,rs56382016,rs624988,rs62531530,rs635634,rs6823438,rs6838973,rs78412528,rs879324
Other heart diseases	Cardiometabolic endpoints	left atrium maximum volume	Weighted mode	19	0.22	0.12	7.27E-02	0.60	rs10455872,rs1106270,rs12509595,rs1537373,rs17042121,rs2001255,rs2723321,rs34071855,rs3918226,rs4642230,rs474534,rs56382016,rs624988,rs62531530,rs635634,rs6823438,rs6838973,rs78412528,rs879324
Other heart diseases	Cardiometabolic endpoints	left atrium maximum volume	Weighted median	19	0.20	0.06	3.55E-04	0.60	rs10455872,rs1106270,rs12509595,rs1537373,rs17042121,rs2001255,rs2723321,rs34071855,rs3918226,rs4642230,rs474534,rs56382016,rs624988,rs62531530,rs635634,rs6823438,rs6838973,rs78412528,rs879324
Other heart diseases	Cardiometabolic endpoints	left atrium maximum volume	DIVW	19	0.20	0.04	5.80E-08	0.60	rs10455872,rs1106270,rs12509595,rs1537373,rs17042121,rs2001255,rs2723321,rs34071855,rs3918226,rs4642230,rs474534,rs56382016,rs624988,rs62531530,rs635634,rs6823438,rs6838973,rs78412528,rs879324
Other heart diseases	Cardiometabolic endpoints	left atrium maximum volume	GRAPPLE	19	0.19	0.05	1.99E-04	0.60	rs10455872,rs1106270,rs12509595,rs1537373,rs17042121,rs2001255,rs2723321,rs34071855,rs3918226,rs4642230,rs474534,rs56382016,rs624988,rs62531530,rs635634,rs6823438,rs6838973,rs78412528,rs879324
Other heart diseases	Cardiometabolic endpoints	left atrium maximum volume	mr_raps	19	0.20	0.04	2.94E-07	0.60	rs10455872,rs1106270,rs12509595,rs1537373,rs17042121,rs2001255,rs2723321,rs34071855,rs3918226,rs4642230,rs474534,rs56382016,rs624988,rs62531530,rs635634,rs6823438,rs6838973,rs78412528,rs879324
Other heart diseases	Cardiometabolic endpoints	left atrium minimum volume	MR Egger	19	0.32	0.10	7.48E-03	0.30	rs10455872,rs1106270,rs12509595,rs1537373,rs17042121,rs2001255,rs2723321,rs34071855,rs3918226,rs4642230,rs474534,rs56382016,rs624988,rs62531530,rs635634,rs6823438,rs6838973,rs78412528,rs879324
Other heart diseases	Cardiometabolic endpoints	left atrium minimum volume	Inverse variance weighted (fixed effects)	19	0.21	0.04	1.04E-08	0.30	rs10455872,rs1106270,rs12509595,rs1537373,rs17042121,rs2001255,rs2723321,rs34071855,rs3918226,rs4642230,rs474534,rs56382016,rs624988,rs62531530,rs635634,rs6823438,rs6838973,rs78412528,rs879324
Other heart diseases	Cardiometabolic endpoints	left atrium minimum volume	Inverse variance weighted (multiplicative random effects)	19	0.21	0.04	2.24E-08	0.30	rs10455872,rs1106270,rs12509595,rs1537373,rs17042121,rs2001255,rs2723321,rs34071855,rs3918226,rs4642230,rs474534,rs56382016,rs624988,rs62531530,rs635634,rs6823438,rs6838973,rs78412528,rs879324
Other heart diseases	Cardiometabolic endpoints	left atrium minimum volume	Weighted mode	19	0.20	0.12	1.07E-01	0.30	rs10455872,rs1106270,rs12509595,rs1537373,rs17042121,rs2001255,rs2723321,rs34071855,rs3918226,rs4642230,rs474534,rs56382016,rs624988,rs62531530,rs635634,rs6823438,rs6838973,rs78412528,rs879324
Other heart diseases	Cardiometabolic endpoints	left atrium minimum volume	Weighted median	19	0.20	0.06	3.21E-04	0.30	rs10455872,rs1106270,rs12509595,rs1537373,rs17042121,rs2001255,rs2723321,rs34071855,rs3918226,rs4642230,rs474534,rs56382016,rs624988,rs62531530,rs635634,rs6823438,rs6838973,rs78412528,rs879324
Other heart diseases	Cardiometabolic endpoints	left atrium minimum volume	DIVW	19	0.22	0.04	1.00E-08	0.30	rs10455872,rs1106270,rs12509595,rs1537373,rs17042121,rs2001255,rs2723321,rs34071855,rs3918226,rs4642230,rs474534,rs56382016,rs624988,rs62531530,rs635634,rs6823438,rs6838973,rs78412528,rs879324
Other heart diseases	Cardiometabolic endpoints	left atrium minimum volume	GRAPPLE	19	0.21	0.04	1.70E-07	0.30	rs10455872,rs1106270,rs12509595,rs1537373,rs17042121,rs2001255,rs2723321,rs34071855,rs3918226,rs4642230,rs474534,rs56382016,rs624988,rs62531530,rs635634,rs6823438,rs6838973,rs78412528,rs879324
Other heart diseases	Cardiometabolic endpoints	left atrium minimum volume	mr_raps	19	0.21	0.04	1.86E-07	0.30	rs10455872,rs1106270,rs12509595,rs1537373,rs17042121,rs2001255,rs2723321,rs34071855,rs3918226,rs4642230,rs474534,rs56382016,rs624988,rs62531530,rs635634,rs6823438,rs6838973,rs78412528,rs879324
Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	left atrium ejection fraction	MR Egger	78	-0.12	0.03	1.69E-04	0.10	rs10494142,rs11002926,rs112276434,rs112583508,rs113819537,rs114038875,rs115144919,rs11598047,rs117095708,rs118039278,rs12058649,rs12145374,rs12192632,rs12213882,rs12312710,rs12509595,rs12521808,rs1255986,rs12646050,rs12779135,rs12905530,rs12988307,rs13150920,rs13185866,rs1320237,rs1333048,rs1357051,rs139994915,rs147384624,rs147790633,rs149054443,rs1571217,rs167479,rs17042121,rs17608766,rs189220811,rs216198,rs2249105,rs2275354,rs2350545,rs2377991,rs2395579,rs2723321,rs28631169,rs3096493,rs3176323,rs34606058,rs35783704,rs3807989,rs390316,rs4045192,rs4378439,rs4414519,rs4578216,rs4656794,rs4999127,rs529526,rs55985730,rs6026739,rs62337205,rs62475135,rs6488930,rs67329386,rs6813719,rs6838973,rs7174643,rs72675564,rs72700103,rs72700114,rs74564217,rs7522128,rs75557443,rs75658947,rs7650482,rs807282,rs880315,rs883079,rs9922619
Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	left atrium ejection fraction	Inverse variance weighted (fixed effects)	78	-0.07	0.01	4.72E-12	0.10	rs10494142,rs11002926,rs112276434,rs112583508,rs113819537,rs114038875,rs115144919,rs11598047,rs117095708,rs118039278,rs12058649,rs12145374,rs12192632,rs12213882,rs12312710,rs12509595,rs12521808,rs1255986,rs12646050,rs12779135,rs12905530,rs12988307,rs13150920,rs13185866,rs1320237,rs1333048,rs1357051,rs139994915,rs147384624,rs147790633,rs149054443,rs1571217,rs167479,rs17042121,rs17608766,rs189220811,rs216198,rs2249105,rs2275354,rs2350545,rs2377991,rs2395579,rs2723321,rs28631169,rs3096493,rs3176323,rs34606058,rs35783704,rs3807989,rs390316,rs4045192,rs4378439,rs4414519,rs4578216,rs4656794,rs4999127,rs529526,rs55985730,rs6026739,rs62337205,rs62475135,rs6488930,rs67329386,rs6813719,rs6838973,rs7174643,rs72675564,rs72700103,rs72700114,rs74564217,rs7522128,rs75557443,rs75658947,rs7650482,rs807282,rs880315,rs883079,rs9922619
Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	left atrium ejection fraction	Inverse variance weighted (multiplicative random effects)	78	-0.07	0.01	9.78E-09	0.10	rs10494142,rs11002926,rs112276434,rs112583508,rs113819537,rs114038875,rs115144919,rs11598047,rs117095708,rs118039278,rs12058649,rs12145374,rs12192632,rs12213882,rs12312710,rs12509595,rs12521808,rs1255986,rs12646050,rs12779135,rs12905530,rs12988307,rs13150920,rs13185866,rs1320237,rs1333048,rs1357051,rs139994915,rs147384624,rs147790633,rs149054443,rs1571217,rs167479,rs17042121,rs17608766,rs189220811,rs216198,rs2249105,rs2275354,rs2350545,rs2377991,rs2395579,rs2723321,rs28631169,rs3096493,rs3176323,rs34606058,rs35783704,rs3807989,rs390316,rs4045192,rs4378439,rs4414519,rs4578216,rs4656794,rs4999127,rs529526,rs55985730,rs6026739,rs62337205,rs62475135,rs6488930,rs67329386,rs6813719,rs6838973,rs7174643,rs72675564,rs72700103,rs72700114,rs74564217,rs7522128,rs75557443,rs75658947,rs7650482,rs807282,rs880315,rs883079,rs9922619
Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	left atrium ejection fraction	Weighted mode	78	-0.10	0.02	1.07E-04	0.10	rs10494142,rs11002926,rs112276434,rs112583508,rs113819537,rs114038875,rs115144919,rs11598047,rs117095708,rs118039278,rs12058649,rs12145374,rs12192632,rs12213882,rs12312710,rs12509595,rs12521808,rs1255986,rs12646050,rs12779135,rs12905530,rs12988307,rs13150920,rs13185866,rs1320237,rs1333048,rs1357051,rs139994915,rs147384624,rs147790633,rs149054443,rs1571217,rs167479,rs17042121,rs17608766,rs189220811,rs216198,rs2249105,rs2275354,rs2350545,rs2377991,rs2395579,rs2723321,rs28631169,rs3096493,rs3176323,rs34606058,rs35783704,rs3807989,rs390316,rs4045192,rs4378439,rs4414519,rs4578216,rs4656794,rs4999127,rs529526,rs55985730,rs6026739,rs62337205,rs62475135,rs6488930,rs67329386,rs6813719,rs6838973,rs7174643,rs72675564,rs72700103,rs72700114,rs74564217,rs7522128,rs75557443,rs75658947,rs7650482,rs807282,rs880315,rs883079,rs9922619
Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	left atrium ejection fraction	Weighted median	78	-0.09	0.02	1.32E-06	0.10	rs10494142,rs11002926,rs112276434,rs112583508,rs113819537,rs114038875,rs115144919,rs11598047,rs117095708,rs118039278,rs12058649,rs12145374,rs12192632,rs12213882,rs12312710,rs12509595,rs12521808,rs1255986,rs12646050,rs12779135,rs12905530,rs12988307,rs13150920,rs13185866,rs1320237,rs1333048,rs1357051,rs139994915,rs147384624,rs147790633,rs149054443,rs1571217,rs167479,rs17042121,rs17608766,rs189220811,rs216198,rs2249105,rs2275354,rs2350545,rs2377991,rs2395579,rs2723321,rs28631169,rs3096493,rs3176323,rs34606058,rs35783704,rs3807989,rs390316,rs4045192,rs4378439,rs4414519,rs4578216,rs4656794,rs4999127,rs529526,rs55985730,rs6026739,rs62337205,rs62475135,rs6488930,rs67329386,rs6813719,rs6838973,rs7174643,rs72675564,rs72700103,rs72700114,rs74564217,rs7522128,rs75557443,rs75658947,rs7650482,rs807282,rs880315,rs883079,rs9922619
Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	left atrium ejection fraction	DIVW	78	-0.08	0.01	3.06E-12	0.10	rs10494142,rs11002926,rs112276434,rs112583508,rs113819537,rs114038875,rs115144919,rs11598047,rs117095708,rs118039278,rs12058649,rs12145374,rs12192632,rs12213882,rs12312710,rs12509595,rs12521808,rs1255986,rs12646050,rs12779135,rs12905530,rs12988307,rs13150920,rs13185866,rs1320237,rs1333048,rs1357051,rs139994915,rs147384624,rs147790633,rs149054443,rs1571217,rs167479,rs17042121,rs17608766,rs189220811,rs216198,rs2249105,rs2275354,rs2350545,rs2377991,rs2395579,rs2723321,rs28631169,rs3096493,rs3176323,rs34606058,rs35783704,rs3807989,rs390316,rs4045192,rs4378439,rs4414519,rs4578216,rs4656794,rs4999127,rs529526,rs55985730,rs6026739,rs62337205,rs62475135,rs6488930,rs67329386,rs6813719,rs6838973,rs7174643,rs72675564,rs72700103,rs72700114,rs74564217,rs7522128,rs75557443,rs75658947,rs7650482,rs807282,rs880315,rs883079,rs9922619
Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	left atrium ejection fraction	GRAPPLE	78	-0.08	0.01	5.88E-08	0.10	rs10494142,rs11002926,rs112276434,rs112583508,rs113819537,rs114038875,rs115144919,rs11598047,rs117095708,rs118039278,rs12058649,rs12145374,rs12192632,rs12213882,rs12312710,rs12509595,rs12521808,rs1255986,rs12646050,rs12779135,rs12905530,rs12988307,rs13150920,rs13185866,rs1320237,rs1333048,rs1357051,rs139994915,rs147384624,rs147790633,rs149054443,rs1571217,rs167479,rs17042121,rs17608766,rs189220811,rs216198,rs2249105,rs2275354,rs2350545,rs2377991,rs2395579,rs2723321,rs28631169,rs3096493,rs3176323,rs34606058,rs35783704,rs3807989,rs390316,rs4045192,rs4378439,rs4414519,rs4578216,rs4656794,rs4999127,rs529526,rs55985730,rs6026739,rs62337205,rs62475135,rs6488930,rs67329386,rs6813719,rs6838973,rs7174643,rs72675564,rs72700103,rs72700114,rs74564217,rs7522128,rs75557443,rs75658947,rs7650482,rs807282,rs880315,rs883079,rs9922619
Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	left atrium ejection fraction	mr_raps	78	-0.07	0.01	1.52E-10	0.10	rs10494142,rs11002926,rs112276434,rs112583508,rs113819537,rs114038875,rs115144919,rs11598047,rs117095708,rs118039278,rs12058649,rs12145374,rs12192632,rs12213882,rs12312710,rs12509595,rs12521808,rs1255986,rs12646050,rs12779135,rs12905530,rs12988307,rs13150920,rs13185866,rs1320237,rs1333048,rs1357051,rs139994915,rs147384624,rs147790633,rs149054443,rs1571217,rs167479,rs17042121,rs17608766,rs189220811,rs216198,rs2249105,rs2275354,rs2350545,rs2377991,rs2395579,rs2723321,rs28631169,rs3096493,rs3176323,rs34606058,rs35783704,rs3807989,rs390316,rs4045192,rs4378439,rs4414519,rs4578216,rs4656794,rs4999127,rs529526,rs55985730,rs6026739,rs62337205,rs62475135,rs6488930,rs67329386,rs6813719,rs6838973,rs7174643,rs72675564,rs72700103,rs72700114,rs74564217,rs7522128,rs75557443,rs75658947,rs7650482,rs807282,rs880315,rs883079,rs9922619
Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	left atrium maximum volume	MR Egger	78	0.11	0.03	7.26E-05	0.12	rs10494142,rs11002926,rs112276434,rs112583508,rs113819537,rs114038875,rs115144919,rs11598047,rs117095708,rs118039278,rs12058649,rs12145374,rs12192632,rs12213882,rs12312710,rs12509595,rs12521808,rs1255986,rs12646050,rs12779135,rs12905530,rs12988307,rs13150920,rs13185866,rs1320237,rs1333048,rs1357051,rs139994915,rs147384624,rs147790633,rs149054443,rs1571217,rs167479,rs17042121,rs17608766,rs189220811,rs216198,rs2249105,rs2275354,rs2350545,rs2377991,rs2395579,rs2723321,rs28631169,rs3096493,rs3176323,rs34606058,rs35783704,rs3807989,rs390316,rs4045192,rs4378439,rs4414519,rs4578216,rs4656794,rs4999127,rs529526,rs55985730,rs6026739,rs62337205,rs62475135,rs6488930,rs67329386,rs6813719,rs6838973,rs7174643,rs72675564,rs72700103,rs72700114,rs74564217,rs7522128,rs75557443,rs75658947,rs7650482,rs807282,rs880315,rs883079,rs9922619
Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	left atrium maximum volume	Inverse variance weighted (fixed effects)	78	0.07	0.01	2.74E-12	0.12	rs10494142,rs11002926,rs112276434,rs112583508,rs113819537,rs114038875,rs115144919,rs11598047,rs117095708,rs118039278,rs12058649,rs12145374,rs12192632,rs12213882,rs12312710,rs12509595,rs12521808,rs1255986,rs12646050,rs12779135,rs12905530,rs12988307,rs13150920,rs13185866,rs1320237,rs1333048,rs1357051,rs139994915,rs147384624,rs147790633,rs149054443,rs1571217,rs167479,rs17042121,rs17608766,rs189220811,rs216198,rs2249105,rs2275354,rs2350545,rs2377991,rs2395579,rs2723321,rs28631169,rs3096493,rs3176323,rs34606058,rs35783704,rs3807989,rs390316,rs4045192,rs4378439,rs4414519,rs4578216,rs4656794,rs4999127,rs529526,rs55985730,rs6026739,rs62337205,rs62475135,rs6488930,rs67329386,rs6813719,rs6838973,rs7174643,rs72675564,rs72700103,rs72700114,rs74564217,rs7522128,rs75557443,rs75658947,rs7650482,rs807282,rs880315,rs883079,rs9922619
Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	left atrium maximum volume	Inverse variance weighted (multiplicative random effects)	78	0.07	0.01	1.13E-10	0.12	rs10494142,rs11002926,rs112276434,rs112583508,rs113819537,rs114038875,rs115144919,rs11598047,rs117095708,rs118039278,rs12058649,rs12145374,rs12192632,rs12213882,rs12312710,rs12509595,rs12521808,rs1255986,rs12646050,rs12779135,rs12905530,rs12988307,rs13150920,rs13185866,rs1320237,rs1333048,rs1357051,rs139994915,rs147384624,rs147790633,rs149054443,rs1571217,rs167479,rs17042121,rs17608766,rs189220811,rs216198,rs2249105,rs2275354,rs2350545,rs2377991,rs2395579,rs2723321,rs28631169,rs3096493,rs3176323,rs34606058,rs35783704,rs3807989,rs390316,rs4045192,rs4378439,rs4414519,rs4578216,rs4656794,rs4999127,rs529526,rs55985730,rs6026739,rs62337205,rs62475135,rs6488930,rs67329386,rs6813719,rs6838973,rs7174643,rs72675564,rs72700103,rs72700114,rs74564217,rs7522128,rs75557443,rs75658947,rs7650482,rs807282,rs880315,rs883079,rs9922619
Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	left atrium maximum volume	Weighted mode	78	0.12	0.02	1.62E-06	0.12	rs10494142,rs11002926,rs112276434,rs112583508,rs113819537,rs114038875,rs115144919,rs11598047,rs117095708,rs118039278,rs12058649,rs12145374,rs12192632,rs12213882,rs12312710,rs12509595,rs12521808,rs1255986,rs12646050,rs12779135,rs12905530,rs12988307,rs13150920,rs13185866,rs1320237,rs1333048,rs1357051,rs139994915,rs147384624,rs147790633,rs149054443,rs1571217,rs167479,rs17042121,rs17608766,rs189220811,rs216198,rs2249105,rs2275354,rs2350545,rs2377991,rs2395579,rs2723321,rs28631169,rs3096493,rs3176323,rs34606058,rs35783704,rs3807989,rs390316,rs4045192,rs4378439,rs4414519,rs4578216,rs4656794,rs4999127,rs529526,rs55985730,rs6026739,rs62337205,rs62475135,rs6488930,rs67329386,rs6813719,rs6838973,rs7174643,rs72675564,rs72700103,rs72700114,rs74564217,rs7522128,rs75557443,rs75658947,rs7650482,rs807282,rs880315,rs883079,rs9922619
Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	left atrium maximum volume	Weighted median	78	0.09	0.02	1.53E-08	0.12	rs10494142,rs11002926,rs112276434,rs112583508,rs113819537,rs114038875,rs115144919,rs11598047,rs117095708,rs118039278,rs12058649,rs12145374,rs12192632,rs12213882,rs12312710,rs12509595,rs12521808,rs1255986,rs12646050,rs12779135,rs12905530,rs12988307,rs13150920,rs13185866,rs1320237,rs1333048,rs1357051,rs139994915,rs147384624,rs147790633,rs149054443,rs1571217,rs167479,rs17042121,rs17608766,rs189220811,rs216198,rs2249105,rs2275354,rs2350545,rs2377991,rs2395579,rs2723321,rs28631169,rs3096493,rs3176323,rs34606058,rs35783704,rs3807989,rs390316,rs4045192,rs4378439,rs4414519,rs4578216,rs4656794,rs4999127,rs529526,rs55985730,rs6026739,rs62337205,rs62475135,rs6488930,rs67329386,rs6813719,rs6838973,rs7174643,rs72675564,rs72700103,rs72700114,rs74564217,rs7522128,rs75557443,rs75658947,rs7650482,rs807282,rs880315,rs883079,rs9922619
Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	left atrium maximum volume	DIVW	78	0.07	0.01	1.79E-12	0.12	rs10494142,rs11002926,rs112276434,rs112583508,rs113819537,rs114038875,rs115144919,rs11598047,rs117095708,rs118039278,rs12058649,rs12145374,rs12192632,rs12213882,rs12312710,rs12509595,rs12521808,rs1255986,rs12646050,rs12779135,rs12905530,rs12988307,rs13150920,rs13185866,rs1320237,rs1333048,rs1357051,rs139994915,rs147384624,rs147790633,rs149054443,rs1571217,rs167479,rs17042121,rs17608766,rs189220811,rs216198,rs2249105,rs2275354,rs2350545,rs2377991,rs2395579,rs2723321,rs28631169,rs3096493,rs3176323,rs34606058,rs35783704,rs3807989,rs390316,rs4045192,rs4378439,rs4414519,rs4578216,rs4656794,rs4999127,rs529526,rs55985730,rs6026739,rs62337205,rs62475135,rs6488930,rs67329386,rs6813719,rs6838973,rs7174643,rs72675564,rs72700103,rs72700114,rs74564217,rs7522128,rs75557443,rs75658947,rs7650482,rs807282,rs880315,rs883079,rs9922619
Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	left atrium maximum volume	GRAPPLE	78	0.08	0.01	1.87E-11	0.12	rs10494142,rs11002926,rs112276434,rs112583508,rs113819537,rs114038875,rs115144919,rs11598047,rs117095708,rs118039278,rs12058649,rs12145374,rs12192632,rs12213882,rs12312710,rs12509595,rs12521808,rs1255986,rs12646050,rs12779135,rs12905530,rs12988307,rs13150920,rs13185866,rs1320237,rs1333048,rs1357051,rs139994915,rs147384624,rs147790633,rs149054443,rs1571217,rs167479,rs17042121,rs17608766,rs189220811,rs216198,rs2249105,rs2275354,rs2350545,rs2377991,rs2395579,rs2723321,rs28631169,rs3096493,rs3176323,rs34606058,rs35783704,rs3807989,rs390316,rs4045192,rs4378439,rs4414519,rs4578216,rs4656794,rs4999127,rs529526,rs55985730,rs6026739,rs62337205,rs62475135,rs6488930,rs67329386,rs6813719,rs6838973,rs7174643,rs72675564,rs72700103,rs72700114,rs74564217,rs7522128,rs75557443,rs75658947,rs7650482,rs807282,rs880315,rs883079,rs9922619
Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	left atrium maximum volume	mr_raps	78	0.08	0.01	3.75E-13	0.12	rs10494142,rs11002926,rs112276434,rs112583508,rs113819537,rs114038875,rs115144919,rs11598047,rs117095708,rs118039278,rs12058649,rs12145374,rs12192632,rs12213882,rs12312710,rs12509595,rs12521808,rs1255986,rs12646050,rs12779135,rs12905530,rs12988307,rs13150920,rs13185866,rs1320237,rs1333048,rs1357051,rs139994915,rs147384624,rs147790633,rs149054443,rs1571217,rs167479,rs17042121,rs17608766,rs189220811,rs216198,rs2249105,rs2275354,rs2350545,rs2377991,rs2395579,rs2723321,rs28631169,rs3096493,rs3176323,rs34606058,rs35783704,rs3807989,rs390316,rs4045192,rs4378439,rs4414519,rs4578216,rs4656794,rs4999127,rs529526,rs55985730,rs6026739,rs62337205,rs62475135,rs6488930,rs67329386,rs6813719,rs6838973,rs7174643,rs72675564,rs72700103,rs72700114,rs74564217,rs7522128,rs75557443,rs75658947,rs7650482,rs807282,rs880315,rs883079,rs9922619
Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	left atrium minimum volume	MR Egger	78	0.12	0.03	3.58E-05	0.17	rs10494142,rs11002926,rs112276434,rs112583508,rs113819537,rs114038875,rs115144919,rs11598047,rs117095708,rs118039278,rs12058649,rs12145374,rs12192632,rs12213882,rs12312710,rs12509595,rs12521808,rs1255986,rs12646050,rs12779135,rs12905530,rs12988307,rs13150920,rs13185866,rs1320237,rs1333048,rs1357051,rs139994915,rs147384624,rs147790633,rs149054443,rs1571217,rs167479,rs17042121,rs17608766,rs189220811,rs216198,rs2249105,rs2275354,rs2350545,rs2377991,rs2395579,rs2723321,rs28631169,rs3096493,rs3176323,rs34606058,rs35783704,rs3807989,rs390316,rs4045192,rs4378439,rs4414519,rs4578216,rs4656794,rs4999127,rs529526,rs55985730,rs6026739,rs62337205,rs62475135,rs6488930,rs67329386,rs6813719,rs6838973,rs7174643,rs72675564,rs72700103,rs72700114,rs74564217,rs7522128,rs75557443,rs75658947,rs7650482,rs807282,rs880315,rs883079,rs9922619
Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	left atrium minimum volume	Inverse variance weighted (fixed effects)	78	0.08	0.01	3.66E-15	0.17	rs10494142,rs11002926,rs112276434,rs112583508,rs113819537,rs114038875,rs115144919,rs11598047,rs117095708,rs118039278,rs12058649,rs12145374,rs12192632,rs12213882,rs12312710,rs12509595,rs12521808,rs1255986,rs12646050,rs12779135,rs12905530,rs12988307,rs13150920,rs13185866,rs1320237,rs1333048,rs1357051,rs139994915,rs147384624,rs147790633,rs149054443,rs1571217,rs167479,rs17042121,rs17608766,rs189220811,rs216198,rs2249105,rs2275354,rs2350545,rs2377991,rs2395579,rs2723321,rs28631169,rs3096493,rs3176323,rs34606058,rs35783704,rs3807989,rs390316,rs4045192,rs4378439,rs4414519,rs4578216,rs4656794,rs4999127,rs529526,rs55985730,rs6026739,rs62337205,rs62475135,rs6488930,rs67329386,rs6813719,rs6838973,rs7174643,rs72675564,rs72700103,rs72700114,rs74564217,rs7522128,rs75557443,rs75658947,rs7650482,rs807282,rs880315,rs883079,rs9922619
Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	left atrium minimum volume	Inverse variance weighted (multiplicative random effects)	78	0.08	0.01	2.15E-13	0.17	rs10494142,rs11002926,rs112276434,rs112583508,rs113819537,rs114038875,rs115144919,rs11598047,rs117095708,rs118039278,rs12058649,rs12145374,rs12192632,rs12213882,rs12312710,rs12509595,rs12521808,rs1255986,rs12646050,rs12779135,rs12905530,rs12988307,rs13150920,rs13185866,rs1320237,rs1333048,rs1357051,rs139994915,rs147384624,rs147790633,rs149054443,rs1571217,rs167479,rs17042121,rs17608766,rs189220811,rs216198,rs2249105,rs2275354,rs2350545,rs2377991,rs2395579,rs2723321,rs28631169,rs3096493,rs3176323,rs34606058,rs35783704,rs3807989,rs390316,rs4045192,rs4378439,rs4414519,rs4578216,rs4656794,rs4999127,rs529526,rs55985730,rs6026739,rs62337205,rs62475135,rs6488930,rs67329386,rs6813719,rs6838973,rs7174643,rs72675564,rs72700103,rs72700114,rs74564217,rs7522128,rs75557443,rs75658947,rs7650482,rs807282,rs880315,rs883079,rs9922619
Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	left atrium minimum volume	Weighted mode	78	0.12	0.02	8.26E-07	0.17	rs10494142,rs11002926,rs112276434,rs112583508,rs113819537,rs114038875,rs115144919,rs11598047,rs117095708,rs118039278,rs12058649,rs12145374,rs12192632,rs12213882,rs12312710,rs12509595,rs12521808,rs1255986,rs12646050,rs12779135,rs12905530,rs12988307,rs13150920,rs13185866,rs1320237,rs1333048,rs1357051,rs139994915,rs147384624,rs147790633,rs149054443,rs1571217,rs167479,rs17042121,rs17608766,rs189220811,rs216198,rs2249105,rs2275354,rs2350545,rs2377991,rs2395579,rs2723321,rs28631169,rs3096493,rs3176323,rs34606058,rs35783704,rs3807989,rs390316,rs4045192,rs4378439,rs4414519,rs4578216,rs4656794,rs4999127,rs529526,rs55985730,rs6026739,rs62337205,rs62475135,rs6488930,rs67329386,rs6813719,rs6838973,rs7174643,rs72675564,rs72700103,rs72700114,rs74564217,rs7522128,rs75557443,rs75658947,rs7650482,rs807282,rs880315,rs883079,rs9922619
Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	left atrium minimum volume	Weighted median	78	0.10	0.02	2.87E-09	0.17	rs10494142,rs11002926,rs112276434,rs112583508,rs113819537,rs114038875,rs115144919,rs11598047,rs117095708,rs118039278,rs12058649,rs12145374,rs12192632,rs12213882,rs12312710,rs12509595,rs12521808,rs1255986,rs12646050,rs12779135,rs12905530,rs12988307,rs13150920,rs13185866,rs1320237,rs1333048,rs1357051,rs139994915,rs147384624,rs147790633,rs149054443,rs1571217,rs167479,rs17042121,rs17608766,rs189220811,rs216198,rs2249105,rs2275354,rs2350545,rs2377991,rs2395579,rs2723321,rs28631169,rs3096493,rs3176323,rs34606058,rs35783704,rs3807989,rs390316,rs4045192,rs4378439,rs4414519,rs4578216,rs4656794,rs4999127,rs529526,rs55985730,rs6026739,rs62337205,rs62475135,rs6488930,rs67329386,rs6813719,rs6838973,rs7174643,rs72675564,rs72700103,rs72700114,rs74564217,rs7522128,rs75557443,rs75658947,rs7650482,rs807282,rs880315,rs883079,rs9922619
Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	left atrium minimum volume	DIVW	78	0.08	0.01	2.78E-15	0.17	rs10494142,rs11002926,rs112276434,rs112583508,rs113819537,rs114038875,rs115144919,rs11598047,rs117095708,rs118039278,rs12058649,rs12145374,rs12192632,rs12213882,rs12312710,rs12509595,rs12521808,rs1255986,rs12646050,rs12779135,rs12905530,rs12988307,rs13150920,rs13185866,rs1320237,rs1333048,rs1357051,rs139994915,rs147384624,rs147790633,rs149054443,rs1571217,rs167479,rs17042121,rs17608766,rs189220811,rs216198,rs2249105,rs2275354,rs2350545,rs2377991,rs2395579,rs2723321,rs28631169,rs3096493,rs3176323,rs34606058,rs35783704,rs3807989,rs390316,rs4045192,rs4378439,rs4414519,rs4578216,rs4656794,rs4999127,rs529526,rs55985730,rs6026739,rs62337205,rs62475135,rs6488930,rs67329386,rs6813719,rs6838973,rs7174643,rs72675564,rs72700103,rs72700114,rs74564217,rs7522128,rs75557443,rs75658947,rs7650482,rs807282,rs880315,rs883079,rs9922619
Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	left atrium minimum volume	GRAPPLE	78	0.09	0.01	1.56E-13	0.17	rs10494142,rs11002926,rs112276434,rs112583508,rs113819537,rs114038875,rs115144919,rs11598047,rs117095708,rs118039278,rs12058649,rs12145374,rs12192632,rs12213882,rs12312710,rs12509595,rs12521808,rs1255986,rs12646050,rs12779135,rs12905530,rs12988307,rs13150920,rs13185866,rs1320237,rs1333048,rs1357051,rs139994915,rs147384624,rs147790633,rs149054443,rs1571217,rs167479,rs17042121,rs17608766,rs189220811,rs216198,rs2249105,rs2275354,rs2350545,rs2377991,rs2395579,rs2723321,rs28631169,rs3096493,rs3176323,rs34606058,rs35783704,rs3807989,rs390316,rs4045192,rs4378439,rs4414519,rs4578216,rs4656794,rs4999127,rs529526,rs55985730,rs6026739,rs62337205,rs62475135,rs6488930,rs67329386,rs6813719,rs6838973,rs7174643,rs72675564,rs72700103,rs72700114,rs74564217,rs7522128,rs75557443,rs75658947,rs7650482,rs807282,rs880315,rs883079,rs9922619
Atrial fibrillation and flutter	IX Diseases of the circulatory system (I9_)	left atrium minimum volume	mr_raps	78	0.09	0.01	6.22E-15	0.17	rs10494142,rs11002926,rs112276434,rs112583508,rs113819537,rs114038875,rs115144919,rs11598047,rs117095708,rs118039278,rs12058649,rs12145374,rs12192632,rs12213882,rs12312710,rs12509595,rs12521808,rs1255986,rs12646050,rs12779135,rs12905530,rs12988307,rs13150920,rs13185866,rs1320237,rs1333048,rs1357051,rs139994915,rs147384624,rs147790633,rs149054443,rs1571217,rs167479,rs17042121,rs17608766,rs189220811,rs216198,rs2249105,rs2275354,rs2350545,rs2377991,rs2395579,rs2723321,rs28631169,rs3096493,rs3176323,rs34606058,rs35783704,rs3807989,rs390316,rs4045192,rs4378439,rs4414519,rs4578216,rs4656794,rs4999127,rs529526,rs55985730,rs6026739,rs62337205,rs62475135,rs6488930,rs67329386,rs6813719,rs6838973,rs7174643,rs72675564,rs72700103,rs72700114,rs74564217,rs7522128,rs75557443,rs75658947,rs7650482,rs807282,rs880315,rs883079,rs9922619
Angina pectoris	IX Diseases of the circulatory system (I9_)	ascending aorta maximum area	MR Egger	41	-0.03	0.06	5.59E-01	0.43	rs10305838,rs1044506,rs10455872,rs10757272,rs10871312,rs11238794,rs113113862,rs11591147,rs117733303,rs1199337,rs12705390,rs13134800,rs137943060,rs1835346,rs2002854,rs2107595,rs28451064,rs2945845,rs2954017,rs3918226,rs4350997,rs499883,rs59877521,rs6120750,rs629301,rs6569898,rs6705330,rs6771973,rs7036656,rs7047414,rs72895829,rs7412,rs7500448,rs75500872,rs7573066,rs7860576,rs9349379,rs9515203,rs964184,rs9677499,rs9970807
Angina pectoris	IX Diseases of the circulatory system (I9_)	ascending aorta maximum area	Inverse variance weighted (fixed effects)	41	-0.08	0.01	1.44E-07	0.43	rs10305838,rs1044506,rs10455872,rs10757272,rs10871312,rs11238794,rs113113862,rs11591147,rs117733303,rs1199337,rs12705390,rs13134800,rs137943060,rs1835346,rs2002854,rs2107595,rs28451064,rs2945845,rs2954017,rs3918226,rs4350997,rs499883,rs59877521,rs6120750,rs629301,rs6569898,rs6705330,rs6771973,rs7036656,rs7047414,rs72895829,rs7412,rs7500448,rs75500872,rs7573066,rs7860576,rs9349379,rs9515203,rs964184,rs9677499,rs9970807
Angina pectoris	IX Diseases of the circulatory system (I9_)	ascending aorta maximum area	Inverse variance weighted (multiplicative random effects)	41	-0.08	0.02	2.38E-03	0.43	rs10305838,rs1044506,rs10455872,rs10757272,rs10871312,rs11238794,rs113113862,rs11591147,rs117733303,rs1199337,rs12705390,rs13134800,rs137943060,rs1835346,rs2002854,rs2107595,rs28451064,rs2945845,rs2954017,rs3918226,rs4350997,rs499883,rs59877521,rs6120750,rs629301,rs6569898,rs6705330,rs6771973,rs7036656,rs7047414,rs72895829,rs7412,rs7500448,rs75500872,rs7573066,rs7860576,rs9349379,rs9515203,rs964184,rs9677499,rs9970807
Angina pectoris	IX Diseases of the circulatory system (I9_)	ascending aorta maximum area	Weighted mode	41	0.00	0.06	9.45E-01	0.43	rs10305838,rs1044506,rs10455872,rs10757272,rs10871312,rs11238794,rs113113862,rs11591147,rs117733303,rs1199337,rs12705390,rs13134800,rs137943060,rs1835346,rs2002854,rs2107595,rs28451064,rs2945845,rs2954017,rs3918226,rs4350997,rs499883,rs59877521,rs6120750,rs629301,rs6569898,rs6705330,rs6771973,rs7036656,rs7047414,rs72895829,rs7412,rs7500448,rs75500872,rs7573066,rs7860576,rs9349379,rs9515203,rs964184,rs9677499,rs9970807
Angina pectoris	IX Diseases of the circulatory system (I9_)	ascending aorta maximum area	Weighted median	41	-0.06	0.03	1.55E-02	0.43	rs10305838,rs1044506,rs10455872,rs10757272,rs10871312,rs11238794,rs113113862,rs11591147,rs117733303,rs1199337,rs12705390,rs13134800,rs137943060,rs1835346,rs2002854,rs2107595,rs28451064,rs2945845,rs2954017,rs3918226,rs4350997,rs499883,rs59877521,rs6120750,rs629301,rs6569898,rs6705330,rs6771973,rs7036656,rs7047414,rs72895829,rs7412,rs7500448,rs75500872,rs7573066,rs7860576,rs9349379,rs9515203,rs964184,rs9677499,rs9970807
Angina pectoris	IX Diseases of the circulatory system (I9_)	ascending aorta maximum area	DIVW	41	-0.08	0.01	8.70E-08	0.43	rs10305838,rs1044506,rs10455872,rs10757272,rs10871312,rs11238794,rs113113862,rs11591147,rs117733303,rs1199337,rs12705390,rs13134800,rs137943060,rs1835346,rs2002854,rs2107595,rs28451064,rs2945845,rs2954017,rs3918226,rs4350997,rs499883,rs59877521,rs6120750,rs629301,rs6569898,rs6705330,rs6771973,rs7036656,rs7047414,rs72895829,rs7412,rs7500448,rs75500872,rs7573066,rs7860576,rs9349379,rs9515203,rs964184,rs9677499,rs9970807
Angina pectoris	IX Diseases of the circulatory system (I9_)	ascending aorta maximum area	GRAPPLE	41	-0.05	0.02	4.13E-02	0.43	rs10305838,rs1044506,rs10455872,rs10757272,rs10871312,rs11238794,rs113113862,rs11591147,rs117733303,rs1199337,rs12705390,rs13134800,rs137943060,rs1835346,rs2002854,rs2107595,rs28451064,rs2945845,rs2954017,rs3918226,rs4350997,rs499883,rs59877521,rs6120750,rs629301,rs6569898,rs6705330,rs6771973,rs7036656,rs7047414,rs72895829,rs7412,rs7500448,rs75500872,rs7573066,rs7860576,rs9349379,rs9515203,rs964184,rs9677499,rs9970807
Angina pectoris	IX Diseases of the circulatory system (I9_)	ascending aorta maximum area	mr_raps	41	-0.06	0.01	6.19E-05	0.43	rs10305838,rs1044506,rs10455872,rs10757272,rs10871312,rs11238794,rs113113862,rs11591147,rs117733303,rs1199337,rs12705390,rs13134800,rs137943060,rs1835346,rs2002854,rs2107595,rs28451064,rs2945845,rs2954017,rs3918226,rs4350997,rs499883,rs59877521,rs6120750,rs629301,rs6569898,rs6705330,rs6771973,rs7036656,rs7047414,rs72895829,rs7412,rs7500448,rs75500872,rs7573066,rs7860576,rs9349379,rs9515203,rs964184,rs9677499,rs9970807
Angina pectoris	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	MR Egger	41	-0.03	0.06	5.57E-01	0.34	rs10305838,rs1044506,rs10455872,rs10757272,rs10871312,rs11238794,rs113113862,rs11591147,rs117733303,rs1199337,rs12705390,rs13134800,rs137943060,rs1835346,rs2002854,rs2107595,rs28451064,rs2945845,rs2954017,rs3918226,rs4350997,rs499883,rs59877521,rs6120750,rs629301,rs6569898,rs6705330,rs6771973,rs7036656,rs7047414,rs72895829,rs7412,rs7500448,rs75500872,rs7573066,rs7860576,rs9349379,rs9515203,rs964184,rs9677499,rs9970807
Angina pectoris	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	Inverse variance weighted (fixed effects)	41	-0.08	0.01	8.65E-09	0.34	rs10305838,rs1044506,rs10455872,rs10757272,rs10871312,rs11238794,rs113113862,rs11591147,rs117733303,rs1199337,rs12705390,rs13134800,rs137943060,rs1835346,rs2002854,rs2107595,rs28451064,rs2945845,rs2954017,rs3918226,rs4350997,rs499883,rs59877521,rs6120750,rs629301,rs6569898,rs6705330,rs6771973,rs7036656,rs7047414,rs72895829,rs7412,rs7500448,rs75500872,rs7573066,rs7860576,rs9349379,rs9515203,rs964184,rs9677499,rs9970807
Angina pectoris	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	Inverse variance weighted (multiplicative random effects)	41	-0.08	0.02	7.62E-04	0.34	rs10305838,rs1044506,rs10455872,rs10757272,rs10871312,rs11238794,rs113113862,rs11591147,rs117733303,rs1199337,rs12705390,rs13134800,rs137943060,rs1835346,rs2002854,rs2107595,rs28451064,rs2945845,rs2954017,rs3918226,rs4350997,rs499883,rs59877521,rs6120750,rs629301,rs6569898,rs6705330,rs6771973,rs7036656,rs7047414,rs72895829,rs7412,rs7500448,rs75500872,rs7573066,rs7860576,rs9349379,rs9515203,rs964184,rs9677499,rs9970807
Angina pectoris	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	Weighted mode	41	0.01	0.04	8.77E-01	0.34	rs10305838,rs1044506,rs10455872,rs10757272,rs10871312,rs11238794,rs113113862,rs11591147,rs117733303,rs1199337,rs12705390,rs13134800,rs137943060,rs1835346,rs2002854,rs2107595,rs28451064,rs2945845,rs2954017,rs3918226,rs4350997,rs499883,rs59877521,rs6120750,rs629301,rs6569898,rs6705330,rs6771973,rs7036656,rs7047414,rs72895829,rs7412,rs7500448,rs75500872,rs7573066,rs7860576,rs9349379,rs9515203,rs964184,rs9677499,rs9970807
Angina pectoris	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	Weighted median	41	-0.05	0.03	2.96E-02	0.34	rs10305838,rs1044506,rs10455872,rs10757272,rs10871312,rs11238794,rs113113862,rs11591147,rs117733303,rs1199337,rs12705390,rs13134800,rs137943060,rs1835346,rs2002854,rs2107595,rs28451064,rs2945845,rs2954017,rs3918226,rs4350997,rs499883,rs59877521,rs6120750,rs629301,rs6569898,rs6705330,rs6771973,rs7036656,rs7047414,rs72895829,rs7412,rs7500448,rs75500872,rs7573066,rs7860576,rs9349379,rs9515203,rs964184,rs9677499,rs9970807
Angina pectoris	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	DIVW	41	-0.08	0.01	5.65E-09	0.34	rs10305838,rs1044506,rs10455872,rs10757272,rs10871312,rs11238794,rs113113862,rs11591147,rs117733303,rs1199337,rs12705390,rs13134800,rs137943060,rs1835346,rs2002854,rs2107595,rs28451064,rs2945845,rs2954017,rs3918226,rs4350997,rs499883,rs59877521,rs6120750,rs629301,rs6569898,rs6705330,rs6771973,rs7036656,rs7047414,rs72895829,rs7412,rs7500448,rs75500872,rs7573066,rs7860576,rs9349379,rs9515203,rs964184,rs9677499,rs9970807
Angina pectoris	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	GRAPPLE	41	-0.06	0.02	2.28E-02	0.34	rs10305838,rs1044506,rs10455872,rs10757272,rs10871312,rs11238794,rs113113862,rs11591147,rs117733303,rs1199337,rs12705390,rs13134800,rs137943060,rs1835346,rs2002854,rs2107595,rs28451064,rs2945845,rs2954017,rs3918226,rs4350997,rs499883,rs59877521,rs6120750,rs629301,rs6569898,rs6705330,rs6771973,rs7036656,rs7047414,rs72895829,rs7412,rs7500448,rs75500872,rs7573066,rs7860576,rs9349379,rs9515203,rs964184,rs9677499,rs9970807
Angina pectoris	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	mr_raps	41	-0.07	0.01	8.92E-06	0.34	rs10305838,rs1044506,rs10455872,rs10757272,rs10871312,rs11238794,rs113113862,rs11591147,rs117733303,rs1199337,rs12705390,rs13134800,rs137943060,rs1835346,rs2002854,rs2107595,rs28451064,rs2945845,rs2954017,rs3918226,rs4350997,rs499883,rs59877521,rs6120750,rs629301,rs6569898,rs6705330,rs6771973,rs7036656,rs7047414,rs72895829,rs7412,rs7500448,rs75500872,rs7573066,rs7860576,rs9349379,rs9515203,rs964184,rs9677499,rs9970807
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	ascending aorta maximum area	MR Egger	7	0.14	0.29	6.53E-01	0.62	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	ascending aorta maximum area	Inverse variance weighted (fixed effects)	7	0.29	0.02	2.17E-36	0.62	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	ascending aorta maximum area	Inverse variance weighted (multiplicative random effects)	7	0.29	0.08	5.51E-04	0.62	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	ascending aorta maximum area	Weighted mode	7	0.10	0.05	8.02E-02	0.62	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	ascending aorta maximum area	Weighted median	7	0.10	0.05	5.30E-02	0.62	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	ascending aorta maximum area	DIVW	7	0.29	0.03	0.00E+00	0.62	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	ascending aorta maximum area	GRAPPLE	7	0.20	0.08	9.81E-03	0.62	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	ascending aorta maximum area	mr_raps	7	0.33	0.03	0.00E+00	0.62	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	MR Egger	7	0.17	0.27	5.70E-01	0.65	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	Inverse variance weighted (fixed effects)	7	0.29	0.02	2.30E-38	0.65	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	Inverse variance weighted (multiplicative random effects)	7	0.29	0.08	1.45E-04	0.65	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	Weighted mode	7	0.12	0.04	2.76E-02	0.65	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	Weighted median	7	0.16	0.05	8.49E-04	0.65	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	DIVW	7	0.30	0.03	0.00E+00	0.65	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	GRAPPLE	7	0.22	0.08	4.14E-03	0.65	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	mr_raps	7	0.32	0.03	0.00E+00	0.65	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	MR Egger	7	0.08	0.07	2.87E-01	0.25	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	Inverse variance weighted (fixed effects)	7	0.17	0.02	1.58E-17	0.25	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	Inverse variance weighted (multiplicative random effects)	7	0.17	0.02	1.78E-14	0.25	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	Weighted mode	7	0.13	0.04	2.11E-02	0.25	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	Weighted median	7	0.15	0.03	2.22E-06	0.25	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	DIVW	7	0.17	0.02	3.77E-14	0.25	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	GRAPPLE	7	0.17	0.02	2.54E-12	0.25	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	mr_raps	7	0.17	0.02	3.74E-13	0.25	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	MR Egger	7	0.13	0.06	1.03E-01	0.45	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	Inverse variance weighted (fixed effects)	7	0.18	0.02	4.78E-20	0.45	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	Inverse variance weighted (multiplicative random effects)	7	0.18	0.02	3.41E-31	0.45	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	Weighted mode	7	0.17	0.04	4.12E-03	0.45	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	Weighted median	7	0.18	0.03	2.81E-10	0.45	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	DIVW	7	0.18	0.02	1.33E-15	0.45	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	GRAPPLE	7	0.18	0.02	1.24E-14	0.45	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Aortic aneurysm	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	mr_raps	7	0.18	0.02	2.22E-14	0.45	rs11172113,rs112009052,rs11222084,rs11618858,rs12030801,rs36029774,rs77097530
Major coronary heart disease event	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	MR Egger	53	-0.01	0.06	8.97E-01	0.28	rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs113113862,rs11591147,rs11617955,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17110517,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28451064,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs494198,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs6946226,rs7036656,rs7158073,rs72749233,rs7412,rs7500448,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184
Major coronary heart disease event	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	Inverse variance weighted (fixed effects)	53	-0.07	0.01	1.26E-08	0.28	rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs113113862,rs11591147,rs11617955,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17110517,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28451064,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs494198,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs6946226,rs7036656,rs7158073,rs72749233,rs7412,rs7500448,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184
Major coronary heart disease event	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	Inverse variance weighted (multiplicative random effects)	53	-0.07	0.03	6.41E-03	0.28	rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs113113862,rs11591147,rs11617955,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17110517,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28451064,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs494198,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs6946226,rs7036656,rs7158073,rs72749233,rs7412,rs7500448,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184
Major coronary heart disease event	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	Weighted mode	53	-0.03	0.03	2.46E-01	0.28	rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs113113862,rs11591147,rs11617955,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17110517,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28451064,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs494198,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs6946226,rs7036656,rs7158073,rs72749233,rs7412,rs7500448,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184
Major coronary heart disease event	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	Weighted median	53	-0.03	0.02	1.08E-01	0.28	rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs113113862,rs11591147,rs11617955,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17110517,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28451064,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs494198,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs6946226,rs7036656,rs7158073,rs72749233,rs7412,rs7500448,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184
Major coronary heart disease event	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	DIVW	53	-0.07	0.01	7.82E-09	0.28	rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs113113862,rs11591147,rs11617955,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17110517,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28451064,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs494198,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs6946226,rs7036656,rs7158073,rs72749233,rs7412,rs7500448,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184
Major coronary heart disease event	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	GRAPPLE	53	-0.04	0.02	7.10E-02	0.28	rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs113113862,rs11591147,rs11617955,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17110517,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28451064,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs494198,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs6946226,rs7036656,rs7158073,rs72749233,rs7412,rs7500448,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184
Major coronary heart disease event	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	mr_raps	53	-0.05	0.01	7.83E-05	0.28	rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs113113862,rs11591147,rs11617955,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17110517,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28451064,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs494198,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs6946226,rs7036656,rs7158073,rs72749233,rs7412,rs7500448,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184
Major coronary heart disease event	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	MR Egger	53	-0.02	0.06	7.86E-01	0.31	rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs113113862,rs11591147,rs11617955,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17110517,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28451064,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs494198,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs6946226,rs7036656,rs7158073,rs72749233,rs7412,rs7500448,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184
Major coronary heart disease event	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	Inverse variance weighted (fixed effects)	53	-0.08	0.01	8.77E-10	0.31	rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs113113862,rs11591147,rs11617955,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17110517,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28451064,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs494198,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs6946226,rs7036656,rs7158073,rs72749233,rs7412,rs7500448,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184
Major coronary heart disease event	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	Inverse variance weighted (multiplicative random effects)	53	-0.08	0.03	3.67E-03	0.31	rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs113113862,rs11591147,rs11617955,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17110517,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28451064,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs494198,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs6946226,rs7036656,rs7158073,rs72749233,rs7412,rs7500448,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184
Major coronary heart disease event	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	Weighted mode	53	-0.03	0.03	3.02E-01	0.31	rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs113113862,rs11591147,rs11617955,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17110517,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28451064,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs494198,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs6946226,rs7036656,rs7158073,rs72749233,rs7412,rs7500448,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184
Major coronary heart disease event	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	Weighted median	53	-0.03	0.02	9.96E-02	0.31	rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs113113862,rs11591147,rs11617955,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17110517,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28451064,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs494198,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs6946226,rs7036656,rs7158073,rs72749233,rs7412,rs7500448,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184
Major coronary heart disease event	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	DIVW	53	-0.08	0.01	5.83E-10	0.31	rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs113113862,rs11591147,rs11617955,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17110517,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28451064,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs494198,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs6946226,rs7036656,rs7158073,rs72749233,rs7412,rs7500448,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184
Major coronary heart disease event	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	GRAPPLE	53	-0.04	0.02	3.87E-02	0.31	rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs113113862,rs11591147,rs11617955,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17110517,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28451064,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs494198,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs6946226,rs7036656,rs7158073,rs72749233,rs7412,rs7500448,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184
Major coronary heart disease event	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	mr_raps	53	-0.05	0.01	1.19E-05	0.31	rs10402946,rs10431974,rs1044506,rs10455872,rs10811665,rs10945646,rs10965106,rs11238794,rs113113862,rs11591147,rs11617955,rs117733303,rs1199338,rs1208256,rs12438645,rs12474528,rs12941836,rs13134800,rs137943060,rs17110517,rs17114046,rs17163301,rs17411045,rs1835346,rs2044474,rs2107595,rs28451064,rs28605759,rs2954017,rs35166119,rs3918226,rs4350997,rs494198,rs5344,rs6119534,rs62341322,rs629301,rs653178,rs67370089,rs6892439,rs6946226,rs7036656,rs7158073,rs72749233,rs7412,rs7500448,rs7608755,rs7668383,rs77028772,rs78100181,rs9349379,rs9515203,rs964184
Coronary atherosclerosis	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	MR Egger	60	-0.05	0.05	3.43E-01	0.78	rs10431974,rs1044506,rs10455872,rs10774624,rs10811665,rs10945646,rs11170821,rs113113862,rs1133220,rs11591147,rs11619038,rs11635498,rs11698996,rs117733303,rs1199337,rs12447309,rs12705390,rs12901658,rs13134800,rs137943060,rs1384705,rs1423457,rs1429125,rs1537371,rs1568488,rs16942194,rs1763943,rs1822200,rs1835346,rs2000660,rs2002854,rs2027939,rs2107595,rs2246828,rs28451064,rs28601761,rs3741298,rs3829964,rs3918226,rs4835377,rs5344,rs553741,rs59877521,rs629301,rs6741243,rs6921231,rs7158073,rs7209564,rs72661887,rs72664324,rs72794188,rs7412,rs7478408,rs7608755,rs7659823,rs7774311,rs7860576,rs7995370,rs9349379,rs9515203
Coronary atherosclerosis	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	Inverse variance weighted (fixed effects)	60	-0.06	0.01	2.26E-06	0.78	rs10431974,rs1044506,rs10455872,rs10774624,rs10811665,rs10945646,rs11170821,rs113113862,rs1133220,rs11591147,rs11619038,rs11635498,rs11698996,rs117733303,rs1199337,rs12447309,rs12705390,rs12901658,rs13134800,rs137943060,rs1384705,rs1423457,rs1429125,rs1537371,rs1568488,rs16942194,rs1763943,rs1822200,rs1835346,rs2000660,rs2002854,rs2027939,rs2107595,rs2246828,rs28451064,rs28601761,rs3741298,rs3829964,rs3918226,rs4835377,rs5344,rs553741,rs59877521,rs629301,rs6741243,rs6921231,rs7158073,rs7209564,rs72661887,rs72664324,rs72794188,rs7412,rs7478408,rs7608755,rs7659823,rs7774311,rs7860576,rs7995370,rs9349379,rs9515203
Coronary atherosclerosis	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	Inverse variance weighted (multiplicative random effects)	60	-0.06	0.02	6.67E-03	0.78	rs10431974,rs1044506,rs10455872,rs10774624,rs10811665,rs10945646,rs11170821,rs113113862,rs1133220,rs11591147,rs11619038,rs11635498,rs11698996,rs117733303,rs1199337,rs12447309,rs12705390,rs12901658,rs13134800,rs137943060,rs1384705,rs1423457,rs1429125,rs1537371,rs1568488,rs16942194,rs1763943,rs1822200,rs1835346,rs2000660,rs2002854,rs2027939,rs2107595,rs2246828,rs28451064,rs28601761,rs3741298,rs3829964,rs3918226,rs4835377,rs5344,rs553741,rs59877521,rs629301,rs6741243,rs6921231,rs7158073,rs7209564,rs72661887,rs72664324,rs72794188,rs7412,rs7478408,rs7608755,rs7659823,rs7774311,rs7860576,rs7995370,rs9349379,rs9515203
Coronary atherosclerosis	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	Weighted mode	60	0.00	0.04	9.77E-01	0.78	rs10431974,rs1044506,rs10455872,rs10774624,rs10811665,rs10945646,rs11170821,rs113113862,rs1133220,rs11591147,rs11619038,rs11635498,rs11698996,rs117733303,rs1199337,rs12447309,rs12705390,rs12901658,rs13134800,rs137943060,rs1384705,rs1423457,rs1429125,rs1537371,rs1568488,rs16942194,rs1763943,rs1822200,rs1835346,rs2000660,rs2002854,rs2027939,rs2107595,rs2246828,rs28451064,rs28601761,rs3741298,rs3829964,rs3918226,rs4835377,rs5344,rs553741,rs59877521,rs629301,rs6741243,rs6921231,rs7158073,rs7209564,rs72661887,rs72664324,rs72794188,rs7412,rs7478408,rs7608755,rs7659823,rs7774311,rs7860576,rs7995370,rs9349379,rs9515203
Coronary atherosclerosis	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	Weighted median	60	-0.04	0.02	8.96E-02	0.78	rs10431974,rs1044506,rs10455872,rs10774624,rs10811665,rs10945646,rs11170821,rs113113862,rs1133220,rs11591147,rs11619038,rs11635498,rs11698996,rs117733303,rs1199337,rs12447309,rs12705390,rs12901658,rs13134800,rs137943060,rs1384705,rs1423457,rs1429125,rs1537371,rs1568488,rs16942194,rs1763943,rs1822200,rs1835346,rs2000660,rs2002854,rs2027939,rs2107595,rs2246828,rs28451064,rs28601761,rs3741298,rs3829964,rs3918226,rs4835377,rs5344,rs553741,rs59877521,rs629301,rs6741243,rs6921231,rs7158073,rs7209564,rs72661887,rs72664324,rs72794188,rs7412,rs7478408,rs7608755,rs7659823,rs7774311,rs7860576,rs7995370,rs9349379,rs9515203
Coronary atherosclerosis	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	DIVW	60	-0.06	0.01	1.22E-06	0.78	rs10431974,rs1044506,rs10455872,rs10774624,rs10811665,rs10945646,rs11170821,rs113113862,rs1133220,rs11591147,rs11619038,rs11635498,rs11698996,rs117733303,rs1199337,rs12447309,rs12705390,rs12901658,rs13134800,rs137943060,rs1384705,rs1423457,rs1429125,rs1537371,rs1568488,rs16942194,rs1763943,rs1822200,rs1835346,rs2000660,rs2002854,rs2027939,rs2107595,rs2246828,rs28451064,rs28601761,rs3741298,rs3829964,rs3918226,rs4835377,rs5344,rs553741,rs59877521,rs629301,rs6741243,rs6921231,rs7158073,rs7209564,rs72661887,rs72664324,rs72794188,rs7412,rs7478408,rs7608755,rs7659823,rs7774311,rs7860576,rs7995370,rs9349379,rs9515203
Coronary atherosclerosis	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	GRAPPLE	60	-0.05	0.02	2.89E-02	0.78	rs10431974,rs1044506,rs10455872,rs10774624,rs10811665,rs10945646,rs11170821,rs113113862,rs1133220,rs11591147,rs11619038,rs11635498,rs11698996,rs117733303,rs1199337,rs12447309,rs12705390,rs12901658,rs13134800,rs137943060,rs1384705,rs1423457,rs1429125,rs1537371,rs1568488,rs16942194,rs1763943,rs1822200,rs1835346,rs2000660,rs2002854,rs2027939,rs2107595,rs2246828,rs28451064,rs28601761,rs3741298,rs3829964,rs3918226,rs4835377,rs5344,rs553741,rs59877521,rs629301,rs6741243,rs6921231,rs7158073,rs7209564,rs72661887,rs72664324,rs72794188,rs7412,rs7478408,rs7608755,rs7659823,rs7774311,rs7860576,rs7995370,rs9349379,rs9515203
Coronary atherosclerosis	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	mr_raps	60	-0.05	0.01	3.10E-05	0.78	rs10431974,rs1044506,rs10455872,rs10774624,rs10811665,rs10945646,rs11170821,rs113113862,rs1133220,rs11591147,rs11619038,rs11635498,rs11698996,rs117733303,rs1199337,rs12447309,rs12705390,rs12901658,rs13134800,rs137943060,rs1384705,rs1423457,rs1429125,rs1537371,rs1568488,rs16942194,rs1763943,rs1822200,rs1835346,rs2000660,rs2002854,rs2027939,rs2107595,rs2246828,rs28451064,rs28601761,rs3741298,rs3829964,rs3918226,rs4835377,rs5344,rs553741,rs59877521,rs629301,rs6741243,rs6921231,rs7158073,rs7209564,rs72661887,rs72664324,rs72794188,rs7412,rs7478408,rs7608755,rs7659823,rs7774311,rs7860576,rs7995370,rs9349379,rs9515203
Coronary atherosclerosis	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	MR Egger	60	0.02	0.05	7.19E-01	0.07	rs10431974,rs1044506,rs10455872,rs10774624,rs10811665,rs10945646,rs11170821,rs113113862,rs1133220,rs11591147,rs11619038,rs11635498,rs11698996,rs117733303,rs1199337,rs12447309,rs12705390,rs12901658,rs13134800,rs137943060,rs1384705,rs1423457,rs1429125,rs1537371,rs1568488,rs16942194,rs1763943,rs1822200,rs1835346,rs2000660,rs2002854,rs2027939,rs2107595,rs2246828,rs28451064,rs28601761,rs3741298,rs3829964,rs3918226,rs4835377,rs5344,rs553741,rs59877521,rs629301,rs6741243,rs6921231,rs7158073,rs7209564,rs72661887,rs72664324,rs72794188,rs7412,rs7478408,rs7608755,rs7659823,rs7774311,rs7860576,rs7995370,rs9349379,rs9515203
Coronary atherosclerosis	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	Inverse variance weighted (fixed effects)	60	-0.07	0.01	4.64E-10	0.07	rs10431974,rs1044506,rs10455872,rs10774624,rs10811665,rs10945646,rs11170821,rs113113862,rs1133220,rs11591147,rs11619038,rs11635498,rs11698996,rs117733303,rs1199337,rs12447309,rs12705390,rs12901658,rs13134800,rs137943060,rs1384705,rs1423457,rs1429125,rs1537371,rs1568488,rs16942194,rs1763943,rs1822200,rs1835346,rs2000660,rs2002854,rs2027939,rs2107595,rs2246828,rs28451064,rs28601761,rs3741298,rs3829964,rs3918226,rs4835377,rs5344,rs553741,rs59877521,rs629301,rs6741243,rs6921231,rs7158073,rs7209564,rs72661887,rs72664324,rs72794188,rs7412,rs7478408,rs7608755,rs7659823,rs7774311,rs7860576,rs7995370,rs9349379,rs9515203
Coronary atherosclerosis	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	Inverse variance weighted (multiplicative random effects)	60	-0.07	0.02	5.09E-03	0.07	rs10431974,rs1044506,rs10455872,rs10774624,rs10811665,rs10945646,rs11170821,rs113113862,rs1133220,rs11591147,rs11619038,rs11635498,rs11698996,rs117733303,rs1199337,rs12447309,rs12705390,rs12901658,rs13134800,rs137943060,rs1384705,rs1423457,rs1429125,rs1537371,rs1568488,rs16942194,rs1763943,rs1822200,rs1835346,rs2000660,rs2002854,rs2027939,rs2107595,rs2246828,rs28451064,rs28601761,rs3741298,rs3829964,rs3918226,rs4835377,rs5344,rs553741,rs59877521,rs629301,rs6741243,rs6921231,rs7158073,rs7209564,rs72661887,rs72664324,rs72794188,rs7412,rs7478408,rs7608755,rs7659823,rs7774311,rs7860576,rs7995370,rs9349379,rs9515203
Coronary atherosclerosis	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	Weighted mode	60	0.00	0.02	8.97E-01	0.07	rs10431974,rs1044506,rs10455872,rs10774624,rs10811665,rs10945646,rs11170821,rs113113862,rs1133220,rs11591147,rs11619038,rs11635498,rs11698996,rs117733303,rs1199337,rs12447309,rs12705390,rs12901658,rs13134800,rs137943060,rs1384705,rs1423457,rs1429125,rs1537371,rs1568488,rs16942194,rs1763943,rs1822200,rs1835346,rs2000660,rs2002854,rs2027939,rs2107595,rs2246828,rs28451064,rs28601761,rs3741298,rs3829964,rs3918226,rs4835377,rs5344,rs553741,rs59877521,rs629301,rs6741243,rs6921231,rs7158073,rs7209564,rs72661887,rs72664324,rs72794188,rs7412,rs7478408,rs7608755,rs7659823,rs7774311,rs7860576,rs7995370,rs9349379,rs9515203
Coronary atherosclerosis	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	Weighted median	60	-0.03	0.02	1.46E-01	0.07	rs10431974,rs1044506,rs10455872,rs10774624,rs10811665,rs10945646,rs11170821,rs113113862,rs1133220,rs11591147,rs11619038,rs11635498,rs11698996,rs117733303,rs1199337,rs12447309,rs12705390,rs12901658,rs13134800,rs137943060,rs1384705,rs1423457,rs1429125,rs1537371,rs1568488,rs16942194,rs1763943,rs1822200,rs1835346,rs2000660,rs2002854,rs2027939,rs2107595,rs2246828,rs28451064,rs28601761,rs3741298,rs3829964,rs3918226,rs4835377,rs5344,rs553741,rs59877521,rs629301,rs6741243,rs6921231,rs7158073,rs7209564,rs72661887,rs72664324,rs72794188,rs7412,rs7478408,rs7608755,rs7659823,rs7774311,rs7860576,rs7995370,rs9349379,rs9515203
Coronary atherosclerosis	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	DIVW	60	-0.07	0.01	2.93E-10	0.07	rs10431974,rs1044506,rs10455872,rs10774624,rs10811665,rs10945646,rs11170821,rs113113862,rs1133220,rs11591147,rs11619038,rs11635498,rs11698996,rs117733303,rs1199337,rs12447309,rs12705390,rs12901658,rs13134800,rs137943060,rs1384705,rs1423457,rs1429125,rs1537371,rs1568488,rs16942194,rs1763943,rs1822200,rs1835346,rs2000660,rs2002854,rs2027939,rs2107595,rs2246828,rs28451064,rs28601761,rs3741298,rs3829964,rs3918226,rs4835377,rs5344,rs553741,rs59877521,rs629301,rs6741243,rs6921231,rs7158073,rs7209564,rs72661887,rs72664324,rs72794188,rs7412,rs7478408,rs7608755,rs7659823,rs7774311,rs7860576,rs7995370,rs9349379,rs9515203
Coronary atherosclerosis	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	GRAPPLE	60	-0.05	0.02	3.85E-02	0.07	rs10431974,rs1044506,rs10455872,rs10774624,rs10811665,rs10945646,rs11170821,rs113113862,rs1133220,rs11591147,rs11619038,rs11635498,rs11698996,rs117733303,rs1199337,rs12447309,rs12705390,rs12901658,rs13134800,rs137943060,rs1384705,rs1423457,rs1429125,rs1537371,rs1568488,rs16942194,rs1763943,rs1822200,rs1835346,rs2000660,rs2002854,rs2027939,rs2107595,rs2246828,rs28451064,rs28601761,rs3741298,rs3829964,rs3918226,rs4835377,rs5344,rs553741,rs59877521,rs629301,rs6741243,rs6921231,rs7158073,rs7209564,rs72661887,rs72664324,rs72794188,rs7412,rs7478408,rs7608755,rs7659823,rs7774311,rs7860576,rs7995370,rs9349379,rs9515203
Coronary atherosclerosis	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	mr_raps	60	-0.05	0.01	1.14E-06	0.07	rs10431974,rs1044506,rs10455872,rs10774624,rs10811665,rs10945646,rs11170821,rs113113862,rs1133220,rs11591147,rs11619038,rs11635498,rs11698996,rs117733303,rs1199337,rs12447309,rs12705390,rs12901658,rs13134800,rs137943060,rs1384705,rs1423457,rs1429125,rs1537371,rs1568488,rs16942194,rs1763943,rs1822200,rs1835346,rs2000660,rs2002854,rs2027939,rs2107595,rs2246828,rs28451064,rs28601761,rs3741298,rs3829964,rs3918226,rs4835377,rs5344,rs553741,rs59877521,rs629301,rs6741243,rs6921231,rs7158073,rs7209564,rs72661887,rs72664324,rs72794188,rs7412,rs7478408,rs7608755,rs7659823,rs7774311,rs7860576,rs7995370,rs9349379,rs9515203
Coronary atherosclerosis	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	MR Egger	60	0.02	0.05	7.16E-01	0.05	rs10431974,rs1044506,rs10455872,rs10774624,rs10811665,rs10945646,rs11170821,rs113113862,rs1133220,rs11591147,rs11619038,rs11635498,rs11698996,rs117733303,rs1199337,rs12447309,rs12705390,rs12901658,rs13134800,rs137943060,rs1384705,rs1423457,rs1429125,rs1537371,rs1568488,rs16942194,rs1763943,rs1822200,rs1835346,rs2000660,rs2002854,rs2027939,rs2107595,rs2246828,rs28451064,rs28601761,rs3741298,rs3829964,rs3918226,rs4835377,rs5344,rs553741,rs59877521,rs629301,rs6741243,rs6921231,rs7158073,rs7209564,rs72661887,rs72664324,rs72794188,rs7412,rs7478408,rs7608755,rs7659823,rs7774311,rs7860576,rs7995370,rs9349379,rs9515203
Coronary atherosclerosis	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	Inverse variance weighted (fixed effects)	60	-0.07	0.01	2.76E-11	0.05	rs10431974,rs1044506,rs10455872,rs10774624,rs10811665,rs10945646,rs11170821,rs113113862,rs1133220,rs11591147,rs11619038,rs11635498,rs11698996,rs117733303,rs1199337,rs12447309,rs12705390,rs12901658,rs13134800,rs137943060,rs1384705,rs1423457,rs1429125,rs1537371,rs1568488,rs16942194,rs1763943,rs1822200,rs1835346,rs2000660,rs2002854,rs2027939,rs2107595,rs2246828,rs28451064,rs28601761,rs3741298,rs3829964,rs3918226,rs4835377,rs5344,rs553741,rs59877521,rs629301,rs6741243,rs6921231,rs7158073,rs7209564,rs72661887,rs72664324,rs72794188,rs7412,rs7478408,rs7608755,rs7659823,rs7774311,rs7860576,rs7995370,rs9349379,rs9515203
Coronary atherosclerosis	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	Inverse variance weighted (multiplicative random effects)	60	-0.07	0.02	2.51E-03	0.05	rs10431974,rs1044506,rs10455872,rs10774624,rs10811665,rs10945646,rs11170821,rs113113862,rs1133220,rs11591147,rs11619038,rs11635498,rs11698996,rs117733303,rs1199337,rs12447309,rs12705390,rs12901658,rs13134800,rs137943060,rs1384705,rs1423457,rs1429125,rs1537371,rs1568488,rs16942194,rs1763943,rs1822200,rs1835346,rs2000660,rs2002854,rs2027939,rs2107595,rs2246828,rs28451064,rs28601761,rs3741298,rs3829964,rs3918226,rs4835377,rs5344,rs553741,rs59877521,rs629301,rs6741243,rs6921231,rs7158073,rs7209564,rs72661887,rs72664324,rs72794188,rs7412,rs7478408,rs7608755,rs7659823,rs7774311,rs7860576,rs7995370,rs9349379,rs9515203
Coronary atherosclerosis	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	Weighted mode	60	-0.01	0.02	7.17E-01	0.05	rs10431974,rs1044506,rs10455872,rs10774624,rs10811665,rs10945646,rs11170821,rs113113862,rs1133220,rs11591147,rs11619038,rs11635498,rs11698996,rs117733303,rs1199337,rs12447309,rs12705390,rs12901658,rs13134800,rs137943060,rs1384705,rs1423457,rs1429125,rs1537371,rs1568488,rs16942194,rs1763943,rs1822200,rs1835346,rs2000660,rs2002854,rs2027939,rs2107595,rs2246828,rs28451064,rs28601761,rs3741298,rs3829964,rs3918226,rs4835377,rs5344,rs553741,rs59877521,rs629301,rs6741243,rs6921231,rs7158073,rs7209564,rs72661887,rs72664324,rs72794188,rs7412,rs7478408,rs7608755,rs7659823,rs7774311,rs7860576,rs7995370,rs9349379,rs9515203
Coronary atherosclerosis	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	Weighted median	60	-0.03	0.02	1.68E-01	0.05	rs10431974,rs1044506,rs10455872,rs10774624,rs10811665,rs10945646,rs11170821,rs113113862,rs1133220,rs11591147,rs11619038,rs11635498,rs11698996,rs117733303,rs1199337,rs12447309,rs12705390,rs12901658,rs13134800,rs137943060,rs1384705,rs1423457,rs1429125,rs1537371,rs1568488,rs16942194,rs1763943,rs1822200,rs1835346,rs2000660,rs2002854,rs2027939,rs2107595,rs2246828,rs28451064,rs28601761,rs3741298,rs3829964,rs3918226,rs4835377,rs5344,rs553741,rs59877521,rs629301,rs6741243,rs6921231,rs7158073,rs7209564,rs72661887,rs72664324,rs72794188,rs7412,rs7478408,rs7608755,rs7659823,rs7774311,rs7860576,rs7995370,rs9349379,rs9515203
Coronary atherosclerosis	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	DIVW	60	-0.07	0.01	1.87E-11	0.05	rs10431974,rs1044506,rs10455872,rs10774624,rs10811665,rs10945646,rs11170821,rs113113862,rs1133220,rs11591147,rs11619038,rs11635498,rs11698996,rs117733303,rs1199337,rs12447309,rs12705390,rs12901658,rs13134800,rs137943060,rs1384705,rs1423457,rs1429125,rs1537371,rs1568488,rs16942194,rs1763943,rs1822200,rs1835346,rs2000660,rs2002854,rs2027939,rs2107595,rs2246828,rs28451064,rs28601761,rs3741298,rs3829964,rs3918226,rs4835377,rs5344,rs553741,rs59877521,rs629301,rs6741243,rs6921231,rs7158073,rs7209564,rs72661887,rs72664324,rs72794188,rs7412,rs7478408,rs7608755,rs7659823,rs7774311,rs7860576,rs7995370,rs9349379,rs9515203
Coronary atherosclerosis	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	GRAPPLE	60	-0.05	0.02	1.83E-02	0.05	rs10431974,rs1044506,rs10455872,rs10774624,rs10811665,rs10945646,rs11170821,rs113113862,rs1133220,rs11591147,rs11619038,rs11635498,rs11698996,rs117733303,rs1199337,rs12447309,rs12705390,rs12901658,rs13134800,rs137943060,rs1384705,rs1423457,rs1429125,rs1537371,rs1568488,rs16942194,rs1763943,rs1822200,rs1835346,rs2000660,rs2002854,rs2027939,rs2107595,rs2246828,rs28451064,rs28601761,rs3741298,rs3829964,rs3918226,rs4835377,rs5344,rs553741,rs59877521,rs629301,rs6741243,rs6921231,rs7158073,rs7209564,rs72661887,rs72664324,rs72794188,rs7412,rs7478408,rs7608755,rs7659823,rs7774311,rs7860576,rs7995370,rs9349379,rs9515203
Coronary atherosclerosis	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	mr_raps	60	-0.06	0.01	1.86E-07	0.05	rs10431974,rs1044506,rs10455872,rs10774624,rs10811665,rs10945646,rs11170821,rs113113862,rs1133220,rs11591147,rs11619038,rs11635498,rs11698996,rs117733303,rs1199337,rs12447309,rs12705390,rs12901658,rs13134800,rs137943060,rs1384705,rs1423457,rs1429125,rs1537371,rs1568488,rs16942194,rs1763943,rs1822200,rs1835346,rs2000660,rs2002854,rs2027939,rs2107595,rs2246828,rs28451064,rs28601761,rs3741298,rs3829964,rs3918226,rs4835377,rs5344,rs553741,rs59877521,rs629301,rs6741243,rs6921231,rs7158073,rs7209564,rs72661887,rs72664324,rs72794188,rs7412,rs7478408,rs7608755,rs7659823,rs7774311,rs7860576,rs7995370,rs9349379,rs9515203
Hard cardiovascular diseases	Cardiometabolic endpoints	descending aorta maximum area	MR Egger	31	0.04	0.10	6.61E-01	0.15	rs10402946,rs11238794,rs112732186,rs113113862,rs11591147,rs11632102,rs118039278,rs1208256,rs12705390,rs13260,rs137943060,rs147750986,rs1537371,rs17163301,rs2027939,rs2107595,rs28451064,rs35166119,rs3918226,rs4835377,rs494198,rs629301,rs653178,rs6855875,rs6871143,rs6904438,rs7412,rs896655,rs9295128,rs9349379,rs9515203
Hard cardiovascular diseases	Cardiometabolic endpoints	descending aorta maximum area	Inverse variance weighted (fixed effects)	31	-0.08	0.02	2.73E-06	0.15	rs10402946,rs11238794,rs112732186,rs113113862,rs11591147,rs11632102,rs118039278,rs1208256,rs12705390,rs13260,rs137943060,rs147750986,rs1537371,rs17163301,rs2027939,rs2107595,rs28451064,rs35166119,rs3918226,rs4835377,rs494198,rs629301,rs653178,rs6855875,rs6871143,rs6904438,rs7412,rs896655,rs9295128,rs9349379,rs9515203
Hard cardiovascular diseases	Cardiometabolic endpoints	descending aorta maximum area	Inverse variance weighted (multiplicative random effects)	31	-0.08	0.04	5.45E-02	0.15	rs10402946,rs11238794,rs112732186,rs113113862,rs11591147,rs11632102,rs118039278,rs1208256,rs12705390,rs13260,rs137943060,rs147750986,rs1537371,rs17163301,rs2027939,rs2107595,rs28451064,rs35166119,rs3918226,rs4835377,rs494198,rs629301,rs653178,rs6855875,rs6871143,rs6904438,rs7412,rs896655,rs9295128,rs9349379,rs9515203
Hard cardiovascular diseases	Cardiometabolic endpoints	descending aorta maximum area	Weighted mode	31	-0.01	0.03	7.14E-01	0.15	rs10402946,rs11238794,rs112732186,rs113113862,rs11591147,rs11632102,rs118039278,rs1208256,rs12705390,rs13260,rs137943060,rs147750986,rs1537371,rs17163301,rs2027939,rs2107595,rs28451064,rs35166119,rs3918226,rs4835377,rs494198,rs629301,rs653178,rs6855875,rs6871143,rs6904438,rs7412,rs896655,rs9295128,rs9349379,rs9515203
Hard cardiovascular diseases	Cardiometabolic endpoints	descending aorta maximum area	Weighted median	31	-0.04	0.03	1.35E-01	0.15	rs10402946,rs11238794,rs112732186,rs113113862,rs11591147,rs11632102,rs118039278,rs1208256,rs12705390,rs13260,rs137943060,rs147750986,rs1537371,rs17163301,rs2027939,rs2107595,rs28451064,rs35166119,rs3918226,rs4835377,rs494198,rs629301,rs653178,rs6855875,rs6871143,rs6904438,rs7412,rs896655,rs9295128,rs9349379,rs9515203
Hard cardiovascular diseases	Cardiometabolic endpoints	descending aorta maximum area	DIVW	31	-0.09	0.02	1.60E-06	0.15	rs10402946,rs11238794,rs112732186,rs113113862,rs11591147,rs11632102,rs118039278,rs1208256,rs12705390,rs13260,rs137943060,rs147750986,rs1537371,rs17163301,rs2027939,rs2107595,rs28451064,rs35166119,rs3918226,rs4835377,rs494198,rs629301,rs653178,rs6855875,rs6871143,rs6904438,rs7412,rs896655,rs9295128,rs9349379,rs9515203
Hard cardiovascular diseases	Cardiometabolic endpoints	descending aorta maximum area	GRAPPLE	31	-0.06	0.04	1.28E-01	0.15	rs10402946,rs11238794,rs112732186,rs113113862,rs11591147,rs11632102,rs118039278,rs1208256,rs12705390,rs13260,rs137943060,rs147750986,rs1537371,rs17163301,rs2027939,rs2107595,rs28451064,rs35166119,rs3918226,rs4835377,rs494198,rs629301,rs653178,rs6855875,rs6871143,rs6904438,rs7412,rs896655,rs9295128,rs9349379,rs9515203
Hard cardiovascular diseases	Cardiometabolic endpoints	descending aorta maximum area	mr_raps	31	-0.06	0.02	2.31E-03	0.15	rs10402946,rs11238794,rs112732186,rs113113862,rs11591147,rs11632102,rs118039278,rs1208256,rs12705390,rs13260,rs137943060,rs147750986,rs1537371,rs17163301,rs2027939,rs2107595,rs28451064,rs35166119,rs3918226,rs4835377,rs494198,rs629301,rs653178,rs6855875,rs6871143,rs6904438,rs7412,rs896655,rs9295128,rs9349379,rs9515203
Hard cardiovascular diseases	Cardiometabolic endpoints	descending aorta minimum area	MR Egger	31	0.04	0.10	6.61E-01	0.14	rs10402946,rs11238794,rs112732186,rs113113862,rs11591147,rs11632102,rs118039278,rs1208256,rs12705390,rs13260,rs137943060,rs147750986,rs1537371,rs17163301,rs2027939,rs2107595,rs28451064,rs35166119,rs3918226,rs4835377,rs494198,rs629301,rs653178,rs6855875,rs6871143,rs6904438,rs7412,rs896655,rs9295128,rs9349379,rs9515203
Hard cardiovascular diseases	Cardiometabolic endpoints	descending aorta minimum area	Inverse variance weighted (fixed effects)	31	-0.09	0.02	8.29E-07	0.14	rs10402946,rs11238794,rs112732186,rs113113862,rs11591147,rs11632102,rs118039278,rs1208256,rs12705390,rs13260,rs137943060,rs147750986,rs1537371,rs17163301,rs2027939,rs2107595,rs28451064,rs35166119,rs3918226,rs4835377,rs494198,rs629301,rs653178,rs6855875,rs6871143,rs6904438,rs7412,rs896655,rs9295128,rs9349379,rs9515203
Hard cardiovascular diseases	Cardiometabolic endpoints	descending aorta minimum area	Inverse variance weighted (multiplicative random effects)	31	-0.09	0.04	4.52E-02	0.14	rs10402946,rs11238794,rs112732186,rs113113862,rs11591147,rs11632102,rs118039278,rs1208256,rs12705390,rs13260,rs137943060,rs147750986,rs1537371,rs17163301,rs2027939,rs2107595,rs28451064,rs35166119,rs3918226,rs4835377,rs494198,rs629301,rs653178,rs6855875,rs6871143,rs6904438,rs7412,rs896655,rs9295128,rs9349379,rs9515203
Hard cardiovascular diseases	Cardiometabolic endpoints	descending aorta minimum area	Weighted mode	31	-0.01	0.03	6.37E-01	0.14	rs10402946,rs11238794,rs112732186,rs113113862,rs11591147,rs11632102,rs118039278,rs1208256,rs12705390,rs13260,rs137943060,rs147750986,rs1537371,rs17163301,rs2027939,rs2107595,rs28451064,rs35166119,rs3918226,rs4835377,rs494198,rs629301,rs653178,rs6855875,rs6871143,rs6904438,rs7412,rs896655,rs9295128,rs9349379,rs9515203
Hard cardiovascular diseases	Cardiometabolic endpoints	descending aorta minimum area	Weighted median	31	-0.03	0.03	2.95E-01	0.14	rs10402946,rs11238794,rs112732186,rs113113862,rs11591147,rs11632102,rs118039278,rs1208256,rs12705390,rs13260,rs137943060,rs147750986,rs1537371,rs17163301,rs2027939,rs2107595,rs28451064,rs35166119,rs3918226,rs4835377,rs494198,rs629301,rs653178,rs6855875,rs6871143,rs6904438,rs7412,rs896655,rs9295128,rs9349379,rs9515203
Hard cardiovascular diseases	Cardiometabolic endpoints	descending aorta minimum area	DIVW	31	-0.09	0.02	5.04E-07	0.14	rs10402946,rs11238794,rs112732186,rs113113862,rs11591147,rs11632102,rs118039278,rs1208256,rs12705390,rs13260,rs137943060,rs147750986,rs1537371,rs17163301,rs2027939,rs2107595,rs28451064,rs35166119,rs3918226,rs4835377,rs494198,rs629301,rs653178,rs6855875,rs6871143,rs6904438,rs7412,rs896655,rs9295128,rs9349379,rs9515203
Hard cardiovascular diseases	Cardiometabolic endpoints	descending aorta minimum area	GRAPPLE	31	-0.06	0.04	9.83E-02	0.14	rs10402946,rs11238794,rs112732186,rs113113862,rs11591147,rs11632102,rs118039278,rs1208256,rs12705390,rs13260,rs137943060,rs147750986,rs1537371,rs17163301,rs2027939,rs2107595,rs28451064,rs35166119,rs3918226,rs4835377,rs494198,rs629301,rs653178,rs6855875,rs6871143,rs6904438,rs7412,rs896655,rs9295128,rs9349379,rs9515203
Hard cardiovascular diseases	Cardiometabolic endpoints	descending aorta minimum area	mr_raps	31	-0.06	0.02	7.76E-04	0.14	rs10402946,rs11238794,rs112732186,rs113113862,rs11591147,rs11632102,rs118039278,rs1208256,rs12705390,rs13260,rs137943060,rs147750986,rs1537371,rs17163301,rs2027939,rs2107595,rs28451064,rs35166119,rs3918226,rs4835377,rs494198,rs629301,rs653178,rs6855875,rs6871143,rs6904438,rs7412,rs896655,rs9295128,rs9349379,rs9515203
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	global myocardial-wall thickness at end-diastole	MR Egger	18	0.16	0.22	4.72E-01	0.89	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	global myocardial-wall thickness at end-diastole	Inverse variance weighted (fixed effects)	18	0.19	0.03	2.17E-08	0.89	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	global myocardial-wall thickness at end-diastole	Inverse variance weighted (multiplicative random effects)	18	0.19	0.05	7.77E-05	0.89	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	global myocardial-wall thickness at end-diastole	Weighted mode	18	0.11	0.07	1.54E-01	0.89	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	global myocardial-wall thickness at end-diastole	Weighted median	18	0.14	0.05	9.54E-03	0.89	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	global myocardial-wall thickness at end-diastole	DIVW	18	0.20	0.04	2.14E-08	0.89	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	global myocardial-wall thickness at end-diastole	GRAPPLE	18	0.19	0.05	2.78E-04	0.89	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	global myocardial-wall thickness at end-diastole	mr_raps	18	0.18	0.04	1.49E-06	0.89	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	left ventricular myocardial mass	MR Egger	18	-0.07	0.19	7.04E-01	0.26	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	left ventricular myocardial mass	Inverse variance weighted (fixed effects)	18	0.14	0.03	1.55E-06	0.26	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	left ventricular myocardial mass	Inverse variance weighted (multiplicative random effects)	18	0.14	0.04	1.27E-03	0.26	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	left ventricular myocardial mass	Weighted mode	18	0.04	0.08	6.30E-01	0.26	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	left ventricular myocardial mass	Weighted median	18	0.06	0.05	1.71E-01	0.26	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	left ventricular myocardial mass	DIVW	18	0.14	0.03	1.13E-06	0.26	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	left ventricular myocardial mass	GRAPPLE	18	0.15	0.05	2.72E-03	0.26	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	left ventricular myocardial mass	mr_raps	18	0.14	0.03	3.82E-06	0.26	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 1	MR Egger	18	-0.14	0.26	5.97E-01	0.18	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 1	Inverse variance weighted (fixed effects)	18	0.22	0.04	4.05E-07	0.18	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 1	Inverse variance weighted (multiplicative random effects)	18	0.22	0.06	5.23E-04	0.18	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 1	Weighted mode	18	0.32	0.14	3.66E-02	0.18	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 1	Weighted median	18	0.21	0.07	1.51E-03	0.18	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 1	DIVW	18	0.22	0.04	3.21E-07	0.18	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 1	GRAPPLE	18	0.22	0.07	8.75E-04	0.18	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 1	mr_raps	18	0.25	0.05	6.51E-08	0.18	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 11	MR Egger	18	-0.08	0.22	7.19E-01	0.26	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 11	Inverse variance weighted (fixed effects)	18	0.17	0.04	2.46E-06	0.26	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 11	Inverse variance weighted (multiplicative random effects)	18	0.17	0.05	7.56E-04	0.26	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 11	Weighted mode	18	0.07	0.09	4.77E-01	0.26	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 11	Weighted median	18	0.14	0.06	2.04E-02	0.26	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 11	DIVW	18	0.18	0.04	1.74E-06	0.26	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 11	GRAPPLE	18	0.17	0.06	2.79E-03	0.26	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 11	mr_raps	18	0.18	0.04	4.93E-06	0.26	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 12	MR Egger	18	0.19	0.24	4.26E-01	0.96	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 12	Inverse variance weighted (fixed effects)	18	0.21	0.04	1.80E-08	0.96	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 12	Inverse variance weighted (multiplicative random effects)	18	0.21	0.05	8.83E-05	0.96	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 12	Weighted mode	18	0.10	0.09	2.89E-01	0.96	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 12	Weighted median	18	0.15	0.06	8.18E-03	0.96	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 12	DIVW	18	0.21	0.04	1.80E-08	0.96	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 12	GRAPPLE	18	0.21	0.06	1.68E-04	0.96	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 12	mr_raps	18	0.20	0.04	4.05E-07	0.96	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 7	MR Egger	18	0.35	0.23	1.42E-01	0.52	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 7	Inverse variance weighted (fixed effects)	18	0.20	0.04	4.40E-08	0.52	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 7	Inverse variance weighted (multiplicative random effects)	18	0.20	0.05	6.43E-05	0.52	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 7	Weighted mode	18	0.12	0.09	2.00E-01	0.52	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 7	Weighted median	18	0.15	0.06	7.94E-03	0.52	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 7	DIVW	18	0.21	0.04	4.09E-08	0.52	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 7	GRAPPLE	18	0.21	0.05	9.20E-05	0.52	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 7	mr_raps	18	0.20	0.04	6.81E-07	0.52	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 8	MR Egger	18	0.33	0.27	2.41E-01	0.57	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 8	Inverse variance weighted (fixed effects)	18	0.18	0.04	4.75E-06	0.57	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 8	Inverse variance weighted (multiplicative random effects)	18	0.18	0.06	3.50E-03	0.57	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 8	Weighted mode	18	0.16	0.10	1.45E-01	0.57	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 8	Weighted median	18	0.16	0.06	6.87E-03	0.57	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 8	DIVW	18	0.18	0.04	3.24E-06	0.57	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 8	GRAPPLE	18	0.20	0.06	2.03E-03	0.57	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 8	mr_raps	18	0.19	0.04	5.05E-06	0.57	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 9	MR Egger	18	0.12	0.26	6.52E-01	0.82	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 9	Inverse variance weighted (fixed effects)	18	0.18	0.04	8.17E-07	0.82	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 9	Inverse variance weighted (multiplicative random effects)	18	0.18	0.06	1.98E-03	0.82	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 9	Weighted mode	18	0.09	0.08	3.08E-01	0.82	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 9	Weighted median	18	0.09	0.06	1.10E-01	0.82	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 9	DIVW	18	0.18	0.04	6.18E-07	0.82	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 9	GRAPPLE	18	0.17	0.06	6.80E-03	0.82	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Cardiovascular diseases	IX Diseases of the circulatory system (I9_)	regional myocardial-wall thickness at end-diastole 9	mr_raps	18	0.16	0.04	2.66E-05	0.82	rs1106270,rs11121615,rs1121980,rs11694327,rs12509595,rs1363561,rs167479,rs2704368,rs284278,rs3019196,rs3824754,rs3918226,rs635634,rs6823438,rs73306874,rs74661587,rs7552539,rs77309872
Heart failure and antihypertensive medication	Cardiometabolic endpoints	ascending aorta distensibility	MR Egger	22	0.08	0.14	5.83E-01	0.22	rs10774624,rs11126666,rs116951734,rs11774829,rs1214759,rs12418543,rs12426399,rs13118687,rs1333042,rs16998073,rs17042171,rs17608766,rs2327429,rs3131004,rs3176323,rs3770770,rs3918226,rs4324466,rs72699046,rs73073444,rs7680240,rs880315
Heart failure and antihypertensive medication	Cardiometabolic endpoints	ascending aorta distensibility	Inverse variance weighted (fixed effects)	22	-0.09	0.02	3.72E-07	0.22	rs10774624,rs11126666,rs116951734,rs11774829,rs1214759,rs12418543,rs12426399,rs13118687,rs1333042,rs16998073,rs17042171,rs17608766,rs2327429,rs3131004,rs3176323,rs3770770,rs3918226,rs4324466,rs72699046,rs73073444,rs7680240,rs880315
Heart failure and antihypertensive medication	Cardiometabolic endpoints	ascending aorta distensibility	Inverse variance weighted (multiplicative random effects)	22	-0.09	0.03	5.74E-03	0.22	rs10774624,rs11126666,rs116951734,rs11774829,rs1214759,rs12418543,rs12426399,rs13118687,rs1333042,rs16998073,rs17042171,rs17608766,rs2327429,rs3131004,rs3176323,rs3770770,rs3918226,rs4324466,rs72699046,rs73073444,rs7680240,rs880315
Heart failure and antihypertensive medication	Cardiometabolic endpoints	ascending aorta distensibility	Weighted mode	22	-0.09	0.06	1.47E-01	0.22	rs10774624,rs11126666,rs116951734,rs11774829,rs1214759,rs12418543,rs12426399,rs13118687,rs1333042,rs16998073,rs17042171,rs17608766,rs2327429,rs3131004,rs3176323,rs3770770,rs3918226,rs4324466,rs72699046,rs73073444,rs7680240,rs880315
Heart failure and antihypertensive medication	Cardiometabolic endpoints	ascending aorta distensibility	Weighted median	22	-0.08	0.03	1.38E-02	0.22	rs10774624,rs11126666,rs116951734,rs11774829,rs1214759,rs12418543,rs12426399,rs13118687,rs1333042,rs16998073,rs17042171,rs17608766,rs2327429,rs3131004,rs3176323,rs3770770,rs3918226,rs4324466,rs72699046,rs73073444,rs7680240,rs880315
Heart failure and antihypertensive medication	Cardiometabolic endpoints	ascending aorta distensibility	DIVW	22	-0.10	0.02	2.84E-07	0.22	rs10774624,rs11126666,rs116951734,rs11774829,rs1214759,rs12418543,rs12426399,rs13118687,rs1333042,rs16998073,rs17042171,rs17608766,rs2327429,rs3131004,rs3176323,rs3770770,rs3918226,rs4324466,rs72699046,rs73073444,rs7680240,rs880315
Heart failure and antihypertensive medication	Cardiometabolic endpoints	ascending aorta distensibility	GRAPPLE	22	-0.09	0.04	1.53E-02	0.22	rs10774624,rs11126666,rs116951734,rs11774829,rs1214759,rs12418543,rs12426399,rs13118687,rs1333042,rs16998073,rs17042171,rs17608766,rs2327429,rs3131004,rs3176323,rs3770770,rs3918226,rs4324466,rs72699046,rs73073444,rs7680240,rs880315
Heart failure and antihypertensive medication	Cardiometabolic endpoints	ascending aorta distensibility	mr_raps	22	-0.10	0.02	1.26E-07	0.22	rs10774624,rs11126666,rs116951734,rs11774829,rs1214759,rs12418543,rs12426399,rs13118687,rs1333042,rs16998073,rs17042171,rs17608766,rs2327429,rs3131004,rs3176323,rs3770770,rs3918226,rs4324466,rs72699046,rs73073444,rs7680240,rs880315
Heart failure and antihypertensive medication	Cardiometabolic endpoints	left ventricular myocardial mass	MR Egger	22	-0.04	0.12	7.20E-01	0.39	rs10774624,rs11126666,rs116951734,rs11774829,rs1214759,rs12418543,rs12426399,rs13118687,rs1333042,rs16998073,rs17042171,rs17608766,rs2327429,rs3131004,rs3176323,rs3770770,rs3918226,rs4324466,rs72699046,rs73073444,rs7680240,rs880315
Heart failure and antihypertensive medication	Cardiometabolic endpoints	left ventricular myocardial mass	Inverse variance weighted (fixed effects)	22	0.06	0.01	1.44E-06	0.39	rs10774624,rs11126666,rs116951734,rs11774829,rs1214759,rs12418543,rs12426399,rs13118687,rs1333042,rs16998073,rs17042171,rs17608766,rs2327429,rs3131004,rs3176323,rs3770770,rs3918226,rs4324466,rs72699046,rs73073444,rs7680240,rs880315
Heart failure and antihypertensive medication	Cardiometabolic endpoints	left ventricular myocardial mass	Inverse variance weighted (multiplicative random effects)	22	0.06	0.03	3.63E-02	0.39	rs10774624,rs11126666,rs116951734,rs11774829,rs1214759,rs12418543,rs12426399,rs13118687,rs1333042,rs16998073,rs17042171,rs17608766,rs2327429,rs3131004,rs3176323,rs3770770,rs3918226,rs4324466,rs72699046,rs73073444,rs7680240,rs880315
Heart failure and antihypertensive medication	Cardiometabolic endpoints	left ventricular myocardial mass	Weighted mode	22	0.11	0.05	3.59E-02	0.39	rs10774624,rs11126666,rs116951734,rs11774829,rs1214759,rs12418543,rs12426399,rs13118687,rs1333042,rs16998073,rs17042171,rs17608766,rs2327429,rs3131004,rs3176323,rs3770770,rs3918226,rs4324466,rs72699046,rs73073444,rs7680240,rs880315
Heart failure and antihypertensive medication	Cardiometabolic endpoints	left ventricular myocardial mass	Weighted median	22	0.07	0.02	9.33E-04	0.39	rs10774624,rs11126666,rs116951734,rs11774829,rs1214759,rs12418543,rs12426399,rs13118687,rs1333042,rs16998073,rs17042171,rs17608766,rs2327429,rs3131004,rs3176323,rs3770770,rs3918226,rs4324466,rs72699046,rs73073444,rs7680240,rs880315
Heart failure and antihypertensive medication	Cardiometabolic endpoints	left ventricular myocardial mass	DIVW	22	0.06	0.01	1.02E-06	0.39	rs10774624,rs11126666,rs116951734,rs11774829,rs1214759,rs12418543,rs12426399,rs13118687,rs1333042,rs16998073,rs17042171,rs17608766,rs2327429,rs3131004,rs3176323,rs3770770,rs3918226,rs4324466,rs72699046,rs73073444,rs7680240,rs880315
Heart failure and antihypertensive medication	Cardiometabolic endpoints	left ventricular myocardial mass	GRAPPLE	22	0.06	0.03	4.64E-02	0.39	rs10774624,rs11126666,rs116951734,rs11774829,rs1214759,rs12418543,rs12426399,rs13118687,rs1333042,rs16998073,rs17042171,rs17608766,rs2327429,rs3131004,rs3176323,rs3770770,rs3918226,rs4324466,rs72699046,rs73073444,rs7680240,rs880315
Heart failure and antihypertensive medication	Cardiometabolic endpoints	left ventricular myocardial mass	mr_raps	22	0.10	0.01	2.44E-14	0.39	rs10774624,rs11126666,rs116951734,rs11774829,rs1214759,rs12418543,rs12426399,rs13118687,rs1333042,rs16998073,rs17042171,rs17608766,rs2327429,rs3131004,rs3176323,rs3770770,rs3918226,rs4324466,rs72699046,rs73073444,rs7680240,rs880315
Hypertension	IX Diseases of the circulatory system (I9_)	ascending aorta distensibility	MR Egger	161	-0.12	0.05	3.36E-02	0.91	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	ascending aorta distensibility	Inverse variance weighted (fixed effects)	161	-0.11	0.01	1.78E-17	0.91	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	ascending aorta distensibility	Inverse variance weighted (multiplicative random effects)	161	-0.11	0.02	6.09E-12	0.91	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	ascending aorta distensibility	Weighted mode	161	-0.17	0.05	1.69E-03	0.91	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	ascending aorta distensibility	Weighted median	161	-0.13	0.02	2.99E-11	0.91	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	ascending aorta distensibility	DIVW	161	-0.11	0.01	0.00E+00	0.91	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	ascending aorta distensibility	GRAPPLE	161	-0.11	0.02	9.42E-11	0.91	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	ascending aorta distensibility	mr_raps	161	-0.12	0.01	0.00E+00	0.91	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	ascending aorta maximum area	MR Egger	161	0.14	0.07	3.22E-02	0.65	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	ascending aorta maximum area	Inverse variance weighted (fixed effects)	161	0.11	0.01	1.81E-18	0.65	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	ascending aorta maximum area	Inverse variance weighted (multiplicative random effects)	161	0.11	0.02	6.29E-09	0.65	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	ascending aorta maximum area	Weighted mode	161	0.15	0.08	8.32E-02	0.65	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	ascending aorta maximum area	Weighted median	161	0.10	0.02	3.52E-06	0.65	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	ascending aorta maximum area	DIVW	161	0.12	0.01	0.00E+00	0.65	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	ascending aorta maximum area	GRAPPLE	161	0.10	0.02	1.49E-07	0.65	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	ascending aorta maximum area	mr_raps	161	0.11	0.01	6.66E-16	0.65	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	MR Egger	161	0.16	0.07	1.77E-02	0.53	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	Inverse variance weighted (fixed effects)	161	0.12	0.01	1.27E-20	0.53	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	Inverse variance weighted (multiplicative random effects)	161	0.12	0.02	1.35E-09	0.53	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	Weighted mode	161	0.19	0.09	3.54E-02	0.53	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	Weighted median	161	0.11	0.02	1.23E-07	0.53	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	DIVW	161	0.12	0.01	0.00E+00	0.53	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	GRAPPLE	161	0.11	0.02	4.41E-08	0.53	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	ascending aorta minimum area	mr_raps	161	0.12	0.01	0.00E+00	0.53	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	descending aorta distensibility	MR Egger	161	-0.13	0.06	2.50E-02	0.58	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	descending aorta distensibility	Inverse variance weighted (fixed effects)	161	-0.10	0.01	5.33E-13	0.58	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	descending aorta distensibility	Inverse variance weighted (multiplicative random effects)	161	-0.10	0.02	5.09E-09	0.58	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	descending aorta distensibility	Weighted mode	161	-0.12	0.05	3.11E-02	0.58	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	descending aorta distensibility	Weighted median	161	-0.10	0.02	7.11E-06	0.58	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	descending aorta distensibility	DIVW	161	-0.10	0.01	3.25E-13	0.58	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	descending aorta distensibility	GRAPPLE	161	-0.09	0.02	9.40E-07	0.58	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	descending aorta distensibility	mr_raps	161	-0.09	0.01	1.14E-10	0.58	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	MR Egger	161	0.04	0.06	4.83E-01	0.68	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	Inverse variance weighted (fixed effects)	161	0.07	0.01	4.30E-09	0.68	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	Inverse variance weighted (multiplicative random effects)	161	0.07	0.02	2.03E-04	0.68	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	Weighted mode	161	0.04	0.07	6.12E-01	0.68	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	Weighted median	161	0.06	0.02	1.93E-03	0.68	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	DIVW	161	0.07	0.01	2.35E-09	0.68	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	GRAPPLE	161	0.05	0.02	4.46E-03	0.68	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	descending aorta maximum area	mr_raps	161	0.07	0.01	1.13E-09	0.68	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	MR Egger	161	0.04	0.06	5.13E-01	0.67	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	Inverse variance weighted (fixed effects)	161	0.06	0.01	6.45E-09	0.67	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	Inverse variance weighted (multiplicative random effects)	161	0.06	0.02	3.42E-04	0.67	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	Weighted mode	161	0.06	0.06	3.36E-01	0.67	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	Weighted median	161	0.07	0.02	1.19E-04	0.67	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	DIVW	161	0.07	0.01	3.51E-09	0.67	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	GRAPPLE	161	0.05	0.02	4.53E-03	0.67	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	descending aorta minimum area	mr_raps	161	0.07	0.01	1.95E-10	0.67	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	global myocardial-wall thickness at end-diastole	MR Egger	161	0.20	0.05	2.20E-05	0.29	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	global myocardial-wall thickness at end-diastole	Inverse variance weighted (fixed effects)	161	0.16	0.01	2.18E-54	0.29	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	global myocardial-wall thickness at end-diastole	Inverse variance weighted (multiplicative random effects)	161	0.16	0.01	1.80E-29	0.29	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	global myocardial-wall thickness at end-diastole	Weighted mode	161	0.19	0.06	1.36E-03	0.29	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	global myocardial-wall thickness at end-diastole	Weighted median	161	0.17	0.02	5.14E-23	0.29	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	global myocardial-wall thickness at end-diastole	DIVW	161	0.16	0.01	0.00E+00	0.29	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	global myocardial-wall thickness at end-diastole	GRAPPLE	161	0.16	0.01	3.26E-28	0.29	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	global myocardial-wall thickness at end-diastole	mr_raps	161	0.16	0.01	0.00E+00	0.29	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	global radial strain	MR Egger	161	0.17	0.05	1.26E-03	0.10	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1504262,rs1515114,rs1517287,rs1555959,rs1567316,rs1571217,rs167479,rs16853076,rs16998073,rs17080102,rs187104477,rs1879053,rs1888693,rs1980235,rs2005873,rs2061540,rs2062316,rs2230738,rs2246298,rs2286526,rs2304616,rs2392929,rs2395166,rs2643826,rs2699813,rs2704368,rs27527,rs2782981,rs289033,rs2898883,rs3088186,rs34275350,rs35198836,rs35395156,rs35429,rs35783704,rs35784342,rs3731503,rs3735533,rs3817135,rs3821843,rs3918226,rs4320727,rs4371736,rs4666813,rs4685218,rs4685222,rs4759318,rs4812042,rs535024,rs55640925,rs55673113,rs55761308,rs557675,rs55893963,rs56197924,rs57541197,rs5762879,rs5772,rs5994376,rs60069508,rs604723,rs60595656,rs60776549,rs61733954,rs61877008,rs6227,rs62394299,rs62426324,rs629042,rs6588636,rs67286798,rs6818149,rs6860901,rs706797,rs7123454,rs7125196,rs7129204,rs7134440,rs7139122,rs71636788,rs7246865,rs72685660,rs72779268,rs72794235,rs72831851,rs72877309,rs7302030,rs73043547,rs73073481,rs73073676,rs7341791,rs74403214,rs74661587,rs75596153,rs76313422,rs7742789,rs77434154,rs77693762,rs7799408,rs78412528,rs7893754,rs7898224,rs79284865,rs79780963,rs836180,rs858526,rs880315,rs9352691,rs9508490,rs9679855,rs9848210,rs9899012,rs9940128
Hypertension	IX Diseases of the circulatory system (I9_)	global radial strain	Inverse variance weighted (fixed effects)	161	0.09	0.01	1.73E-11	0.10	rs10033071,rs10059884,rs1008410,rs10170836,rs10206833,rs10217559,rs1023761,rs10766315,rs10776752,rs10786736,rs111283598,rs11187789,rs113197165,rs1136165,rs114463908,rs11645355,rs11672460,rs11712101,rs117185762,rs11763813,rs11773825,rs11867639,rs11874,rs11892,rs12187571,rs12258967,rs12481717,rs12503104,rs12599980,rs1275984,rs12828438,rs12952507,rs13112725,rs13118915,rs1314921,rs1317181,rs13300881,rs13306561,rs138808993,rs141280168,rs141878040,rs144413645,rs1446468,rs146292009,rs146781867,rs149150643,rs149504064,rs1

Heart & clinical endpoints

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Overview of Heart MR results

Clinical endpoints -> Heart

Heart -> Clinical endpoints

Heart MR results

Heart to clinical outcomes

Clinical outcomes to Heart